Leukemia Research
Volume 27, Issue 9 , Pages 865-867 , September 2003

2-Deoxycoformycin in the treatment of T-large granular lymphocyte leukemia

  • Panagiotis Tsirigotis

      Affiliations

    • Third Department of Internal Medicine, First Hospital of Athens, Social Insurance Foundation, Zaimi Street-Melissia, 15127 Athens, Greece
    • Corresponding Author InformationCorresponding author. Tel.: +30-1-8042320; fax: +30-1-8041837.
    • ,
  • Evangelos Venetis

      Affiliations

    • Third Department of Internal Medicine, First Hospital of Athens, Social Insurance Foundation, Zaimi Street-Melissia, 15127 Athens, Greece
    • ,
  • Violeta Kapsimali

      Affiliations

    • Immunology-Histocompatibility Department, Evangelismos Hospital, Athens, Greece
    • ,
  • Dimitra Rontogianni

      Affiliations

    • Histopathology Department, Evangelismos Hospital, Athens, Greece
    • ,
  • Ephrosini Varvitsioti

      Affiliations

    • Third Department of Internal Medicine, First Hospital of Athens, Social Insurance Foundation, Zaimi Street-Melissia, 15127 Athens, Greece
    • ,
  • Vasiliki Pappa

      Affiliations

    • Second Department of Internal Medicine, Evangelismos Hospital, Athens, Greece
    • ,
  • Panos Apostolidis

      Affiliations

    • Third Department of Internal Medicine, First Hospital of Athens, Social Insurance Foundation, Zaimi Street-Melissia, 15127 Athens, Greece

Received 14 October 2002 ,Accepted 10 January 2003.

References 

  1. McKenna RW, Parkin J, Kersey JH, Gajl-Peczalska KJ, Peterson L, Brunning RD. Chronic lymphoproliferative disorder with unusual clinical, morphologic, ultrastructural and membrane surface marker characteristics. Am. J. Med. 1977;62:588
  2. Loughran TP. Clonal diseases of large granular lymphocytes. Blood. 1993;82:1–14
  3. Dhodapkar MV, Li CY, Lust JA, Tefferi A, Phyliky RL. Clinical spectrum of clonal proliferations of T-large granular lymphocytes: a T-cell clonopathy of undetermined significance. Blood. 1994;84:1620–1627
  4. Loughran TP, Kidd PG, Starkebaum G. Treatment of large granular lymphocyte leukemia with oral low-dose methotrexate. Blood. 1994;84:2164–2170
  5. Langerak AW, Van Den Beemd R, Wolvers-Tettero ILM, Boor PPC, Van Lochem EG, Hooijkaas H, et al.  Molecular and flow cytometric analysis of the Vβ repertoire for clonality assessment in mature TCRαβ T-cell proliferations. Blood. 2001;98:165–173
  6. Harris NL, Jaffe ES, Stein H, Banks PM, Chan JK, Cleary ML, et al.  A revised European–American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood. 1994;84:1361
  7. Gentile TC, Uner AH, Hutchison RE, Wright J, Ben Ezra J, Russell EC, et al.  CD3+, CD56+ aggressive variant of large granular lymphocyte leukemia. Blood. 1994;84:2315–2321
  8. Gentile TC, Wener MH, Starkebaum G, Loughran TP. Humoral immune abnormalities in T-cell large granular lymphocyte leukemia. Leuk. Lymph. 1996;23:365–370
  9. Liu JH, Wei S, Lamy T, Epling-Burnette PK, Starkebaum G, Djeu JY, et al.  Chronic neutropenia mediated by Fas ligand. Blood. 2000;95:3119–3222
  10. Loughran TP, Starkebaum G, Clark E, Wallace P, Kadin ME. Evaluation of splenectomy in large granular lymphocyte leukemia. Br. J. Haematol. 1987;67:135
  11. Gonzales-Chambers R, Rosenfeld C, Winkelstein A, Dameshek L. Eosinophilia resulting from administration of recombinant granulocyte-macrophage colony-stimulating factor in a patient with Tγ-lymphoproliferative disease. Am. J. Hematol. 1991;36:157
  12. Gabor P, Mishalani S, Lee S. Rapid response to cyclosporine therapy and sustained remission in large granular lymphocyte leukemia. Blood. 1996;87:1199
  13. Montserrat R, Cervantes F, Beltran JM, Zuazu F, Nieto LH, Rayon C, et al.  Deoxycomformycin in the treatment of patients with hairy cell leukemia. Cancer. 2000;88:352–357
  14. Grever MR, Siaw MFE, Jacob WF, et al.  The biochemical and clinical consequences of 2-deoxycomformycin in refractory lymphoproliferative malignancy. Blood. 1981;57:406–417
  15. Giblett ER, Anderson JE, Cohen F, Pollara B, Meuwissen HJ. Adenosine–deaminase deficiency in two patients with severely impaired cellular immunity. Lancet. 1972;2:1067–1069
  16. Kurzrock R, Pilat S, Duvic M. Pentostatin therapy of T-cell lymphomas with cutaneous manifestations. J. Clin. Oncol. 1999;17:3117–3121

PII: S0145-2126(03)00019-5

doi: 10.1016/S0145-2126(03)00019-5

Leukemia Research
Volume 27, Issue 9 , Pages 865-867 , September 2003

Article Tools