Leukemia Research
Volume 28, Issue 8 , Pages 863-868 , August 2004

Forced expression of AML1–AMP19, a fusion transcript generated from a radiation-associated t(19;21) leukemia, blocks myeloid differentiation

  • Heather Ramsey

      Affiliations

    • Cancer Research and Treatment Center, University of New Mexico Health Science Center, 900 Camino de Salud, Albuquerque, NM 87131, USA
    • ,
  • Kent Christopherson

      Affiliations

    • Department of Microbiology and Immunology, The Walther Oncology Center, Indiana University Medical Center, Indianapolis, IN 46202, USA
    • ,
  • Robert Hromas

      Affiliations

    • Cancer Research and Treatment Center, University of New Mexico Health Science Center, 900 Camino de Salud, Albuquerque, NM 87131, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-505-272-5837; fax: +1-505-272-5865.

Received 19 September 2003 ,Accepted 14 December 2003.

References 

  1. Akam M. Hox and HOM: homologous gene clusters in insects and vertebrates. Cell. 1993;57:347–349
  2. Reid L. From gradients to axes, from morphogenesis to differentiation. Cell. 1990;63:875–882
  3. Darnell J. Variety in the level of gene control in eukaryotic cells. Nature. 1982;297:365–372
  4. Kuo CJ, Conley PB, Chen L, Sladek FM, Darnell J, Crabtree GR. A transcriptional hierarchy involved in mammalian cell type specification. Nature. 1992;335:457–461
  5. Mitchell PJ, Tijan R. Transcriptional regulation in mammalian cells by sequence-specific DNA-binding proteins. Science. 1989;245:371–378
  6. Johnson PF, McKnight S. Eukaryotic transcriptional regulatory proteins. Ann. Rev. Biochem. 1989;58:799–821
  7. Van der Reiden BA, Bloomfield CD, Touw IP, Jansen JH. Acute leukemias with structurally altered core binding factor subunits: t(8;21), inv(16), and t(12;21)—meeting report. Leukemia. 1997;11:2217
  8. Roulston D, Espinosa R, Nucifora G, Larson RA, Le Beau MM, Rowley JD. CBFα2 (AML1) translocations with novel partner chromosomes in myeloid leukemia: association with prior therapy. Blood. 1998;92:2879
  9. Hromas R, Shopnick R, Jumean HG, Bowers C, Varella-Garcia M, Richkind K. A novel syndrome of radiation-associated acute myeloid leukemia involving AML1 gene translocations. Blood. 2000;95:4011
  10. Hromas R, Busse T, Carroll A, Mack D, Shopnick R, Zhang D-E, et al.  Fusion AML1 transcript in a radiation-associated leukemia results in a truncated inhibitory AML1 protein. Blood. 2001;97:2168–2170
  11. Zent CS, Mathieu C, Claxton DF, Zhang DE, Tenen DG, Rowley JD, et al.  The chimeric genes AML1–MDS1 and AML1–EAP inhibit AML1B activation at the CSF1R promoter, but only AML1–MDS1 has tumor-promoter properties. Proc. Natl. Acad. Sci. U.S.A. 1996;93:1044–1048
  12. Osato M, Asou N, Abdalla F, Hoshino K, Yamasaki H, Okubo T, et al.  Biallelic and heterozygous point mutations in the runt domain of the AML1–PEBP2αB gene associated with myeloblastic leukemias. Blood. 1999;93:1817–1824
  13. Harada H, Harada Y, Tanaka H, Kimura A, Inaba T. Implications of somatic mutations in the AML1 gene in radiation-associated and therapy-related myelodysplastic syndrome/acute myeloid leukemia. Blood. 2003;101:673–680
  14. Preudhomme C, Warot-Loze D, Roumier C, Grardel-Duflos N, Garand R, Lai JL, et al.  High incidence of biallelic point mutations in the Runt domain of the AML1–PEBP2αB gene in Mo acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21. Blood. 2000;96:2862–2869
  15. Ramsey H, Zhang DE, Richkind K, Burcoglu-O’Ral A, Hromas R. Fusion of AML1–Runxl to CopineVIII, a novel member of the copine family, in an aggressive acute myelogenous leukemia with t(12;21) translocation. Leukemia. 2003;17:1665–1666
  16. Miller AD, Rosman GJ. Improved retroviral vectors for gene transfer and expression. Biotechniques. 1989;7:980–989
  17. Robertson KA, Hill DP, Kelley MR, Tritt R, Crum B, Van Epps S, et al.  The myeloid zinc finger gene (MZF-l) delays retinoic acid-induced apoptosis and differentiation in myeloid leukemia cells. Leukemia. 1998;12(5):690–698
  18. Xu D, Yoder M, Sutton J, Hromas R. Forced expression of Genesis, a winged helix transcriptional repressor isolated from embryonic stem cells, blocks granulocytic differentiation of 32D myeloid cells. Leukemia. 1998;12(2):207–212
  19. Saunders MJ, Tobal K, Yin JA. Detection of t(8;21) by reverse transcriptase polymerase chain reaction in patients in remission of acute myeloid leukemia type M2 after chemotherapy or bone marrow transplantation. Leuk. Res. 1994;18:891–895
  20. Kusec R, Laczika K, Knobl P, Friedl J, Greinix H, Kahls P, et al.  AML1–ETO fusion mRNA can be detected in remission blood samples of all patients with t(8;21) acute myeloid leukemia after chemotherapy or autologous bone marrow transplantation. Leukemia. 1994;8:735–739
  21. Guerrasio A, Rosso C, Martinelli G, Lo Coco F, Pampinella M, Santoro A, et al.  Polyclonal haemopoieses associated with long-term persistence of the AML1–ETO transcript in patients with FAB M2 acute myeloid leukemia in continous clinical remission. Br. J. Haematol. 1995;90:364–368
  22. Nucifora G, Larson RA, Rowley JD. Persistence of the t(8;21) translocation in patients with acute myeloid leukemia M2 in long term remissions. Blood. 1993;82:712–715
  23. Rhoades KL, Hetherington CJ, Harakawa N, Yergeau DA, Zhou L, Liu LQ, et al.  Analysis of the role of AML1–ETO in leukemogenesis, using an inducible transgenic mouse model. Blood. 2000;96:2108–2115
  24. Okuda T, Cai Z, Yang S, Lenny N, Lyu CJ, van Deursen JM, et al.  Expression of a knocked-in AML1–ETO leukemia gene inhibits the establishment of normal definitive hematopoiesis and directly generates dysplastic hematopoietic progenitors. Blood. 1998;91:3134–3143
  25. Kelly LM, Gilliland DG. Genetics of myeloid leukemias. Annu. Rev. Genomics Hum. Genet. 2002;3:179–198

PII: S0145-2126(03)00421-1

doi: 10.1016/j.leukres.2003.12.011

Leukemia Research
Volume 28, Issue 8 , Pages 863-868 , August 2004

Article Tools

* Image Usage & Resolution