Leukemia Research
Volume 28, Issue 12 , Pages 1341-1345, December 2004

The p73 locus is commonly deleted in non-Hodgkin’s lymphomas

  • Archontoula Stoffel

      Affiliations

    • Laboratory for Cancer Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 212 327 7057; fax: +1 212 327 7058.
    • ,
  • Daniel Filippa

      Affiliations

    • Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    • ,
  • Pulivarthi H. Rao

      Affiliations

    • Laboratory of Molecular Cytogenetics, Texas Children’s Cancer Center, Baylor College of Medicine, 6621 Fannin Street, MC 3-3320, Houston, TX 77030, USA
    • Co-corresponding author. Tel.: +1 832 824 4820; fax: +1 832 825 4846.

Received 28 January 2004; accepted 21 April 2004.

Abstract 

Rearrangements involving the 1p36 chromosomal region occur frequently in NHL, suggesting the existence of tumor suppressor gene(s) that are important in lymphomagenesis. p73 is closely related to the tumor suppressor p53 and maps to the chromosome 1p36 region. Here we report heterozygous deletions of the p73 locus in 25% of FL and 27% of DLBCL cases, as detected by FISH. Immunohistochemical analysis showed that four out of five cases with p73 deletions also exhibited increased Ki67 expression, indicating higher proliferation rates of the tumor cells. Our results demonstrate a high proportion of p73 locus specific deletions in NHL and suggest that deletion of this locus may play a role in the progression of NHL.

Abbreviations:  NHL, non-Hodgkins lymphoma, FL, follicular lymphoma, DLBCL, diffuse large B-cell lymphoma, FISH, fluorescence in situ hybridization

Keywords:  Non-Hodgkins lymphoma, p73

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PII: S0145-2126(04)00178-X

doi:10.1016/j.leukres.2004.04.010

Leukemia Research
Volume 28, Issue 12 , Pages 1341-1345, December 2004

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