Leukemia Research
Volume 28, Issue 3 , Pages 295-299 , March 2004

An in vivo propagated human acute myeloid leukemia expressing ABCA3

  • Kevin Norwood

      Affiliations

    • Center for Cell and Gene Therapy, Baylor College of Medicine, N1030 One Baylor Plaza, Houston, TX 77030, USA
    • ,
  • Rui-Yu Wang

      Affiliations

    • Molecular Hematology Therapy, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    • ,
  • Charlotte Hirschmann-Jax

      Affiliations

    • Center for Cell and Gene Therapy, Baylor College of Medicine, N1030 One Baylor Plaza, Houston, TX 77030, USA
    • ,
  • Michael Andreeff

      Affiliations

    • Molecular Hematology Therapy, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    • ,
  • Malcolm K Brenner

      Affiliations

    • Center for Cell and Gene Therapy, Baylor College of Medicine, N1030 One Baylor Plaza, Houston, TX 77030, USA
    • ,
  • Margaret A Goodell

      Affiliations

    • Center for Cell and Gene Therapy, Baylor College of Medicine, N1030 One Baylor Plaza, Houston, TX 77030, USA
    • ,
  • Gerald G Wulf

      Affiliations

    • Department of Hematology and Oncology, University of Goettingen, Rober-Koch-Strasse 40, 37075 Goettingen, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49-551-3912881; fax: +49-551-392914.

Received 25 May 2003 ,Accepted 1 August 2003.

References 

  1. Fialkow PJ, Singer JW, Adamson JW, Vaidya K, Dow LW, Ochs J, et al.  Acute nonlymphocytic leukemia: heterogeneity of stem cell origin. Blood. 1981;57:1068–1073
  2. Keinanen M, Griffin JD, Bloomfield CD, Machnicki J, de la Chapelle A. Clonal chromosomal abnormalities showing multiple-cell-lineage involvement in acute myeloid leukemia. New Engl. J. Med. 1988;318:1153–1158
  3. Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 1997;3:730–737
  4. Wulf GG, Wang RY, Kuehnle I, Weidner D, Marini F, Brenner MK, et al.  A leukemic stem cell with intrinsic drug efflux capacity in acute myeloid leukemia. Blood. 2001;98:1166–1173
  5. Terpstra W, Prins A, Ploemacher RE, Wognum BW, Wagemaker G, Lowenberg B, et al.  Long-term leukemia-initiating capacity of a CD34-subpopulation of acute myeloid leukemia. Blood. 1996;87:2187–2194
  6. Blair A, Hogge DE, Sutherland HJ. Most acute myeloid leukemia progenitor cells with long-term proliferative ability in vitro and in vivo have the phenotype CD34(+)/CD71(−)/HLA-DR. Blood. 1998;92:4325–4335
  7. Ailles LE, Gerhard B, Kawagoe H, Hogge DE. Growth characteristics of acute myelogenous leukemia progenitors that initiate malignant hematopoiesis in nonobese diabetic/severe combined immunodeficient mice. Blood. 1999;94:1761–1772
  8. Dick JE. Human stem cell assays in immune-deficient mice. Curr. Opin. Hematol. 1996;3:405–409
  9. Beran M, Pisa P, Kantarjian H, Porwit A, Bjorkholm M. Growth of sensitive and drug-resistant human myeloid leukemia cells in SCID mice. Hematol. Pathol. 1994;8:135–154
  10. Nishi N, Ishikawa R, Inoue H, Nishikawa M, Yoneya T, Kakeda M, et al.  In vitro long-term culture of human primitive hematopoietic cells supported by murine stromal cell line MS-5. Leukemia. 1997;11(Suppl 3):468–473
  11. Goodell MA, Brose K, Paradis G, Conner AS, Mulligan RC. Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J. Exp. Med. 1996;183:1797–1806
  12. Engel H, Drach J, Keyhani A, Jiang S, Van NT, Kimmel M, et al.  Quantitation of minimal residual disease in acute myelogenous leukemia and myelodysplastic syndromes in complete remission by molecular cytogenetics of progenitor cells. Leukemia. 1999;13:568–577
  13. Errecalde AL, Garcia AL, Inda AM, Badran AF. G2 restriction point within populations of hepatocytes and tongue keratinocytes in young, growing mice. Cell Biol. Int. 1998;22:359–362
  14. Seabright M. A rapid banding technique for human chromosomes. Lancet. 1971;2:971–972
  15. Boutonnat J, Bonnefoix T, Mousseau M, Seigneurin D, Ronot X. Coexpression of multidrug resistance involve proteins: a flow cytometric analysis. Anticancer Res. 1998;18:2993–2999
  16. Nicolson GL. Generation of phenotypic diversity and progression in metastatic tumor cells. Cancer Metastasis Rev. 1984;3:25–42
  17. Bunting KD, Galipeau J, Topham D, Benaim E, Sorrentino BP. Effects of retroviral-mediated MDR1 expression on hematopoietic stem cell self-renewal and differentiation in culture. Ann. N.Y. Acad. Sci. 1999;872:125–140 [discussion 140-121]
  18. Zhou S, Schuetz JD, Bunting KD, Colapietro AM, Sampath J, Morris JJ, et al.  The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Nat. Med. 2001;7:1028–1034
  19. Leith CP, Kopecky KJ, Chen IM, Eijdems L, Slovak ML, McConnell TS, et al.  Frequency and clinical significance of the expression of the multidrug resistance proteins MDR1/P-glycoprotein, MRP1, and LRP in acute myeloid leukemia: a Southwest Oncology Group Study. Blood. 1999;94:1086–1099
  20. Ross DD, Karp JE, Chen TT, Doyle LA. Expression of breast cancer resistance protein in blast cells from patients with acute leukemia. Blood. 2000;96:365–368
  21. Connors TD, Van Raay TJ, Petry LR, Klinger KW, Landes GM, Burn TC. The cloning of a human ABC gene (ABCA3) mapping to chromosome 16p13.3. Genomics. 1997;39:231–234
  22. Klugbauer N, Hofmann F. Primary structure of a novel ABC transporter with a chromosomal localization on the band encoding the multidrug resistance-associated protein. FEBS Lett. 1996;391:61–65
  23. Broccardo C, Luciani M, Chimini G. The ABCA subclass of mammalian transporters. Biochim. Biophys. Acta. 1999;1461:395–404

PII: S0145-2126(03)00265-0

doi: 10.1016/j.leukres.2003.08.006

Leukemia Research
Volume 28, Issue 3 , Pages 295-299 , March 2004

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