Leukemia Research
Volume 29, Issue 2 , Pages 229-231 , February 2005

A novel p27 gene mutation in a case of unclassified myeloproliferative disorder

  • V. Pappa

      Affiliations

    • Second Department of Internal Medicine Propaedeutic, Attikon University General Hospital, Rimini 1, Chaidari, Athens, Greece
    • Corresponding Author InformationCorresponding author. Tel.: +30 210 5831000x1687/2306; fax: +30 210 5326454.
    • ,
  • S. Papageorgiou

      Affiliations

    • Second Department of Internal Medicine Propaedeutic, Attikon University General Hospital, Rimini 1, Chaidari, Athens, Greece
    • ,
  • E. Papageorgiou

      Affiliations

    • Second Department of Internal Medicine Propaedeutic, Attikon University General Hospital, Rimini 1, Chaidari, Athens, Greece
    • ,
  • A. Panani

      Affiliations

    • Second Department of Internal Medicine Propaedeutic, Attikon University General Hospital, Rimini 1, Chaidari, Athens, Greece
    • ,
  • E. Boutou

      Affiliations

    • Department of Biology, Section of Biochemistry and Molecular Biology, School of Sciences, Athens University, Rimini 1, Chaidari, Athens, Greece
    • ,
  • P. Tsirigotis

      Affiliations

    • Second Department of Internal Medicine Propaedeutic, Attikon University General Hospital, Rimini 1, Chaidari, Athens, Greece
    • ,
  • J. Dervenoulas

      Affiliations

    • Second Department of Internal Medicine Propaedeutic, Attikon University General Hospital, Rimini 1, Chaidari, Athens, Greece
    • ,
  • T. Economopoulos

      Affiliations

    • Second Department of Internal Medicine Propaedeutic, Attikon University General Hospital, Rimini 1, Chaidari, Athens, Greece
    • ,
  • S. Raptis

      Affiliations

    • Second Department of Internal Medicine Propaedeutic, Attikon University General Hospital, Rimini 1, Chaidari, Athens, Greece

Received 24 June 2004 ,Accepted 24 June 2004.

References 

  1. Lloyd RV, Erickson LA, Jin L, Kulig E, Qian X, Cheville JC, et al. P27kip1: a multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers. Am. J. Pathol. 1999;154:313–323
  2. Sanchez-Beato M, Saez AI, Martinez-Montero JC, Sol Mateo M, Sanchez-Verde L, Villuendas R, et al. Cyclin-dependent kinase inhibitor p27kip1 in lymphoid tissue P27kip1 expression is inversely proportional to the proliferative index. Am. J. Pathol. 1997;151:151–160
  3. Morosetti R, Kawamata N, Gombart AF, Miller CW, Hatta Y, Hirama T, et al. Alterations of the p27kip1 gene in non-Hodgkin's lymphomas and adult T-cell Leukemia/Lymphoma. Blood. 1995;86:1924–1930
  4. Hayette S, Thomas X, Bertrand Y, Tigoud I, Callana M, Thiebaut A, et al. Molecular analysis of cyclin-dependent kinase inhibitors in human leukemias. Leukemia. 1997;11:1696–1699
  5. Kawamata N, Morosetti R, Miller CW, Park D, Spirin KS, Nakamakin T, et al. Molecular analysis of the cyclin-dpendent kinase inhibitor p27/kip 1 gene in human malignancies. Cancer Res. 1995;55:2266–2269
  6. Cave H, Martin E, Devaux I, Grandchamp B. Identification of a polymorphism in the coding region of the P27kip1 gene. Ann. Genet. 1995;38:108
  7. Russo AA, Jeffrey PD, Patten AK, Massague J, Pavletich NP. Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. Nature. 1996;382(6589):325–331
  8. Verkhivker GM, Bouzida D, Gehlhaar DK, Rejto PA, Freer ST, Rose PW. Simulating disorder-order transitions in molecular recognition of unstructured proteins: where folding meets binding. Proc Natl Acad Sci U. S. A. 2003;100:5148–5153

PII: S0145-2126(04)00240-1

doi: 10.1016/j.leukres.2004.06.007

Leukemia Research
Volume 29, Issue 2 , Pages 229-231 , February 2005

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