Leukemia Research
Volume 27, Issue 5 , Pages 397-404 , May 2003

Refractory anemia with excess of blasts in transformation: analysis of reclassification according to the WHO proposals

  • Corinna Strupp

      Affiliations

    • Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University, Moorenstreet 5, Düsseldorf 40225, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49-211-8117720; fax: +49-211-8118853.
  • ,
  • Norbert Gattermann

      Affiliations

    • Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University, Moorenstreet 5, Düsseldorf 40225, Germany
  • ,
  • Aristoteles Giagounidis

      Affiliations

    • Department of Hematology, Oncology and Clinical Immunology, St. Johannes-Hospital, Duisburg, Germany
  • ,
  • Carlo Aul

      Affiliations

    • Department of Hematology, Oncology and Clinical Immunology, St. Johannes-Hospital, Duisburg, Germany
  • ,
  • Barbara Hildebrandt

      Affiliations

    • Department of Human Genetics, Heinrich-Heine-University, Düsseldorf, Germany
  • ,
  • Rainer Haas

      Affiliations

    • Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University, Moorenstreet 5, Düsseldorf 40225, Germany
  • ,
  • Ulrich Germing

      Affiliations

    • Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University, Moorenstreet 5, Düsseldorf 40225, Germany

Received 18 July 2002 ,Accepted 25 September 2002.

References 

  1. Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, et al.  Proposals for the classification of the myelodysplastic syndromes. Br. J. Haematol. 1982;51:189–199
  2. Germing U, Strupp C, Giagounidis AS, Meckenstock G, Aul C. RAEB-T: a heterogenous entity. Leuk. Res. 1999;23(Suppl. 1):A169
  3. Seymour JF, Estey EH. The prognostic significance of Auer rods in myelodysplasia. Br. J. Haematol. 1993;85:67–76
  4. Seymour JF, Estey EH. The contribution of Auer rods to the classification and prognosis of myeldysplastic syndromes. Leuk. Lymphoma. 1995;17:79–85
  5. Vallespi T, Sanz G, Torrabadella M, Irriguible D, Sanz MA. Auer rods in myelodysplastic syndromes (MDS): presence and significance. Blood. 1990;76(Suppl. 1):330a; (abstract)
  6. Michels SD, Saumur J, Arthur DC, Robison LL, Brunning RD. Refractory anemia with excess of blasts in transformation: hematologic and clinical study of 52 patients. Cancer. 1989;64:2340–2346
  7. Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink HK, Vardiman J, et al.  World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues. J. Clin. Oncol. 1999;17:3835–3849
  8. Bennett JM. World Health Organization classification of the acute leucemias and myelodysplastic syndrome. Int. J. Hematol. 2000;72:131–133
  9. Jaffe ES, Harris NL, Stein H, Vardiman JW. Pathology and genetics of tumours of haematopoietic and lymphoid tissues. Lyon: IARC Press; 2001. p. 47–9.
  10. Germing U, Gattermann N, Strupp C, Aivado M, Aul C. Validation of the WHO proposals for a new classification of primary myelodysplastic syndromes: a retrospective analysis of 1600 patients. Leuk. Res. 2000;24:983–992
  11. Ohyashiki K, Nishimaki J, Shoji N, Miyazawa K, Kimura Y, Ohyashiki JH. Re-evaluation of refractory anemia with excess of blasts in transformation. Leuk. Res. 2001;25:933–939
  12. Nosslinger T, Reisner R, Koller E, Gruner H, Tuchler H, Nowotny H, et al.  Myelodysplastic syndromes, from French–American–British to World Health Organization: comparison of classifications on 431 unselected patients from a single institution. Blood. 2001;98:2935–2941
  13. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J. Am. Stat. Assoc. 1958;53:457–481
  14. Cox DR. Regression models and life-tables. J. Roy. Stat. Soc. 1972;34:187–220
  15. Greenberg P, Cox C, LeBeau MM, Fenaux P, Morel P, Sanz G, et al.  International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood. 1997;89:2079–2088
  16. Aul C, Gattermann N, Heyll A, Germing U, Derigs G, Schneider W. Primary myelodysplastic syndromes: analysis of prognostic factors in 235 patients and proposals for an improved scoring system. Leukemia. 1992;6:52–59
  17. Morel P, Hebbar M, Lai JL, Duhamel A, Preudhomme C, Wattel E, et al.  Cytogenetic analysis has strong independent prognostic value in de novo myelodysplastic syndromes and can be incorporated in a new scoring system: a report on 408 cases. Leukemia. 1993;7:1315–1323
  18. Mufti G, Stevens J, Hamblin T, Machin D. Myelodysplastic syndromes; a scoring system with prognostic significance. Br. J. Haematol. 1985;59:425–433
  19. Sanz GF, Sanz MA, Vallespi T, Canizo MC, Torrabadella M, Garcia S, et al.  Two regression models and a scoring system for predicting survival and planning treatment in myelodysplastic syndromes. A multivariate analysis of prognostic factors in 370 patients. Blood. 1989;74:395–408
  20. Seigneurin D, Audhuy B. Auer rods in refractory anemia with excess of blasts: presence and significance. Am. J. Clin. Pathol. 1983;80:359–362
  21. Bernardeschi P, Bonechi I. Prognostic significance of Auer rods in myelodysplastic syndromes. Br. J. Haematol. 1994;87:878–879

PII: S0145-2126(02)00220-5

doi: 10.1016/S0145-2126(02)00220-5

Leukemia Research
Volume 27, Issue 5 , Pages 397-404 , May 2003