Leukemia Research
Volume 29, Issue 2 , Pages 147-152, February 2005

The peripheral blood Vα24+NKT cell numbers decrease in patients with haematopoietic malignancy

  • Ken-ichirou Yoneda

      Affiliations

    • The Second Department of Internal Medicine, Nara Medical University, 840 Shijo-cho, Kashihara City, Nara 634-8522, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 744 29 8854; fax: +81 744 29 0907.
    • ,
  • Takeshi Morii

      Affiliations

    • The Second Department of Internal Medicine, Nara Medical University, 840 Shijo-cho, Kashihara City, Nara 634-8522, Japan
    • ,
  • Mie Nieda

      Affiliations

    • Laboratory of Molecular Immunology, MEDINET Co., Ltd., 4-20-18 Seta Setagaya-ku, Tokyo 158-0095, Japan
    • ,
  • Nobuhiko Tsukaguchi

      Affiliations

    • The Second Department of Internal Medicine, Nara Medical University, 840 Shijo-cho, Kashihara City, Nara 634-8522, Japan
    • ,
  • Itsuto Amano

      Affiliations

    • The Second Department of Internal Medicine, Nara Medical University, 840 Shijo-cho, Kashihara City, Nara 634-8522, Japan
    • ,
  • Haruyuki Tanaka

      Affiliations

    • The Second Department of Internal Medicine, Nara Medical University, 840 Shijo-cho, Kashihara City, Nara 634-8522, Japan
    • ,
  • Hideo Yagi

      Affiliations

    • The Second Department of Internal Medicine, Nara Medical University, 840 Shijo-cho, Kashihara City, Nara 634-8522, Japan
    • ,
  • Nobuhiro Narita

      Affiliations

    • The Second Department of Internal Medicine, Nara Medical University, 840 Shijo-cho, Kashihara City, Nara 634-8522, Japan
    • ,
  • Hiroshi Kimura

      Affiliations

    • The Second Department of Internal Medicine, Nara Medical University, 840 Shijo-cho, Kashihara City, Nara 634-8522, Japan

Received 28 November 2003; accepted 1 June 2004.

Abstract 

Vα24TCR+CD161+NKT (Vα24+NKT) cells are activated by α-galactosylceramide and can exert anti-tumor activity against a variety of tumor cells. In this study, we assessed the Vα24+NKT cell numbers in peripheral blood (PB) from 30 healthy donors and 70 patients with haematopoietic malignancy including chronic myelogenous leukemia (CML), malignant lymphoma (ML), acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS). Here, we demonstrated that PB Vα24+NKT cell numbers were significantly decreased in all the patients with haematopoietic malignancy in comparison with that in healthy donors (P < 0.005). In particular CD4−CD8−Vα24+NKT cell numbers were more significantly decreased in the patients with haematopoietic malignancy (P < 0.0001).

Keywords: NKT, Vα24, CD161, Double negative, Haematopoietic malignancy, Tumor immunity

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PII: S0145-2126(04)00229-2

doi:10.1016/j.leukres.2004.06.005

Leukemia Research
Volume 29, Issue 2 , Pages 147-152, February 2005

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