Leukemia Research
Volume 28, Issue 10 , Pages 1085-1088 , October 2004

Enhanced antitumor immunity by murine cytokine activated T lymphocytes after cocultured with bone marrow derived dendritic cells pulsed with whole tumor lysates

  • Sheng Zhang

      Affiliations

    • Department of Medical Oncology, Medical School Hospital of Qingdao University, 16 Jiangsulu, Qingdao 266003, China
    • Corresponding Author InformationCorresponding author. Tel.: +86-532-2795520; fax: +86-533-3166216.
    • ,
  • Qin Wang

      Affiliations

    • Department of Medical Cardiology, Zibo Central Hospital, Zibo 255000, China
    • ,
  • Wen-Feng Li

      Affiliations

    • Department of Medical Oncology, Medical School Hospital of Qingdao University, 16 Jiangsulu, Qingdao 266003, China
    • ,
  • Hong-Yi Wang

      Affiliations

    • Department of Hematology, Medical School Hospital of Qingdao University, 16 Jiangsulu, Qingdao 266003, China
    • ,
  • Hong-Jun Zhang

      Affiliations

    • Department of Medical Oncology, Medical School Hospital of Qingdao University, 16 Jiangsulu, Qingdao 266003, China

Received 9 April 2003 ,Accepted 29 January 2004.

References 

  1. Schmidt-Wolf IGH, Negrin RS, Kiem H-P, Blume KG, Weissman IL. Use of a SCID mouse/human lymphoma model to evaluate cytokine-induced killer cells with potent antitumor cell activity. J. Exp. Med. 1991;174:139–149
  2. Fields RS, Shimizu K, Mule JJ. Murine dendritic cells pulsed with whole tumor lysates mediate potent antitumor immune response in vitro and in vivo. Proc. Natl. Acad. Sci. U.S.A. 1998;95:9482–9487
  3. You S, Maeda S, Murao S, Takahashi R, Ishikawa J, Miyazawa M, et al.  Establishment and characterization of mouse leukemia cell lines L615K and L7212K derived from transplantable murine leukemias maintained in China. Jpn. J. Cancer Res. 1989;80:444–451
  4. Schmidt-Wolf IGH, Lefterova P, Mehta BA, Fernandez LP, Huhn D, Blume KG, et al.  Phenotypic characterization and identification of effector cells involved in tumor cell recognition of cytokine-induced killer cells. Exp. Hematol. 1993;21:1673–1679
  5. Fernandez NC, Lozier A, Flament C, Ricciardi-Castagnoli P, Bellet D, Suter M, et al.  Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo. Nat. Med. 1999;5:405–411
  6. Marten A, Ziske C, Schottker B, Renoth S, Weineck S, Buttgereit P, et al.  Interactions between dendritic cells and cytokine-induced killer cells lead to an activation of both populations. J. Immunother. 2001;24:502–510

PII: S0145-2126(04)00054-2

doi: 10.1016/j.leukres.2004.01.014

Leukemia Research
Volume 28, Issue 10 , Pages 1085-1088 , October 2004

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