Leukemia Research
Volume 28, Issue 10 , Pages 1001-1004, October 2004

Telomeres and telomerase in normal and leukemic hematopoietic cells

Department of Hematology/Oncology, University of Freiburg Medical Center, Hugstetterstr. 55, 79106 Freiburg, Germany

Received 14 January 2004; accepted 19 January 2004.

Abstract 

Telomere length and telomerase have an important role in normal and malignant hematopoiesis. Telomere erosion can lead to chromosome end fusion and thereby contribute to genomic instability during tumorigenesis. Thus, like complex chromosomal aberrations, telomere length may be a prognostic factor in hematopoietic malignancies. A paper by Sieglova et al. in this issue of Leukemia Research reports on the prognostic impact of telomere shortening in bone marrow (BM) and peripheral blood (PB) specimens of myelodysplastic syndrome (MDS) and MDS converted-AML patients (pts). Their results underline the importance to study telomere biology together with cytogenetics, genomic and proteomic profiling as prognostic factors, in order to improve risk-adapted therapy of MDS and AML pts.

Keywords:  Telomere, Telomerase, Genomic instability, MDS, AML

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PII: S0145-2126(04)00059-1

doi:10.1016/j.leukres.2004.01.015

Leukemia Research
Volume 28, Issue 10 , Pages 1001-1004, October 2004

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