« Previous
Next »
Leukemia Research
Volume 27, Issue 5
, Pages 437-444
, May 2003
Preclinical evaluation of antineoplastic activity of inhibitors of DNA methylation (5-aza-2′-deoxycytidine) and histone deacetylation (trichostatin A, depsipeptide) in combination against myeloid leukemic cells
References
-
.
Different blocks in differentiation of myeloid leukemia cells.
Proc. Natl. Acad. Sci. U.S.A. 1974;71:3507–3511
- . Induction of differentiation of human acute myelogenous leukemia cells: therapeutic implications. Blood. 1983;62:709–721
- . Cancer epigenetics comes of age. Nat. Genet. 1999;21:163–167
- . DNA hypermethylation in tumorigenesis. Trends Genet. 2000;16:168–174
- . DNA methylation and cancer. J. Cell Physiol. 2000;183:145–154
- . Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat. Genet. 1999;21:103–107
- Loss of p73 gene expression in leukemia/lymphomas due to hypermethylation. Blood. 1999;94:1113–1120
- Loss of p73 gene expression in lymphoid leukemia cell lines is associated with hypermethylation. Leuk. Res. 2001;25:441–447
- . 5-Aza-2′-deoxycytidine induces terminal differentiation of leukemic blasts from patients with acute myeloid leukemia. Blood. 1984;64:922–929
- . Effect of 5-aza-2′-deoxycytidine and retinoic acid on differentiation and c-myc expression in HL-60 myeloid leukemic cells. Cancer Lett. 1990;54:21–28
- Phase I study on 5-aza-2′-deoxycytidine in children with acute leukemia. Leuk. Res. 1981;5:453–462
-
.
Clinical trial on 5-aza-2′-deoxycytidine in patients with acute leukemia.
Pharma. Ther. 1985;30:277–286
- . The antileukaemic activity of 5-aza-2′-deoxycytidine (Aza-dC) in patients with relapsed and resistant leukaemia. Br. J. Cancer. 1991;64:144–148
- . Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells. J. Natl. Cancer Inst. 2000;92:1210–1216
- . Histone deacetylase: a regulator of transcription. Science. 1996;272:371–372
- . Histone acetylation and cancer. Curr. Opin. Genet. Dev. 1999;9:171–174
- . Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J. Biol. Chem. 1990;265:17174–17179
- Histone deacetylase inhibitors are the potent inducer/enhancer of differentiation in acute myeloid leukemia: a new approach to anti-leukemia therapy. Leukemia. 1999;13:1316–1324
- . Inhibitors of histone deacetylase relieve ETO-mediated repression and induce differentiation of AML1-ETO leukemic cells. Cancer Res. 1999;59:2766–2769
- Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo. Clin. Cancer Res. 2001;7:971–976
- Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nat. Genet. 1998;19:187–191
-
.
Antineoplastic action and expression of retinoic acid receptor β gene in breast carcinoma cells treated with 5-aza-2′-deoxycytidine and a histone deacetylase inhibitor.
Cancer Chem. Pharmacol. 2001;48:71–76
-
.
FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor.
Exp. Cell Res. 1998;41:126–133
- Depsipeptide (FR981228): a novel therapeutic agent with selective, in vitro activity against human B-cell chronic lymphocytic leukemia cells. Blood. 1999;94:1401–1408
-
FR901228, a novel antitumor antibiotic bicyclic depsipeptide produced by Chromobacterium violaceum no. 968. III. Antitumor activities on experimental tumors in mice.
J. Antibiotics. 1994;47:315–323
- Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature. 1998;393:386–389
-
.
High-performance liquid chromatographic analysis of chemical stability of 5-aza-2′-deoxycytidine.
J. Pharma. Sci. 1981;70:1228–1232
-
.
In vitro systems for evaluation of combination chemotherapy.
Pharma. Ther. 1980;8:21–25
-
.
Acute myeloid leukemia.
New Engl. J. Med. 1999;341:1051–1062
- Long-term survival after induction therapy with idarubicin and cytosine arabinoside for de novo acute myeloid leukemia. Ann. Hematol. 2000;79:533–542
- . Therapeutic targeting of transcription in acute promyelocytic leukemia by use of an inhibitor of histone deacetylase. J. Natl. Cancer Inst. 1998;90:1621–1625
- Chronic myelogenous leukemia in nonlymphoid blastic phase: analysis of the results of first salvage therapy with three different treatment approaches for 162 patients. Cancer. 1999;86:2632–2641
- Low-dose 5-aza-2′-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: a multicenter phase II study in elderly patients. J. Clin. Oncol. 2000;18:956–962
- . Comparison of the antileukemic activity of 5-aza-2′-deoxycytidine, 1-β-d-arabinofuranosylcytosine and 5-azacytidine against L1210 leukemia. Leuk. Res. 1984;8:1043–1049
- . Inhibition of DNA methylation in L1210 leukemic cells by 5-aza-2′-deoxycytidine as possible mechanism of chemotherapeutic action. Cancer Res. 1983;43:3493–3496
- . 5-AZA-2′-deoxycytidine in patients with acute leukemia inhibits DNA methylation. Leuk. Res. 1984;8:181–185
- . Effects of a novel antitumor depsipeptide, FR901228, on human breast cancer cells. Breast Cancer Res. Treat. 1998;51:29–38
- Sequential 5-Aza-2′-deoxycytidine-depsipeptide FR901228 treatment induces apoptosis preferentially in cancer cells and facilitates their recognition by cytolytic T lymphocytes specific for NY-ESO-1. J. Immunother. 2001;24:151–161
- Pilot phase I–II study on 5-aza-2′-deoxycytidine (decitabine) in patients with metastatic lung cancer. Anticancer Drugs. 1997;8:358–368
-
Gore SD, Carducci MA. Modifying histones to tame cancer: clinical development of sodium phenylbutyrate and other histone deacetylase inhibitors. Exp. Opin. Invest. Drugs 2000;9:2923–34.
-
.
Molecular cellular and animal pharmacology of 5-aza-2′-deoxycytidine.
Pharma. Ther. 1985;30:287–299
PII: S0145-2126(02)00222-9
doi: 10.1016/S0145-2126(02)00222-9
« Previous
Next »
Leukemia Research
Volume 27, Issue 5
, Pages 437-444
, May 2003
