High Th1/Th2 ratio in patients with multiple myeloma

Ogawara, Hatsue; Handa, Hiroshi; Yamazaki, Tohru; Toda, Takuma; Yoshida, Kensuke; Nishimoto, Natsumi; Al-ma’Quol, Wedad Hamdi Saleh; Kaneko, Yoriaki; Matsushima, Takafumi; Tsukamoto, Norifumi; Nojima, Yoshihisa; Matsumoto, Morio; Sawamura, Morio; Murakami, Hirokazu

doi:10.1016/j.leukres.2004.06.003

« Previous Next »Leukemia Research
Volume 29, Issue 2 , Pages 135-140, February 2005

High Th1/Th2 ratio in patients with multiple myeloma

Hatsue Ogawara
- Department of Laboratory Sciences, School of Health Sciences, Faculty of Medicine, Gunma University, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, Japan
Hiroshi Handa
- Department of Laboratory Sciences, School of Health Sciences, Faculty of Medicine, Gunma University, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, Japan
Tohru Yamazaki
- Department of Laboratory Sciences, School of Health Sciences, Faculty of Medicine, Gunma University, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, Japan
Takuma Toda
- Department of Laboratory Sciences, School of Health Sciences, Faculty of Medicine, Gunma University, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, Japan
Kensuke Yoshida
- Department of Laboratory Sciences, School of Health Sciences, Faculty of Medicine, Gunma University, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, Japan
Natsumi Nishimoto
- Department of Laboratory Sciences, School of Health Sciences, Faculty of Medicine, Gunma University, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, Japan
Wedad Hamdi Saleh Al-ma’Quol
- Department of Laboratory Sciences, School of Health Sciences, Faculty of Medicine, Gunma University, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, Japan
Yoriaki Kaneko
- Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Gunma, Japan
Takafumi Matsushima
- Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Gunma, Japan
Norifumi Tsukamoto
- Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Gunma, Japan
Yoshihisa Nojima
- Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Gunma, Japan
Morio Matsumoto
- Department of Internal Medicine, National Nishi-Gunma Hospital, Gunma, Japan
Morio Sawamura
- Department of Internal Medicine, National Nishi-Gunma Hospital, Gunma, Japan
Hirokazu Murakami
- Department of Laboratory Sciences, School of Health Sciences, Faculty of Medicine, Gunma University, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, Japan
- Corresponding author.

Received 19 March 2004; accepted 5 June 2004.

Abstract

To determine the clinical significance of the T helper 1(Th1)/T helper 2 (Th2) ratio in multiple myeloma, the intracellular IFN-γ and IL-4 were analyzed by flow cytometry in 56 patients with multiple myeloma. The mean Th1/Th2 ratio of cases in the initial diagnosis phase and the refractory phase were higher than that of the control group. The mean serum beta-2-microglobulin in the high Th1/Th2 subgroup was significantly higher than that in the normal Th1/Th2 subgroup (P < 0.05). In conclusion, the Th1/Th2 ratio was closely related to the disease status of multiple myeloma.

Keywords: Myeloma, T cell, Th1, Th2, Immunoglobulin