Leukemia Research
Volume 28, Issue 10 , Pages 1039-1041, October 2004

Methylenetetrahydrofolate reductase genotype does not play a role in adult T-cell leukemia/lymphoma pathogenesis among human T-lymphotrophic virus type 1 carriers

  • Seisho Takeuchi

      Affiliations

    • Department of Medicine, Kochi Medical School, Kochi University, Okoh-cho, Nankoku, Kochi 783-8505, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-888-80-2553; fax: +81-888-80-2518.
    • ,
  • Naoko Takeuchi

      Affiliations

    • Division of Hematology/Oncology, Cedars-Sinai Research Institute, UCLA School of Medicine, Los Angeles, CA 90048, USA
    • ,
  • Kunihiro Tsukasaki

      Affiliations

    • Molecular Medicine Unit, Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Nagasaki 852-8523, Japan
    • ,
  • Yang Yang

      Affiliations

    • Department of Medicine, Kochi Medical School, Kochi University, Okoh-cho, Nankoku, Kochi 783-8505, Japan
    • ,
  • Anthony C Fermin

      Affiliations

    • Division of Hematology/Oncology, Cedars-Sinai Research Institute, UCLA School of Medicine, Los Angeles, CA 90048, USA
    • ,
  • Masao Tomonaga

      Affiliations

    • Molecular Medicine Unit, Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Nagasaki 852-8523, Japan
    • ,
  • Carl W Miller

      Affiliations

    • Division of Hematology/Oncology, Cedars-Sinai Research Institute, UCLA School of Medicine, Los Angeles, CA 90048, USA
    • ,
  • Hiromi Seo

      Affiliations

    • Department of Medicine, Kochi Medical School, Kochi University, Okoh-cho, Nankoku, Kochi 783-8505, Japan
    • ,
  • H.Phillip Koeffler

      Affiliations

    • Division of Hematology/Oncology, Cedars-Sinai Research Institute, UCLA School of Medicine, Los Angeles, CA 90048, USA

Received 29 August 2003; accepted 9 February 2004.

Abstract 

Human T-lymphotropic virus type 1 (HTLV-1) is associated with adult T-cell leukemia/lymphoma (ATL). However, the incidence of ATL is low among HTLV-1 carriers suggesting additional mechanisms are involved in the progression of the disease. A recent study found that polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene influence the susceptibility to malignant lymphoma. We have analyzed the MTHFR genotype in 81 HTLV-1 carriers and 87 ATL patients. No statistically significant associations were found between MTHFR genotype and development of ATL. These data suggest that genetic polymorphisms in the MTHFR locus do not play a role in ATL pathogenesis among HTLV-1 carriers.

Abbreviations:  ATL, adult T-cell leukemia/lymphoma, HTLV-1, human T-lymphotropic virus type 1, MTHFR, methylenetetrahydrofolate reductase, RFLP, restriction fragment length polymorphisms

Keywords:  MTHFR, ATL, HTLV-1, Polymorphisms, Molecular epidemiology

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PII: S0145-2126(04)00050-5

doi:10.1016/j.leukres.2004.02.001

Leukemia Research
Volume 28, Issue 10 , Pages 1039-1041, October 2004

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