Leukemia Research
Volume 28, Issue 10 , Pages 1033-1038 , October 2004

High frequency of t(12;21)(p13;q22) in children with acute lymphoblastic leukemia and known clinical outcome in southern Brazil

  • Loraine Beatriz Acosta Veiga

      Affiliations

    • Departamento de Genética, Laboratório de Citogenética Humana, Universidade Federal do Paraná, Centro Politecnico, Jardim das Americas, Curitiba, PR 81531, Brazil
    • ,
  • Virginia Maria Cóser

      Affiliations

    • Departamento de Hematologia/Oncologia, Laboratório de Citogenética Humana, Hospital Universitário, Universidade Federal de Santa Maria, Santa Maria, RS, Campus Universitário—Camobi, Santa Maria, RS 97119, Brazil
    • ,
  • Luciane Regina Cavalli

      Affiliations

    • Institute for Molecular and Human Genetics/Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road, NW M4000, Washington, DC 20007, USA
    • ,
  • Iglenir João Cavalli

      Affiliations

    • Departamento de Genética, Laboratório de Citogenética Humana, Universidade Federal do Paraná, Centro Politecnico, Jardim das Americas, Curitiba, PR 81531, Brazil
    • ,
  • Jacqueline Nunes Rodrigues

      Affiliations

    • Departamento de Hematologia/Oncologia, Laboratório de Citogenética Humana, Hospital Universitário, Universidade Federal de Santa Maria, Santa Maria, RS, Campus Universitário—Camobi, Santa Maria, RS 97119, Brazil
    • ,
  • Waldir Veiga Pereira

      Affiliations

    • Departamento de Hematologia/Oncologia, Laboratório de Citogenética Humana, Hospital Universitário, Universidade Federal de Santa Maria, Santa Maria, RS, Campus Universitário—Camobi, Santa Maria, RS 97119, Brazil
    • ,
  • Dalnei Veiga Pereira

      Affiliations

    • Departamento de Hematologia/Oncologia, Laboratório de Citogenética Humana, Hospital Universitário, Universidade Federal de Santa Maria, Santa Maria, RS, Campus Universitário—Camobi, Santa Maria, RS 97119, Brazil
    • ,
  • Thereza Christina Sampaio Lafayette

      Affiliations

    • Departamento de Hematologia/Oncologia, Laboratório de Citogenética Humana, Hospital Universitário, Universidade Federal de Santa Maria, Santa Maria, RS, Campus Universitário—Camobi, Santa Maria, RS 97119, Brazil
    • ,
  • Benônio Terra Villalba

      Affiliations

    • Departamento de Hematologia/Oncologia, Laboratório de Citogenética Humana, Hospital Universitário, Universidade Federal de Santa Maria, Santa Maria, RS, Campus Universitário—Camobi, Santa Maria, RS 97119, Brazil
    • ,
  • Mauber Eduardo Schultz Moreira

      Affiliations

    • Departamento de Hematologia/Oncologia, Laboratório de Citogenética Humana, Hospital Universitário, Universidade Federal de Santa Maria, Santa Maria, RS, Campus Universitário—Camobi, Santa Maria, RS 97119, Brazil
    • ,
  • Bassem R Haddad

      Affiliations

    • Institute for Molecular and Human Genetics/Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road, NW M4000, Washington, DC 20007, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-202-444-0759; fax: +1-202-444-1770.
    • ,
  • Enilze Maria de Souza Fonseca Ribeiro

      Affiliations

    • Departamento de Genética, Laboratório de Citogenética Humana, Universidade Federal do Paraná, Centro Politecnico, Jardim das Americas, Curitiba, PR 81531, Brazil
    • Co-corresponding author.

Received 4 November 2003 ,Accepted 9 February 2004.

References 

  1. Raimondi SC, Williams DL, Callihan T, Peiper S, Rivera GK, Murphy SB. Nonrandom involvement of the 12p12 breakpoint in chromosome abnormalities of childhood acute lymphoblastic leukemia. Blood. 1986;68:69–75
  2. Raimondi SC. Current status of cytogenetic research in childhood acute lymphoblastic leukemia. Blood. 1993;81:2237–2251
  3. Raimondi SC, Mathew S, Pui CH. Cytogenetics as a diagnostic aid for childhood hematologic disorders. In: Hanausek Mwalaszek Z, editors. Methods in molecular medicine, tumors markers protocols. vol. 14. Totowa, NJ: Humana Press; 1998. p. 209–27.
  4. Golub TR, Barker GF, Lovett M, Gilliland DG. Fusion of PDGF receptor β to a novel ets-like gene, TEL, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell. 1994;77:307–316
  5. Romana SP, Le Coniat M, Berger R. t(12:21): a new recurrent translocation in acute lymphoblastic leukemia. Genes Chrom Cancer. 1994;9:186–191
  6. Wiemels JL, Greaves M. Structure and possible mechanisms of TEL/AML1 gene fusion in childhood acute lymphoblastic leukemia. Cancer Res. 1999;59:4075–4082
  7. Shurtleff AS, Buijs A, Behm FG, Rubnitz JE, Raimondi SC, Hancock ML, et al.  TEL/AML1 fusion resulting from a cryptic t(12:21) is the most common genetic lesion in pediatric ALL and a subgroup of patients with an excellent prognosis. Leukemia. 1995;9:1985–1989
  8. Golub TR, Barker GF, Bohlander SK, Hiebert SW, Ward DC, Bray-Ward P, et al.  Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. Proc Natl Acad Sci USA. 1995;92:4917–4921
  9. Liang DC, Chou TB, Chen JS, Shurtleff SA, Rubnitz JE, Downing JR, et al.  High incidence of TEL/AML1 fusion resulting from a cryptic t(12:21) in childhood B-lineage acute lymphoblastic leukemia in Taiwan. Leukemia. 1996;10:991–993
  10. Harbott J, Viehmann S, Borkhardt A, Henze G, Lampert F. Incidence of TEL/AML1 fusion gene analyzed consecutively in children with acute lymphoblastic leukemia in relapse. Blood. 1997;90:4933–4937
  11. Rubnitz JE, Downing JR, Pui CH, Shurtleff AS, Raimondi SC, Evans WE, et al.  TEL gene rearrangement in acute lymphoblastic leukemia: a new genetic marker with prognostic significance. J Clin Oncol. 1997;15:1150–1157
  12. Brandalise SR, Odone-Filho V, Pereira WV, D’Andrea MLM, Zanichelli MA Anarenga V. Treatment results of three consultive brazilian cooperative childhood ALL protocols: GBTLI-80, GBTLI-82 and -85, Leukemia 1993;7:(Suppl 2):142–45.
  13. Ribeiro EM, Cavalli IJ, Schmid AT, Cornelio DA, Tokutake AS, Sperandio-Roxo VM, et al.  Cytogenetic analysis in human bone marrow transplantation. Cancer Genet Cytogenet. 1996;89(1):21–26
  14. Mitelman F, editor. ISCN, an international system for human genetic nomenclature. Basel: S. Karger; 1995.
  15. Hardwick M, Cavalli LR, Barlow KD, Haddad BR, Papadopoulos V. Peripheral-type benzodiazepine receptor (PBR) gene amplification in MDA-MB-231 aggressive breast cancer cells. Cancer Genet Cytogenet. 2002;139:48–51
  16. Beiguelman B. Curso Prático de Bioestatı́stica. Ribeirão Preto, SP: Brazilian Journal of Genetics; 1988.
  17. Borkhardt A, Cazzaniga G, Viehmann S, Valsecchi MG, Ludwig WD, Burci L, et al.  Incidence and clinical relevance of TEL/AML1 fusion genes in children with acute lymphoblastic leukemia enrolled in the German and Italian multicenter therapy trials. Blood. 1997;90:571–577
  18. Cavé H, Caheux V, Raynaud S, Brunie G, Bakkus M, Cochaux P, et al.  ETV6 is the target of chromosome 12p deletions in t(12:21) childhood acute lymphoblastic leukemia. Leukemia. 1997;11:1459–1464
  19. Spathas DH, Stewwart J, Singer IO, Theriault A, Bovey M, Connor JM. Detection of t(12:21) in childhood acute lymphoblastic leukemia by fluorescence in situ hybridization. Cancer Genet Cytogenet. 1999;110:7–13
  20. Inamdar N, Kumar AS, Banavali SD, Advani S, Magrath I, Bhatia K. Comparative incidence of the rearrangements of TEL/AML1 and ALL1 genes in pedriatric precursor B acute lymphoblastic leukemias in India. Int J Oncol. 1998;13:1319–1322
  21. Park KU, She CJ, Shin HY, Ahn HS, Kim CJ, Cho BK, et al.  Low incidence of TEL/AML1 fusion and TEL deletion in Korean childhood acute leukemia by extra-signal fluorescence in situ hybridization. Cancer Genet Cytogenet. 2001;126:73–77
  22. Garcia-Sanz R, Alaejos I, Orfao A, Rasilio A, Chillon MC, Tabernero MD, et al.  Low frequency of the TEL/AML1 fusion gene in acute lymphoblastic leukaemia in Spain. Br J Haematol. 1999;107:667–669
  23. Sawinska M, Ladon D. Mechanism, detection and clinical significance of the reciprocal translocation t(12,21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia. Leuk Res 2004;28:35–42.
  24. Zen PRG, Lima MC, Cóser VM, Silla L, Daudt L, Fernandes MS, et al. Prevalence of TEL/AML1 (ETV6/CBFA2) fusion identified by fluorescence in situ hybridization in Brazilian pediatric patients with acute lymphoblastic leukemia. Cancer Genet Cytogenet 2003, in press.
  25. Yehuda-Gafni O, Cividalli G, Abrahmov A, Weintrob M, Neriah SB, Cohen R, et al.  Fluorescence in situ hybridization analysis of the cryptic t(12:21)(p13;q22) in childhood B-lineage acute lymphoblastic leukemia. Cancer Genet Cytogenet. 2002;132:61–64
  26. Douet-Guilbert N, Morel F, Le Bris MJ, Herry A, Calvez GL, Marion V, et al.  A fluorescence in situ hybridization study of TEL-AML1 fusion gene in B-cell acute lymphoblastic leukemia (1984–2001). Cancer Genet Cytogenet. 2003;144:143–147
  27. Martinez-Ramirez A, Urioste M, Contra T, Cantalejo A, Tavares A, Portejo JA, et al.  Fluorescence in situ hybridization study of TEL/AML1 fusion and other abnormalities involving TEL and AML1 genes: correlation with cytogenetic findings and prognostic value in children with acute lymphoblastic leukemia. Haematologica. 2001;86:1245–1253
  28. Busson-Le Coniat M, Nguyen KF, Daniel MT, Bernard AO, Berger R. Chromosome 21 abnormalities with AML1 amplification in acute lymphoblastic leukemia. Genes Chrom Cancer. 2001;32:244–249
  29. Jamil A, Theil KS, Kahwash S, Ruymann FB, Klopfenstein KJ. TEL/AML-1 fusion gene: its frequency and prognostic significance in childhood acute lymphoblastic leukemia. Cancer Genet.Cytogenet. 2000;122:73–78

PII: S0145-2126(04)00051-7

doi: 10.1016/j.leukres.2004.02.004

Leukemia Research
Volume 28, Issue 10 , Pages 1033-1038 , October 2004

Article Tools

* Image Usage & Resolution