Leukemia Research
Volume 27, Issue 6 , Pages 467-469, June 2003

The role of Epstein-Barr virus and elevated levels of tumor necrosis factor in determining prognosis in Asian peripheral T-cell lymphomas

Department of Medicine, New York Medical College, Our Lady of Mercy Cancer Center, 600 East 233rd Street, Bronx, NY 10466, USA

Received 29 October 2002; accepted 29 October 2002.

Abstract 

Evidence of Epstein-Barr virus (EBV) infection in patients continues to be associated with the development of various lymphomas, and EBV genomic regions are detected in some lymphoma cells. Its role in causality and progression of disease versus the role of a passenger continues to be debated. Several reports of Asian T-cell lymphomas have also associated these diseases with evidence of EBV infections. Asian T-cell lymphomas are clinically distinct from Western T-cell lymphoma, and are also associated with increased levels of cytokine production, including tumor necrosis factor (TNF). The current study reports correlations of EBV + T-cell lymphoma with higher levels of TNF, and suggests some prognostic correlations.

Keywords: Epstein-Barr virus, T-cell lymphomas, Tumor necrosis factor

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0145-2126(02)00274-6

doi:10.1016/S0145-2126(02)00274-6

Leukemia Research
Volume 27, Issue 6 , Pages 467-469, June 2003

Article Tools