Leukemia Research
Volume 28, Issue 10 , Pages 1039-1041 , October 2004

Methylenetetrahydrofolate reductase genotype does not play a role in adult T-cell leukemia/lymphoma pathogenesis among human T-lymphotrophic virus type 1 carriers

  • Seisho Takeuchi

      Affiliations

    • Department of Medicine, Kochi Medical School, Kochi University, Okoh-cho, Nankoku, Kochi 783-8505, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-888-80-2553; fax: +81-888-80-2518.
    • ,
  • Naoko Takeuchi

      Affiliations

    • Division of Hematology/Oncology, Cedars-Sinai Research Institute, UCLA School of Medicine, Los Angeles, CA 90048, USA
    • ,
  • Kunihiro Tsukasaki

      Affiliations

    • Molecular Medicine Unit, Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Nagasaki 852-8523, Japan
    • ,
  • Yang Yang

      Affiliations

    • Department of Medicine, Kochi Medical School, Kochi University, Okoh-cho, Nankoku, Kochi 783-8505, Japan
    • ,
  • Anthony C Fermin

      Affiliations

    • Division of Hematology/Oncology, Cedars-Sinai Research Institute, UCLA School of Medicine, Los Angeles, CA 90048, USA
    • ,
  • Masao Tomonaga

      Affiliations

    • Molecular Medicine Unit, Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Nagasaki 852-8523, Japan
    • ,
  • Carl W Miller

      Affiliations

    • Division of Hematology/Oncology, Cedars-Sinai Research Institute, UCLA School of Medicine, Los Angeles, CA 90048, USA
    • ,
  • Hiromi Seo

      Affiliations

    • Department of Medicine, Kochi Medical School, Kochi University, Okoh-cho, Nankoku, Kochi 783-8505, Japan
    • ,
  • H.Phillip Koeffler

      Affiliations

    • Division of Hematology/Oncology, Cedars-Sinai Research Institute, UCLA School of Medicine, Los Angeles, CA 90048, USA

Received 29 August 2003 ,Accepted 9 February 2004.

References 

  1. Uchiyama T, Yodoi J, Sagawa K, Takatsuki K, Uchino H. Adult T-cell leukemia: clinical and hematological features of 16 cases. Blood. 1977;50:481–492
  2. Tajima K, Kamura S, Ito S, Nagatomo M, Kinoshita K, Ikeda S. Epidemiology features of HTLV-1 carriers and incidence of ATL in an ATL-endemic island: a report of the community based co-operative study in Tsushima, Japan. Int. J. Cancer. 1987;40:741–746
  3. Okamoto T, Ohno Y, Tsugane S, Watanabe S, Shomoyama M, Tajima K, et al.  Multi-step carcinogenesis model for adult T-cell leukemia. Jpn. J. Cancer Res. 1989;80:191–195
  4. Hatta Y, Koeffler HP. Role of tumor suppressor genes in the development of adult T cell leukemia/lymphoma (ATLL). Leukemia. 2002;16:1069–1085
  5. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, et al.  A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat. Genet. 1995;10:111–113
  6. van der Put NM, Gabreels F, Stevens EM, Smeitink JA, Trijbels FJ, Eskes TK, et al.  A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?. Am. J. Human Genet. 1998;62:1044–1051
  7. Matsuo K, Suzuki R, Hamajima N, Ogura M, Kagami Y, Taji H, et al.  Association between polymorphisms of folate- and methionine-metabolizing enzymes and susceptibility to malignant lymphoma. Blood. 2001;97:3205–3209
  8. Tsukasaki K, Miller CW, Kubota T, Takeuchi S, Fujimoto T, Ikeda S, et al.  Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers. Cancer Res. 2001;61:3770–3774
  9. Skibola CF, Smith MT, Kane E, Roman E, Rollinson S, Cartwright RA, et al.  Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults. Proc. Natl. Acad. Sci. U.S.A. 1999;96:12810–12815
  10. Wiemels JL, Smith RN, Taylor GM, Eden OB, Alexander FE, Greaves MF. United Kingdom Childhood Cancer Study investigators. Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia. Proc. Natl. Acad. Sci. U.S.A. 2001;98:4004–4009
  11. Lincz LF, Scorgie FE, Kerridge I, Potts R, Spencer A, Enno A. Methionine synthase genetic polymorphism MS A2756G alters susceptibility to follicular but not diffuse large B-cell non-Hodgkin’s lymphoma or multiple myeloma. Brit. J. Haematol. 2003;120:1051–1054
  12. González-Fraile MI, Garcı́a-Sanz R, Mateos MV, Balanzategui A, González M, Váquez L, et al.  Methylenetetrahydrofolate reductase genotype does not play a role in multiple myeloma pathogenesis. Brit. J. Haematol. 2002;117:890–892

PII: S0145-2126(04)00050-5

doi: 10.1016/j.leukres.2004.02.001

Leukemia Research
Volume 28, Issue 10 , Pages 1039-1041 , October 2004

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