Leukemia Research
Volume 28, Issue 3 , Pages 285-294 , March 2004

Elevated expression of a subset of interferon inducible genes in primary bone marrow cells expressing p185 Bcr-Abl versus p210 Bcr-Abl by DNA microarray analysis

  • Anjali S Advani

      Affiliations

    • Division of Hematology and Oncology, Duke University Medical Center, Durham, NC 27710, USA
    • Present address: Department of Hematology and Medical Oncology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk R35, Cleveland, OH 44195, USA.
    • ,
  • Holly K Dressman

      Affiliations

    • Department of Genetics, Duke University Medical Center, Durham, NC 27710, USA
    • ,
  • Marisol Quiroz

      Affiliations

    • Department of Pharmacology and Cancer Biology, Duke University Medical Center, Box 3813, Durham, NC 27710, USA
    • ,
  • Gregory A Taylor

      Affiliations

    • Department of Medicine and Immunology, Division of Geriatrics, and Center for the Study of Aging and Development, Duke University and VA Medical Center, Durham, NC 27710, USA
    • ,
  • Ann Marie Pendergast

      Affiliations

    • Department of Pharmacology and Cancer Biology, Duke University Medical Center, Box 3813, Durham, NC 27710, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-919-681-8086; fax: +1-919-681-7148.

Received 3 January 2003 ,Accepted 22 July 2003.

References 

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  2. Pendergast AM. BCR/ABL protein domain function and signaling. In: Chronic myeloid leukaemia: biology and treatment. London: Martin Dunitz; 2001. p. 19–39.
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  5. Li S, Ilaria RL, Million RP, Daley GQ, van Etten RA. The p190, p210, and p230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity. J. Exp. Med. 1999;189:1399
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  14. Taylor GA, Studder R, Rulong S, Hudson E, Pei V, Pavlakis GN, et al.  The inducibly expressed GTPase (IGTP) localizes to the endoplasmic reticulum independent of GTP binding. J. Biol. Chem. 1997;272:10639
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☆ Author responses: contributions of each author: Anjali Advani—senior author, formulated/conducted/analyzed experiments, wrote manuscript; Holly Dressman—analyzed microarray data, performed statistical analyses; Marisol Quiroz—prepared bone marrow mononuclear cells for experiments; Gregory Taylor—supplied antibodies for interferon-γ-inducible GTPases, supplied background on the function/structure of the interferon-inducible GTPases; Ann Marie Pendergast—principal investigator’s lab, formulated initial experimental idea/plan, supplied reagents for all experiments, critically reviewed experiments and manuscript.

PII: S0145-2126(03)00264-9

doi: 10.1016/S0145-2126(03)00264-9

Leukemia Research
Volume 28, Issue 3 , Pages 285-294 , March 2004

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