Leukemia Research
Volume 28, Issue 10 , Pages 1107-1111 , October 2004

Acute leukemia of donor origin arising after stem cell transplantation for acute promyelocytic leukemia

  • Andrew S Daly

      Affiliations

    • Allogeneic Bone Marrow Transplant Service, Department of Medical Oncology and Hematology, Princess Margaret Hospital/University Health Network, 610 University Avenue, Toronto, Ont., Canada M5G 2M9
    • ,
  • Suzanne Kamel-Reid

      Affiliations

    • Department of Pathology, University Health Network, Department of Cellular and Molecular Biology, Ontario Cancer Institute/Princess Margaret Hospital, 610 University Avenue, Toronto, Ont., Canada M5G 2M9
    • ,
  • Jeffrey H Lipton

      Affiliations

    • Allogeneic Bone Marrow Transplant Service, Department of Medical Oncology and Hematology, Princess Margaret Hospital/University Health Network, 610 University Avenue, Toronto, Ont., Canada M5G 2M9
    • ,
  • Hans A Messner

      Affiliations

    • Allogeneic Bone Marrow Transplant Service, Department of Medical Oncology and Hematology, Princess Margaret Hospital/University Health Network, 610 University Avenue, Toronto, Ont., Canada M5G 2M9
    • ,
  • Thomas L Kiss

      Affiliations

    • Allogeneic Bone Marrow Transplant Service, Department of Medical Oncology and Hematology, Princess Margaret Hospital/University Health Network, 610 University Avenue, Toronto, Ont., Canada M5G 2M9
    • ,
  • Kathy Chun

      Affiliations

    • Department of Pathology, University Health Network, Department of Cellular and Molecular Biology, Ontario Cancer Institute/Princess Margaret Hospital, 610 University Avenue, Toronto, Ont., Canada M5G 2M9
    • ,
  • Lambert Busque

      Affiliations

    • Division of Hematology, Hospital Maisonneuve-Rosemont, Universite de Montreal, Canada
    • ,
  • Hong Chang

      Affiliations

    • Department of Laboratory Hematology, Princess Margaret Hospital, University Health Network, 610 University Avenue, Toronto, Ont., Canada M5G 2M9
    • Corresponding Author InformationCorresponding author. Tel.: +1-416-946-4635; fax: +1-416-946-4616.

Received 9 December 2003 ,Accepted 11 February 2004.

References 

  1. Nollet F, Billiet J, Selleslag D, Criel A. Standardisation of multiplex fluorescent short tandem repeat analysis for chimerism testing. Bone Marrow Transplant. 2001;28:511–518
  2. Witherspoon RP, Deeg HJ, Storb R. Secondary malignancies after marrow transplantation for leukemia or aplastic anemia. Transplantation. 1994;57:1413–1418
  3. Lowsky R, Fyles G, Minden M, Lipton J, Meharchand J, Tejpar I, et al.  Detection of donor cell derived acute myelogenous leukemia using fluorescence in situ hybridization. Br. J. Haematol. 1996;93:163–165
  4. Cooley LD, Sears DA, Udden MM, Harrison WR, Baker KR. Donor cell leukemia: report of a case occurring 11 years after allogeneic bone marrow transplantation and review of the literature. Am. J. Hematol. 2000;63:46–53
  5. Cransac M, Boiron J-M, Merel P, Cony-Makhoul P, Marit G, Bernard P, et al.  Burkitt-type acute lymphoblastic leukemia in donor cells after allogeneic bone marrow transplantation for acute nonlymphoblastic leukemia. Transplantation. 1993;56:120–123
  6. Feig SA, Dreazen O, Simon M, Wiley F, Schreck R, Gale RP. B cell acute lymphoblastic leukemia (ALL) in donor cells following bone marrow transplantation for T cell ALL. Bone Marrow Transplant. 1988;3:331–337
  7. Browne PV, Lawler M, Humphries P, McCann SR. Donor cell leukemia after bone marrow transplantation for severe aplastic anemia. N. Engl. J. Med. 1991;325:710–713
  8. Katz F, Reeves BR, Alexander S, Kearney L, Chessells J. Leukaemia arising in donor cells following allogeneic bone marrow transplantation for β thalassaemia demonstrated by immunological, DNA and molecular cytogenetic analysis. Br. J. Haematol. 1993;85:326–331
  9. Palka G, Di Bartolomeo P, Iacone A, Di Girolamo G, Betti S, Calabrese G, et al.  Cytogenetics and bone marrow transplantation. Cancer Genet Cytogenet. 1986;21:147–157
  10. Minden MD, Messner HA, Belch A. Origin of leukemic relapse after bone marrow transplantation detected by restriction fragment length polymorphism. J. Clin. Invest. 1985;75:91–93
  11. Anastasi J, Thangavelu M, Vardiman JW, Hooberman AL, Bian ML, Larson RA, et al.  Interphase cytogenetic analysis detects minimal residual disease in a case of acute lymphoblastic leukemia and resolves the question of origin of relapse after allogeneic bone marrow transplantation. Blood. 1991;77:1087–1091
  12. Hambach L, Eder M, Dammann E, Battmer K, Stucki A, Heil G, et al.  Donor cell-derived acute myeloid leukemia developing 14 months after matched unrelated bone marrow transplantation for chronic myeloid leukemia. Bone Marrow Transplant. 2001;28:705–707
  13. Turhan A, Humphries RK, Phillip GL, Eaves AC, Eaves CJ. Clonal hematopoiesis demonstrated by X-linked DNA polymorphisms after allogeneic bone marrow transplantation. N. Engl. J. Med. 1989;320:1655–1661
  14. Thornley I, Sutherland DR, Nayar R, Sung L, Freedman MH, Messner HA. Replicative stress after allogeneic bone marrow transplantation: changes in cycling of CD34+ CD90+ and CD34+CD90-hematopoietic progenitors. Blood. 2001;97:1876–1878

PII: S0145-2126(04)00055-4

doi: 10.1016/j.leukres.2004.02.003

Leukemia Research
Volume 28, Issue 10 , Pages 1107-1111 , October 2004

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