Leukemia Research
Volume 28, Issue 8 , Pages 879-889 , August 2004

Delayed-late activation of a myeloid defensin minimal promoter by retinoids and inflammatory mediators

  • Nan Wang

      Affiliations

    • Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    • ,
  • Qin Su

      Affiliations

    • Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    • ,
  • Susanne Boeckh-Herwig

      Affiliations

    • Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    • ,
  • Mariana Yaneva

      Affiliations

    • Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    • ,
  • Paul Tempst

      Affiliations

    • Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    • Weill Graduate School of Medical Sciences, Cornell University, New York, NY 10021, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-212-639-8923; fax: +1-212-717-3604.

Received 25 August 2003 ,Accepted 12 December 2003.

References 

  1. Koeffler HP. Induction of differentiation of human acute myelogenous leukemia cells: therapeutic implications. Blood. 1983;62:709–721
  2. Collins SJ. The HL-60 promyelocytic leukemia cell line: proliferation. Blood. 1987;70:1233–1244
  3. Breitman TR, Selonick SE, Collins SJ. Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid. Proc. Natl. Acad. Sci. U.S.A. 1980;77:2936–2940
  4. Herwig S, Su Q, Zhang W, Ma Y, Tempst P. Distinct temporal patterns of defensin mRNA regulation during drug-induced differentiation of human myeloid leukemia cells. Blood. 1996;87:350–364
  5. Lehrer RI, Lichtenstein AK, Ganz T. Defensins, antimicrobial and cytotoxic peptides of mammalian cells. Ann. Rev. Immunol. 1993;11:105–128
  6. Lehrer RI, Ganz T. Defensins of vertebrate animals. Curr. Opin. Immunol. 2002;4:96–102
  7. Zhang L, Yu W, He T, Yu J, Caffrey RE, Dalmano EA, et al.  Contribution of human α-defensin 1, 2, and 3 to the anti-HIV-1 activity of CD8 antiviral factor. Science. 2002;298:995–1000
  8. Wiedemann LM, Francis GE, Lamb RF, Burns JH, Winnie JN, McKenzie ED, et al.  Differentiation stage-specific expression of a gene during granulopoiesis. Leukemia. 1989;3:227–234
  9. Mars WM, Florine DL, Talpaz M, Saunders GF. Preferentially expressed genes in chronic myelogenous leukemia. Blood. 1985;65:1218–1225
  10. Ma Y, Su Q, Tempst P. Differentiation-stimulated activity binds an ETS-like, essential regulatory element in the human promyelocytic defensin-1 promoter. J. Biol. Chem. 1998;273:8727–8740
  11. Tsutsumi-Ishii Y, Hasebe T, Nagaoka I. Role of CCAAT/enchancer-binding protein site in transcription of human neutrophil peptide-1 and -3 defensin genes. J. Immunol. 2000;164:3264–3273
  12. Herwig S, Su Q, Tempst P. Drug-activated multiple pathway of defensin mRNA regulation in HL-60 cells are defined by reversed roles of participating protein kinases. Leukemia Res. 1998;22:913–925
  13. Tenen DG, Hromas R, Licht JD, Zhang D-E. Transcription factors, normal myeloid development, and leukemia. Blood. 1997;90:489–519
  14. Friedman AD. Transcriptional regulation of granulocyte and monocyte development. Oncogene. 2002;21:3377–3390
  15. Holmberg CI, Tran SEF, Eriksson JE, Sistonen L. Multisite phosphorylation provides sophisticated regulation of transcription factors. TIBS. 2002;27:619–627
  16. Daher KA, Lehrer RI, Ganz T, Kronenberg M. Isolation and characterization of human defensin cDNA clones. Proc. Natl. Acad. Sci. U.S.A. 1988;85:7327
  17. Zhang D-E, Heterington CJ, Chen H-M, Tenen DG. The macrophage transcription factor PU.1 directs tissue-specific expression of the MCSF receptor. Mol. Cell. Biol. 1994;14:373–381
  18. Lalli E, Sassoni-Corsi P. Signal transduction and gene regulation: the nuclear response to cAMP. J. Biol. Chem. 1994;269:17359–17362
  19. Sweet MJ, Hume DA. Endotoxin singal transduction in macrophages. J. Leukocyte Biol. 1996;60:8–26
  20. Guha M, Mackman N. LPS induction of gene expression in human monocytes. Cell Signal. 2001;13:85–94
  21. Baud V, Karim M. Signal transduction by tumor necrosis factor and its relatives. TICB. 2001;11:372–377
  22. Reinhard C, Shamoon B, Shyamala V, Williams LT. Tumor necrosis factor a-induced activation of c-jun N-terminal kinase is mediated by TRAF2. EMBO J. 1997;16:1080–1092
  23. Bialojan C, Takai A. Inbibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Biochem. J. 1988;256:283–290
  24. Dounay AB, Forsyth CJ. Okadaic Acid: the archetypal serine-threonine protein phosphatase inhibitor. Curr. Med. Chem. 2002;9:1939–1980
  25. Rohlff C, Ahmad S, Borellini F, Lei J, Glazer RI. Modulation of transcription factor Sp1 by cAMP-dependent protein kinase. J. Biol. Chem. 1997;272:21137–21141
  26. Zhong H, Yang HS, Erdjument-Bromage H, Tempst P, Ghosh S. The transcriptional activity of NF-κB is regulated by the IκB-associated PKAc subunit through a cAMP-independent mechanism. Cell. 1997;89:413–424
  27. Tsai EY, Falvo JV, Tsytsykova AV, Barczak AK, Reimold AM, Glimcher LH, et al.  A lipopolysaccharide-specific enchancer complex involving Ets, Elk-1, Sp1, and CREB binding protein and p300 is recruited to the tumor necrosis factor alpha promoter in vivo. Mol. Cell. Biol. 2000;20:6084–6094
  28. Groupp ER, Donovan-Peluso M. Lipopolysaccharide induction of THP-1 cells activates binding oc c-Jun, Ets, and Egr-1 to the tissue factor promoter. J. Biol. Chem. 1996;271:12423–12430
  29. Shackelford R, Adams DO, Johnson SP. IFN-gamma and lipopolysacchride induce DNA binding of transcription factor PU.1 in murine tissue macrophages. J. Immunol. 1995;154:1374–1382
  30. Lodie TA, Savedra R, Golenbock DT, Van Beveren CP, Maki RA, Fenton MJ. Stimulation of macrophages by lipopolysacchride alters the phosphorylation state, conformation. J. Immunol. 1997;158:1848–1856
  31. Dusi S, Donini M, Lissandrini D, Mazzi P, Bianca VD, Rossi F, et al.  Mechanisms of expression of NADPH oxidase components in human cultured monocytes: role of cytokines and transcriptional regulations involved. Eur. J. Immunol. 2001;31:929–938
  32. Pevzner V, Kraft R, Kostka S, Lipp M. Phosphorylation of Oct-2 at sites located in the POU domain induces differential down-regulation of Oct-2 DNA-binding ability. Biochem. J. 2000;347:29–35
  33. Finch JS, Rosenberger SF, Martinez JD, Bowden GT. Okadaic acid induces transcription of junB through a CCAAT box and NF-Y. Genetics. 2001;267:135–144
  34. Sementchenko VI, Watson DK. Ets target genes: past, present and future. Oncogene. 2000;19:6533–6548
  35. Skalnik DG. Transcriptional mechanisms regulating myeloid-specific genes. Genetics. 2002;284:1–21
  36. Mao C, Ray-Gallet D, Tavitian A, Moreau-Gachelin F. Differential phosphorylations of Spi-B and Spi-1 transcription factors. Oncogene. 1996;12:863–873
  37. Rieske P, Pongubala JMR. AKT Induces transcriptional activity of PU.1 through phosphorylation-mediated modifications within its transactivation domain. J. Biol. Chem. 2001;276:8460–8468

PII: S0145-2126(03)00423-5

doi: 10.1016/j.leukres.2003.12.005

Leukemia Research
Volume 28, Issue 8 , Pages 879-889 , August 2004

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