Leukemia Research
Volume 28, Issue 8 , Pages 777-783 , August 2004

Bone marrow mast cell immunophenotyping in adults with mast cell disease: a prospective study of 33 patients

  • A Pardanani

      Affiliations

    • Divisions of Hematology and Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    • ,
  • T Kimlinger

      Affiliations

    • Divisions of Hematopathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    • ,
  • T Reeder

      Affiliations

    • Divisions of Hematology and Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    • ,
  • C.-Y Li

      Affiliations

    • Divisions of Hematopathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    • ,
  • A Tefferi

      Affiliations

    • Divisions of Hematology and Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-507-284-3159/3335; fax: +1-507-266-4972.

Received 3 July 2003 ,Accepted 2 October 2003.

References 

  1. Yavuz AS, Lipsky PE, Yavuz S, Metcalfe DD, Akin C. Evidence for the involvement of a hematopoietic progenitor cell in systemic mastocytosis from single-cell analysis of mutations in the c-kit gene. Blood. 2002;100:661–665
  2. Travis WD, Li C-Y, Yam LT, Bergstralh EJ, Swee RG. Significance of systemic mast cell disease with associated hematologic disorders. Cancer. 1988;62:965–972
  3. Valent P, Horny HP, Escribano L, Longley BJ, Li C-Y, Schwartz LB, et al.  Diagnostic criteria and classification of mastocytosis: a consensus proposal. Leuk. Res. 2001;25:603–625
  4. Nagata H, Worobec AS, Oh CK, Chowdhury BA, Tannenbaum S, Suzuki Y, et al.  Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder. Proc. Natl. Acad. Sci. U.S.A. 1995;92:10560–10564
  5. Escribano L, Orfao A, Villarrubia J, Diaz-Agustin B, Cervero C, Rios A, et al.  Immunophenotypic characterization of human bone marrow mast cells. A flow cytometric study of normal and pathological bone marrow samples. Anal. Cell Pathol. 1998;16:151–159
  6. Escribano L, Orfao A, Diaz-Agustin B, Villarrubia J, Cervero C, Lopez A, et al.  Indolent systemic mast cell disease in adults: immunophenotypic characterization of bone marrow mast cells and its diagnostic implications. Blood. 1998;91:2731–2736
  7. Schernthaner GH, Jordan JH, Ghannadan M, Agis H, Bevec D, Nunez R, et al.  Expression, epitope analysis, and functional role of the LFA-2 antigen detectable on neoplastic mast cells. Blood. 2001;98:3784–3792
  8. Escribano L, Orfao A, Villarrubia J, Martin F, Madruga JI, Cuevas M, et al.  Sequential immunophenotypic analysis of mast cells in a case of systemic mast cell disease evolving to a mast cell leukemia. Cytometry. 1997;30:98–102
  9. Jost E, Michaux L, Vanden Abeele M, Boland B, Latinne D, Godfraind C, et al.  Complex karyotype and absence of mutation in the c-kit receptor in aggressive mastocytosis presenting with pelvic osteolysis, eosinophilia and brain damage. Ann. Hematol. 2001;80:302–307
  10. Escribano L, Perez de Oteyza J, Nunez R, Orfao A. Cladribine induces immunophenotypical changes in bone marrow mast cells from mastocytosis. Report of a case of mastocytosis associated with a lymphoplasmacytic lymphoma. Leuk. Res. 2002;26:1043–1046
  11. Pardanani A, Kimlinger TK, Reeder TL, Li C-Y, Tefferi A. Differential expression of CD2 on neoplastic mast cells in patients with systemic mast cell disease with and without an associated clonal haematological disorder. Br. J. Haematol. 2003;120:691–694
  12. Pardanani A, Reeder TL, Kimlinger TK, Baek JY, Li C-Y, Butterfield JH, et al.  Flt-3 and c-kit mutations studies in a spectrum of chronic myeloid disorders including systemic mast cell disease. Leuk. Res. 2003;27:739–742
  13. Escribano L, Orfao A, Diaz-Agustin B, Cervero C, Herrero S, Villarrubia J, et al.  Human bone marrow mast cells from indolent systemic mast cell disease constitutively express increased amounts of the CD63 protein on their surface. Cytometry. 1998;34:223–228
  14. Escribano L, Diaz-Agustin B, Bravo P, Navalon R, Almeida J, Orfao A. Immunophenotype of bone marrow mast cells in indolent systemic mast cell disease in adults. Leuk. Lymphoma. 1999;35:227–235
  15. Butterfield JH, Weiler D, Dewald G, Gleich GJ. Establishment of an immature mast cell line from a patient with mast cell leukemia. Leuk. Res. 1988;12:345–355
  16. Valent P, Bevec D, Maurer D, Besemer J, Di Padova F, Butterfield JH, et al.  Interleukin 4 promotes expression of mast cell ICAM-1 antigen. Proceedings of the National Academy of Sciences of the United States of America. 1991;88:3339–3342
  17. Valent P, Bettelheim P. Cell surface structures on human basophils and mast cells: biochemical and functional characterization. Adv. Immunol. 1992;52:333–423
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PII: S0145-2126(03)00416-8

doi: 10.1016/j.leukres.2003.10.035

Leukemia Research
Volume 28, Issue 8 , Pages 777-783 , August 2004

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