Leukemia Research
Volume 28, Issue 3 , Pages 267-273 , March 2004

T cell receptor gamma (TCRG) gene rearrangements in Brazilian children with acute lymphoblastic leukemia: analysis and implications for the study of minimal residual disease

  • Carlos A Scrideli

      Affiliations

    • Department of Pediatrics, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Av. Bandeirantes, 3900, 14049-900-Ribeirão Preto, SP, Brazil
    • ,
  • Rosane G.P Queiróz

      Affiliations

    • Department of Pediatrics, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Av. Bandeirantes, 3900, 14049-900-Ribeirão Preto, SP, Brazil
    • ,
  • Simone Kashima

      Affiliations

    • Ribeirão Preto Hemocentro Foundation, Ribeirão Preto, SP, Brazil
    • ,
  • Bianca O.M Sankarankutty

      Affiliations

    • Department of Pediatrics, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Av. Bandeirantes, 3900, 14049-900-Ribeirão Preto, SP, Brazil
    • ,
  • Luiz G Tone

      Affiliations

    • Department of Pediatrics, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Av. Bandeirantes, 3900, 14049-900-Ribeirão Preto, SP, Brazil
    • Corresponding Author InformationCorresponding author. Tel.: +55-16-602-2573; fax: +55-16-602-2700.

Received 24 March 2003 ,Accepted 29 July 2003.

References 

  1. Van Dongen JJM, Wolvers-Tettero ILM. Analysis of immunoglobulin and T cell receptor genes. Part I. Basic and technical aspects. Clin. Chim. Acta. 1991;198:1–92
  2. Van Dongen JJM, Langerak AW. Immunoglobulin and T-cell receptor rearrangements. In: Pui CH, editor. Childhood leukemias. Cambridge: Cambridge University Press; 1999. p. 145–67.
  3. Szczepanski T, Langerak AW, Willemse MJ, Wolvers-Tettero ILM, van Wering ER, van Dongem JJM. T cell receptor gamma (TCRG) gene rearrangements in T-cell acute lymphoblastic leukemia reflect ‘end-stage’ recombinations: implications for minimal residual disease monitoring. Leukemia. 2000;14:1208–1214
  4. Szczenpanski T, Beishuizen A, Pongers-Willemse MJ, Hahlen K, Van Wering ER, Wijkhuijs AJM, et al.  Cross-lineage T cell receptor gene rearrangements in more than ninety percent of childhood precursor-B acute lymphoblastic leukemias: alternative PCR targets for detection of minimal residual disease. Leukemia. 1999;13:196–205
  5. Brumpt C, Delabesse E, Beldjord K, Davi F, Cayuela JM, Millien C, et al.  The incidence of clonal T-cell receptor rearrangements in B-cell precursor acute lymphoblastic leukemia varies with age and genotype. Blood. 2000;96:2254–2261
  6. Goulden NJ, Knechtli CJS, Garland RJ, Langlands K, Hancock JP, Potter MN, et al.  Minimal residual disease analysis for the prediction of relapse in children with standard-risk acute lymphoblastic leukemia. Br. J. Haematol. 1998;100:235–244
  7. Gruhn B, Hongeng S, Yi H, Hancock ML, Rubnitz JE, Neale GAM, et al.  Minimal residual disease after intensive induction therapy in childhood acute lymphoblastic leukemia predicts outcome. Leukemia. 1998;12:675–681
  8. Cavé H, Ten Bosch JW, Suciu S, Guidal C, Waterkeyn C, Otten J, et al.  Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia. N. Engl. J. Med. 1998;339:591–598
  9. Van Dongen JJM, Seriu T, Panzer-Grumayer ER, Biondi A, Pongers-Willemse MJ, Corral L, et al.  Prognostic value of minimal residual disease in acute lymphoblastic leukemia in childhood. Lancet. 1998;352:1731–1738
  10. Biondi A, Valsecchi MG, Seriu T, D’Aniello E, Wilemse MJ, Fashing K, et al.  Molecular detection of minimal residual disease is a strong predictive factor of relapse in childhood B-lineage acute lymphoblastic leukemia with medium risk features. A case control study of the International BFM study group. Leukemia. 2000;14:1939–1943
  11. Scrideli CA, Kashima S, Cipolotti R, Defavery R, Bernardes JE, Tone LG. Minimal residual disease in Brazilian children with acute lymphoid leukemia: comparison of three detection methods by PCR. Leuk. Res. 2002;26:431–438
  12. Quertermous T, Murre C, Dialynas D, Duby AD, Strominger JL, Waldman TA, et al.  Human T-cell γ chain genes: organization, diversity and rearrangement. Science. 1986;231:252–255
  13. Greenberg JM, Quertermous T, Seidman JG, Kersey JH. Human T cell γ-chain gene rearrangements in acute lymphoid and non lymphoid leukemias: comparison with the T cell receptor β-chain gene. J. Immunol. 1986;137:2043–2049
  14. Huck S, Dariavach P, Lefranc MP. Variable region genes in the human T-cell rearranging gamma (TRG) locus: V-J junction and homology with the mouse genes. EMBO J. 1988;7:719–726
  15. Lefranc MP, Forster A, Baer R, Stinson MA, Rabbitts TH. Diversity and rearrangement of the human T cell rearranging γ genes: nine germ-line variable genes belonging to two subgroups. Cell. 1986;45:237–246
  16. Taylor JJ, Rowe D, Williamson IK, Christmas SE, Proctor SJ, Middleton PG. Detection of T-cell receptor γ chain V gene rearrangements using the polymerase chain reaction: application to the study of the clonal disease cells in acute lymphoblastic leukemia. Blood. 1991;9:1989–1995
  17. Foroni L, Harrison C, Hoffbrand AC, Potter MN. Investigation of minimal residual disease in childhood and adult acute lymphoblastic leukemia by molecular analysis. Br. J. Haematol. 1999;105:7–24
  18. Pongers-Willemse MJ, Seriu T, Stolz F, D’Aniello E, Gameiro P, Pisa P, et al.  Primers and protocols for standardized detection of minimal residual disease in acute lymphoblastic leukemia using immunoglobulin and T cell receptor gene rearrangements and TAL1 deletions as PCR targets. Report of the BIOMED-1 CONCERTED ACTION: investigation of minimal residual disease in acute leukemia. Leukemia. 1999;13:110–118
  19. Bennett J, Catovski D, Daniel MT, Frandrin G, Galton DA, Gralnick HR, et al.  French-American-British (FAB) Cooperative Group proposals for the classification of acute leukemias. Br. J. Haematol. 1976;3:451–458
  20. Brandalise S, Odone V, Pereira W, Andrea M, Zanichelli M, Aranega V. Treatment results of three consecutive Brazilian cooperative childhood ALL protocols: GBTLI-80, GBTLI-82 and GBTLI-85. ALL Brazilian Group. Leukemia. 1993;7(Suppl 2:S):142–145
  21. Catovsky D, Matutes E, Buccheri V, Shetty V, Hanslip J, Yoshida N, et al.  A classification of acute leukaemia for the 1990s. Ann. Hematol. 1991;62:16–21
  22. Langerak AW, Szczepanski T, van der Burg M, Wolvers-Tettero IL, van Dongen JJ. Heteroduplex PCR analysis of rearranged T cell receptor genes for clonality assessment in suspect T cell proliferations. Leukemia. 1997;11:2192–2199
  23. Kwok S, Higushi R. Avoiding false positives with PCR. Nature. 1988;339:239–240
  24. Scrideli CA, Simões AL, Defavery R, Bernardes JE, Duarte MHO, Tone LG. Childhood B-lineage acute lymphoblastic leukemia clonality study by the polymerase chain reaction. J. Pediatr. Hematol./Oncol. 1997;19:516–522
  25. Campana D, Pui CH. Detection of minimal residual disease in acute leukemia: methodological advances and clinical significance. Blood. 1995;85:1416–1434
  26. Brisco MJ, Condon J, Hughes E, Neoh SH, Sykes PJ, Seshadri R, et al.  Outcome prediction in childhood acute lymphoblastic leukemia by molecular quantification of residual disease at end of induction. Lancet. 1994;343:196–200
  27. Jacquy C, Delepaut B, Van Daele S, Vaerman JL, Zeneberg A, Brichard B, et al.  A prospective study of minimal residual disease in childhood B-lineage acute lymphoblastic leukemia: MRD level at the end of induction is a strong predictive factor of relapse. Br. J. Haematol. 1997;98:140–146
  28. Roberts WM, Estrov Z, Ouspenskaia MV, Johnston DA, McClain KL, Zipf TL. Measurements of residual leukemia during remission in childhood acute lymphoblastic leukemia. N. Engl. J. Med. 1997;336:317–323
  29. Scrideli CA, Defavery R, Bernardes JE, Tone LG. Prognostic significance of bi/oligoclonality in childhood acute lymphoblastic leukemia as determined by polymerase chain reaction. Sao Paulo Med. J. 2001;119:175–180
  30. Scrideli CA, Kashima S, Cipolloti R, Defavery R, Tone LG. Clonal evolution as the limiting factor in the detection of minimal residual disease by polymerase chain reaction in children in Brazil with acute lymphoid leukemia. J. Pediatr. Hematol./Oncol. 2002;24:364–367
  31. Boehm TLJ, Werle A, Ganser A, Kornhuber B, Drahovsky D. T cell receptor γ chain variable gene rearrangements in acute lymphoblastic leukemias of T and B lineage. Eur. J. Immunol. 1987;17:1593–1597
  32. Chen Z, Font MP, Loiseau P, Bories JC, Degos L, Lefranc MP, et al.  The human T-cell Vγ gene locus: cloning of new segments and study of Vγ rearrangements in neoplastic T and B cells. Blood. 1998;72:776–783
  33. Hara J, Benedict SH, Yumura K, Ha-Kawa K, Gelfand EW. Rearrangement of variable region T cell receptor γ genes in acute lymphoblastic leukemia. Vγ gene usage differs in mature and immature T cells. J. Clin. Invest. 1989;83:1277–1283
  34. Gonzalez-Sarmiento R, Greenberg JM, Kersey JH. Usage of γ chain variable regions in human acute lymphoblastic leukemias. Blood. 1988;72:2038–2041
  35. Beishuizen A, Verhoeven MAJ, van Wering ER, Hahlen K, Hooijkaas H, Van Dongen JJM. Analysis of Ig and T-cell receptor genes in 40 childhood acute lymphoblastic leukemias at diagnosis and subsequent relapse: implications for the detection of minimal residual disease by polymerase chain reaction analysis. Blood. 1994;83:2238–2247
  36. Cavè H, Guidal C, Rohrlich P, Delfau MH, Broyart A, Lescouer B, et al.  Prospective monitoring and quantification of residual blasts in childhood acute lymphoblastic leukemia by polymerase chain reaction study of δ and γ T-cell receptor genes. Blood. 1994;83:1892–1902
  37. Peham M, Panzer S, Fasching K, Haas OA, Fischer S, Marschalek R, et al.  Low frequency of clonotypic Ig and T-cell receptor gene rearrangements in t(4;11) infant acute lymphoblastic leukaemia and its implication for the detection of minimal residual disease. Br. J. Haematol. 2002;117:315–321
  38. Trainor KJ, Brisco MJ, Wan JH, Neoh S, Grist S, Morley AA. Gene rearrangement in B- and T-lymphoproliferative disease detected by the polymerase chain reaction. Blood. 1991;78:192–196
  39. Januszkieewicz DA, Nowak JS. Detection of clonality by polymerase chain reaction in childhood B-lineage acute lymphoblastic leukemia. Ann. Hematol. 1994;69:107–110
  40. Sykes PJ, Snell LE, Brisco MJ, Neoh SH, Hughes E, Dolman G, et al.  The use of monoclonal gene rearrangement for detection of minimal residual disease in acute lymphoblastic leukemia of childhood. Leukemia. 1997;11:153–158
  41. Kneba M, Bolz I, Linke B, Bertram J, Rothaupt D, Hiddemann W. Characterization of clone-specific rearranged T-cell receptor γ-chain genes in lymphomas and leukemias by the polymerase chain reaction and DNA sequencing. Blood. 1994;84:574–581
  42. van der Velden VH, Wijkhuijs JM, Jacobs DC, van Wering ER, van Dongen JJ. T cell receptor gamma gene rearrangements as targets for detection of minimal residual disease in acute lymphoblastic leukemia by real-time quantitative PCR analysis. Leukemia. 2002;16:1372–1380
  43. Nirmala K, Rajalekshmy KR, Raman SG, Shanta V, Rajkumar T. PCR-heteroduplex analysis of TCR gamma, delta and TAL-1 deletions in T-acute lymphoblastic leukemias: implications in the detection of minimal residual disease. Leuk. Res. 2002;26:335–343
  44. Sazawal S, Bhatia K, Gurbuxani S, Singh Arya L, Raina V, Khattar A, et al.  Pattern of immunoglobulin (Ig) and T-cell receptor (TCR) gene rearrangements in childhood acute lymphoblastic leukemia in India. Leuk. Res. 2000;24:575–582
  45. Langerak AW, Wolvers-Tettero ILM, van den Beemd MWM, Ludwig WD, Hahlen K, Necker A, et al.  Immunophenotypic and immunogenotypic characteristics of TCRγδ+ T cell acute lymphoblastic leukemia. Leukemia. 1999;13:206–214

PII: S0145-2126(03)00266-2

doi: 10.1016/j.leukres.2003.07.001

Leukemia Research
Volume 28, Issue 3 , Pages 267-273 , March 2004

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