An association study of the tumor necrosis factor alpha C-850T polymorphism and childhood acute lymphoblastic leukemia in a population from northern Greece

Abstract 

Excessive production of tumor necrosis factor alpha (TNFα) may influence the risk and/or progression of hematologic malignancies and has been associated with febrile episodes at diagnosis. We have examined the putative association of the C-850T polymorphism of the human TNFα gene with childhood acute lymphoblastic leukemia (ALL) and with clinical and laboratory findings at diagnosis, in 58 childhood ALL patients from northern Greece. No statistically significant associations have emerged between this polymorphism and either the risk for childhood ALL or presence of fever, anemia, leukocytosis and leukopenia at diagnosis, in this study.

Keywords:  Tumor necrosis factor alpha, Gene polymorphism, Acute lymphoblastic leukemia, Clinical findings