Leukemia Research
Volume 28, Issue 10 , Pages 1089-1096 , October 2004

HI44a, an anti-CD44 monoclonal antibody, induces differentiation and apoptosis of human acute myeloid leukemia cells

Received 24 October 2003 ,Accepted 27 February 2004.

References 

  1. Hozumi M. Differentiation therapy of leukemia: achievements, limitations and future prospects. Int. J. Hematol. 1998;68:107–129
  2. Bishop JF, Matthews JP, Young GA, Szer J, Gillett A, Joshua D, et al.  A randomized study of high dose cytarabine in induction in acute myeloid leukemia. Blood. 1996;87:1710–1717
  3. Collins SJ, Ruscetti FW, Gallagher RE, Gallo RC. Terminal differentiation of human promyelocytic leukemia cells induced by dimethylsulfoxide and other polar compounds. Proc. Natl. Acad. Sci. U.S.A. 1978;75:2458–2462
  4. Liu P, Han ZC. Treatment of acute promyelocytic leukemia and other hematologic malignancies with arsenic trioxide: clinical and basic studies. Int. J. Hematol. 2003;78:32–39
  5. Degos LC, Dombret H, Chomienne C, Daniel MT, Miclea JM, Chastang C, et al.  All-trans-retinoic acid as a differentiating agent in the treatment of acute promyelocytic leukemia. Blood. 1995;85:2643–2653
  6. Tallman MS, Andersen JW, Schiffer CA, Appelbaum FR, Feusner JH, Ogden A, et al.  All-trans-retinoic acid in acute promyelocytic leukemia. N. Engl. J. Med. 1997;337:1021–1028
  7. Ponta H, Sherman L, Herrlich PA. CD44: from adhesion molecules to signaling regulators. Oncogene. 2003;4:33–45
  8. Moll J, Khaldoyanidi S, Sleeman JP, Achtnich M, Preuss I, Ponta H, et al.  Two different function for CD44 proteins in human myelopoiesis. J. Clin. Invest. 1998;102:1024–1034
  9. Ghaffari S, Dougherty GJ, Eaves AC, Eaves CJ. Altered patterns of CD44 epitope expression in human chronic and acute myeloid leukemia. Leukemia. 1996;10:1773–1781
  10. Delfino DV, Patrene KD, DeLeo AB, DeLeo R, Herberman RB, Boggs SS. Role of CD44 in the development of natural killer cells from precursors in long-term cultures of mouse bone marrow. J. Immunol. 1994;152:5171–5179
  11. Miyake K, Medina KL, Hayashi S, Ono S, Hamaoka T, Kincade PW. Monoclonal antibodies to Pgp-1/CD44 block lympho-hemopoiesis in long term bone marrow cultures. J. Exp. Med. 1990;171:477–488
  12. Ghaffari S, Dougherty GJ, Eaves AC, Eaves CJ. Diverse effects of anti-CD44 antibodies on the stromal cell-mediated support of normal but not leukemic (CML) haemopoiesis in vitro. Br. J. Haematol. 1997;97:22–28
  13. Charrad RS, Li Y, Delpech B, Balitrand N, Clay D, Jasmin C, et al.  Ligation of the CD44 adhesion molcule reverse blockage of differentiation in human acute myeloid leukemia. Nat. Med. 1999;5(6):669–676
  14. Charrad RS, Gadhoum Z, Qi J, Glachant A, Allouche M, Jasmin C, et al.  Effects of anti-CD44 monoclonal antibodies on differentiation and apoptosis of human myeloid leukemia cell lines. Blood. 2002;99:290–299
  15. Allouche M, Charrad RS, Bettaieb A, Greenland C, Grignon C, Smadja-Joffe F. Ligation of the CD44 adhesion molecule inhibit drug-induced apoptosis in human myeloid leukemia cells. Blood. 2000;96(3):1187–1190
  16. Zada AA, Singh SM, Reddy VA, Elsasser A, Meisel A, Haferlach T, et al.  Downregulation of c-Jun expression and cell cycle regulatory molecules in acute myeloid leukemia cells upon CD44 ligation. Oncogene. 2003;22:2296–2308
  17. Bruserud O, Gjertsen BT, Foss B, Huang TS. New strategies in the treatment of acute myelogenous leukemia (AML): in vitro culture of AML cells-the present use in experimental studies and the possible importance for future therapeutic approaches. Stem Cells. 2001;19:1–11
  18. Clodi K, Kliche KO, Zhao S, Weidner D, Schenk T, Consoli U, et al.  Cell-surface exposure of phosphatidylserine correlates with the stage of fludarabine-induced apoptosis in chronic lymphocytic leukemia and expression of apoptosis-regulating gene. Cytometry. 2000;40(1):19–25
  19. Clark BR, Gallagher JT, Dexter TM. Cell adhesion in the stromal regulation of haemopoiesis. Baillieres Clin. Haematol. 1992;5:619–652
  20. Aruffo A, Stamenkovic I, Melnick M, Underhill CB, Seed B. CD44 is the principal cell surface receptor for hyaluronate. Cell. 1990;61:1303–1313
  21. Miyake K, Underhill CB, Lesley J, Kincade PW. Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition. J. Exp. Med. 1990;172:69–75
  22. Khaldoyanidi S, Moll J, Karakhanova S, Herrlich P, Ponta H. Hyaluronate-enhanced hematopoiesis: two different receptors trigger the release of interleukin-1 β and interleukin-6 from bone marrow macrophages. Blood. 1999;94:940–949
  23. Ghaffari S, Dougherty GJ, Lansdorp PM, Eaves AC, Eaves CJ. Differentiation-associated changes in CD44 isoform expressing during normal hematopoiesis and their alteration in chronic myeloid leukemia. Blood. 1995;6:2976–2985
  24. Negroni A, Scarpa S, Romeo A, Ferrari S, Modesti A, Raschella G. Decrease of proliferation rate and induction of differentiation by a MYCN antisense DNA oligomer in a human neuroblastoma cell line. Cell Growth Differ. 1991;2:511–518
  25. Trumpp A, Refaeli Y, Oskarsson T, Gasser S, Murphy M, Martin GR, et al.  C-Myc regulates mammalian body size by controlling cell number but not cell size. Nature. 2001;414:768–773
  26. Bergamaschi G, Carlo-Stella C, Cazzola M, De Fazio P, Pedrazzoli P, Peverali FA, et al.  Tumor necrosis factor α downregulates c-myc mRNA expression and induces in vitro monocytic differentiation in fresh cells from patients with acute myeloblastic leukemia. Leukemia. 1990;4:426–430
  27. Mata-Greenwood E, Cuendet M, Sher D, Gustin D, Stock W, Pezzuto JM. Brusatol-mediated induction of leukemic cell differentiation and G1 arrest is associated with down-regulation of c-myc. Leukemia. 2002;16:2275–2284
  28. Adachi S, Obaya AJ, Han Z, Ramos-Desimone N, Wyche JH, Sedivy JM. c-Myc is necessary for DNA damage-induced apoptosis in the G (2) phase of the cell cycle. Mol. Cell Biol. 2001;21:4929–4937
  29. Hoffman B, Amanullah A, Shafarenko M, Liebermann DA. The proto-oncogene c-myc in hematopoietic development and leukemogenesis. Oncogene. 2002;21:3414–3421
  30. Boxer LM, Dang CV. Translocation involving c-myc and c-myc function. Oncogene. 2001;20:5595–5610
  31. Bruserud O, Gjertsen BT, Huang T. Induction of differentiation and apoptosis- a possible strategy in the treatment of adult acute myelogenous leukemia. Oncologist. 2000;5:454–462

PII: S0145-2126(04)00056-6

doi: 10.1016/j.leukres.2004.02.005

Leukemia Research
Volume 28, Issue 10 , Pages 1089-1096 , October 2004