Leukemia Research
Volume 27, Issue 6 , Pages 489-491, June 2003

ABO incompatibility between donor and recipient and clinical outcomes in allogeneic stem cell transplantation

  • James Goldman

      Affiliations

    • Department of Pathology and Laboratory Medicine (Transfusion Medicine Unit), University of Rochester Medical Center, Box 608, 60 Elmwood Avenue, Rochester, NY 14642, USA
    • ,
  • Jane Liesveld

      Affiliations

    • Department of Medicine (Hematology–Oncology Unit), University of Rochester Medical Center, Rochester, NY 14642, USA
    • ,
  • Diane Nichols

      Affiliations

    • Department of Medicine (Hematology–Oncology Unit), University of Rochester Medical Center, Rochester, NY 14642, USA
    • ,
  • Joanna Heal

      Affiliations

    • Department of Medicine (Hematology–Oncology Unit), University of Rochester Medical Center, Rochester, NY 14642, USA
    • ,
  • Neil Blumberg

      Affiliations

    • Department of Pathology and Laboratory Medicine (Transfusion Medicine Unit), University of Rochester Medical Center, Box 608, 60 Elmwood Avenue, Rochester, NY 14642, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-585-275-9656; fax: +1-585-273-3002.

Received 27 June 2002; accepted 4 October 2002.

Abstract 

We performed a retrospective, cohort study to evaluate the impact on recipient survival of ABO incompatibility between recipient and donor after allogeneic stem cell transplantation, primarily involving marrow-derived cells. No statistically significant difference was noted in survival for 153 patients with acute or chronic leukemia or myelodysplastic syndrome receiving ABO identical or ABO mismatched allografts. Five patients who had allografts that were bidirectionally incompatible (both donor cells and plasma incompatible) did have significantly poorer survival than the other recipients, similar to the experience reported in one other cohort study. However, these patients had other risks for mortality, including being older and receiving transplants from matched, unrelated donors. Our data do not support a significant role for ABO donor–recipient matching in allogeneic stem cell transplantation.

Keywords: ABO, Donor–recipient matching, Allogeneic stem cell transplantation

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PII: S0145-2126(02)00259-X

doi:10.1016/S0145-2126(02)00259-X

Leukemia Research
Volume 27, Issue 6 , Pages 489-491, June 2003

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