Leukemia Research
Volume 27, Issue 5 , Pages 405-411 , May 2003

A randomized study comparing interferon (IFNα) plus low-dose cytarabine and interferon plus hydroxyurea (HU) in early chronic-phase chronic myeloid leukemia (CML)

  • T. Kühr

      Affiliations

    • Department of Internal Medicine, General Hospital, Grieskirchnerstr. 42, Wels A-4600, Austria
    • Corresponding Author InformationCorresponding author. Tel.: +43-7242-415-9-3454.
  • ,
  • S. Burgstaller

      Affiliations

    • Department of Internal Medicine, General Hospital, Grieskirchnerstr. 42, Wels A-4600, Austria
  • ,
  • U. Apfelbeck

      Affiliations

    • Department of Internal Medicine, University Hospital, Graz, Austria
  • ,
  • W. Linkesch

      Affiliations

    • Department of Internal Medicine, University Hospital, Graz, Austria
  • ,
  • H. Seewann

      Affiliations

    • Department of Internal Medicine, General Hospital, Fürstenfeld, Austria
  • ,
  • M. Fridrik

      Affiliations

    • Department of Internal Medicine, General Hospital, Linz, Austria
  • ,
  • G. Michlmayr

      Affiliations

    • Department of Internal Medicine, Hospital of the Sisters of Mercy, Linz, Austria
  • ,
  • O. Krieger

      Affiliations

    • Department of Internal Medicine, Hospital of the Elizabethans, Linz, Austria
  • ,
  • D. Lutz

      Affiliations

    • Department of Internal Medicine, Hospital of the Elizabethans, Linz, Austria
  • ,
  • W. Lin

      Affiliations

    • Department of Internal Medicine, State Hospital, Villach, Austria
  • ,
  • J. Pont

      Affiliations

    • Department of Internal Medicine, Kaiser Franz Josef Hospital, Wien, Austria
  • ,
  • L. Köck

      Affiliations

    • Department of Internal Medicine, County Hospital, Lienz, Austria
  • ,
  • K. Abbrederis

      Affiliations

    • Department of Internal Medicine, Municipal Hospital, Dornbirn, Austria
  • ,
  • C. Baldinger

      Affiliations

    • Department of Internal Medicine, General Hospital, Grieskirchnerstr. 42, Wels A-4600, Austria
  • ,
  • R. Buder

      Affiliations

    • Department of Internal Medicine, Hospital of the Brothers of Mercy, Linz, Austria
  • ,
  • D. Geissler

      Affiliations

    • Department of Internal Medicine, State Hospital, Klagenfurt, Austria
  • ,
  • H. Hausmaninger

      Affiliations

    • Department of Internal Medicine, State Hospital, Salzburg, Austria
  • ,
  • A. Lang

      Affiliations

    • Department of Internal Medicine, State Hospital, Feldkirch, Austria
  • ,
  • A. Zabernigg

      Affiliations

    • Department of Internal Medicine, County Hospital, Kufstein, Austria
  • ,
  • C. Duba

      Affiliations

    • Department of Medical Biology and Human Genetics, University of Innsbruck, Innsbruck, Austria
  • ,
  • W. Hilbe

      Affiliations

    • Department of Internal Medicine, University Hospital Innsbruck, Innsbruck, Austria
  • ,
  • W. Eisterer

      Affiliations

    • Department of Internal Medicine, University Hospital Innsbruck, Innsbruck, Austria
  • ,
  • M. Fiegl

      Affiliations

    • Department of Internal Medicine, University Hospital Innsbruck, Innsbruck, Austria
  • ,
  • R. Greil

      Affiliations

    • Department of Internal Medicine, University Hospital Innsbruck, Innsbruck, Austria
  • ,
  • G. Gastl

      Affiliations

    • Department of Internal Medicine, University Hospital Innsbruck, Innsbruck, Austria
  • ,
  • J. Thaler

      Affiliations

    • Department of Internal Medicine, General Hospital, Grieskirchnerstr. 42, Wels A-4600, Austria
  • ,
  • for the Austrian CML Study Group

Received 13 September 2002 ,Accepted 28 September 2002.

References 

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  5. Chronic Myeloid Leukemia Trialists’ Collaborative Group. Interferon α versus chemotherapy for chronic myeloid leukemia: a meta-analysis of seven randomized trials. J Natl Cancer Inst 1997;89:1616–20.
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  10. Thaler J, Hilbe W for the Austrian CML Study Group. Comparative analysis of two consecutive phase II studies with interferon α and interferon α + araC in untreated chronic-phase CML patients. Bone Marrow Transplant 1996;17(Suppl 3):25–8.
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  13. Arthur CK, Ma DDF. Combined interferon α-2a and cytosine arabinoside as first-line treatment for chronic myeloid leukemia. Acta Heamatol. 1993;89(Suppl. 1):15–21
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  16. Giles FJ, Shan J, Chen S, Advani SH, Supandiman I, Aziz Z, et al.  A prospective randomized study of α-2b Interferon plus Hydroxyurea or Cytarabine for patients with early chronic phase chronic myelogenous leukemia: The International Oncology Study Group CML1 Study. Leukemia Lymphoma. 2000;37(3/4):367–377

PII: S0145-2126(02)00223-0

doi: 10.1016/S0145-2126(02)00223-0

Leukemia Research
Volume 27, Issue 5 , Pages 405-411 , May 2003