Leukemia Research
Volume 27, Issue 3 , Pages 285-290 , March 2003

Masked MLL gene rearrangement was disclosed in the clinical course and sequential development of chromosome abnormality in a patient with therapy related acute myelogeneous leukemia

  • Shigeo Hashimoto

      Affiliations

    • First Department of Internal Medicine, Faculty of Medicine, Niigata University Medical Hospital, Niigata, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-25-227-2185; fax: +81-25-227-0774.
    • ,
  • Ken Toba

      Affiliations

    • First Department of Internal Medicine, Faculty of Medicine, Niigata University Medical Hospital, Niigata, Japan
    • ,
  • Noriko Izumi

      Affiliations

    • First Department of Internal Medicine, Faculty of Medicine, Niigata University Medical Hospital, Niigata, Japan
    • ,
  • Naoko Sato

      Affiliations

    • First Department of Internal Medicine, Faculty of Medicine, Niigata University Medical Hospital, Niigata, Japan
    • ,
  • Hidenobu Takahashi

      Affiliations

    • First Department of Internal Medicine, Faculty of Medicine, Niigata University Medical Hospital, Niigata, Japan
    • ,
  • Takuya Ozawa

      Affiliations

    • First Department of Internal Medicine, Faculty of Medicine, Niigata University Medical Hospital, Niigata, Japan
    • ,
  • Masato Moriyama

      Affiliations

    • First Department of Internal Medicine, Faculty of Medicine, Niigata University Medical Hospital, Niigata, Japan
    • ,
  • Sadao Aoki

      Affiliations

    • First Department of Internal Medicine, Faculty of Medicine, Niigata University Medical Hospital, Niigata, Japan
    • ,
  • Tatsuo Furukawa

      Affiliations

    • First Department of Internal Medicine, Faculty of Medicine, Niigata University Medical Hospital, Niigata, Japan
    • ,
  • Miwako Narita

      Affiliations

    • School of Health Sciences, Faculty of Medicine, Niigata University, Niigata, Japan
    • ,
  • Masuhiro Takahashi

      Affiliations

    • School of Health Sciences, Faculty of Medicine, Niigata University, Niigata, Japan
    • ,
  • Yoshifusa Aizawa

      Affiliations

    • First Department of Internal Medicine, Faculty of Medicine, Niigata University Medical Hospital, Niigata, Japan

Received 25 April 2002 ,Accepted 5 August 2002.

References 

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  3. Bodner SM, Naeve CW, Rakestraw KM, Jones BG, Valentine VA, Valentine MB, et al.  Cloning and chromosomal localization of the gene encoding human cyclin D-binding Myb-like protein (hDMP1). Gene. 1999;229:223–228
  4. Willman CL, Sever CE, Pallavicini MG, Harada H, Tanaka N, Slovak ML, et al.  Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia. Science. 1993;259:968–971
  5. Ziemin-van der Poel S, McCabe NR, Gill HJ, Espinosa R, Patel Y, Harden A, et al.  Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias. Proc. Natl. Acad. Sci. U.S.A. 1991;88:10735–10739
  6. Miyoshi H, Shimizu K, Kozu T, Maseki N, Kaneko Y, Ohki M. t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1. Proc. Natl. Acad. Sci. U.S.A. 1991;88:10431–10434
  7. Tanzer J, Najean Y, Frocrain C, Bernheim A. Chronic myelocytic leukemia with a masked Ph1 chromosome. N. Engl. J. Med. 1977;296:571–572
  8. Toba K, Koike T, Watanabe K, Fuse I, Takahashi M, Hashimoto S, et al.  Cell kinetics study of normal human bone marrow hematopoiesis and acute leukemia using 7AAD/PY. Eur. J. Haematol. 2000;64:10–21
  9. Johnson E, Cotter FE. Monosomy 7 and 7q− associated with myeloid malignancy. Blood Rev. 1997;11:46–55
  10. Joh T, Kagami Y, Yamamoto K, Segawa T, Takizawa J, Takahashi T, et al.  Identification of MLL and chimeric MLL gene products invoved in 11q23 translocation and possible mechanisms of leukemogenesis by MLL truncation. Oncogene. 1996;13:1945–1953
  11. Pui CH, Frankel LS, Caroll AJ, Raimodi SC, Shuster JJ, Head DR, et al.  Clinical characteristics and treatment outcome of childhood acute lymphoblastic leukemia with the t(4;11)(q21;q23): a collaborative study of 40 cases. Blood. 1991;77:440–447
  12. Rubnitz JE, Behm FG, Downing JR. 11q23 rearrangements in acute leukemia. Leukemia. 1996;10:74–82
  13. Yu M, Honoki K, Anderson J, Paietta E, Nam DK, Yunis JJ. MLL tandem duplication and multiple splicing in adult acute myeloid leukemia with normal karyotype. Leukemia. 1996;10:774–780
  14. Kitazawa J, Umenai T, Ito E, Arai K, Otomo H, Toki T, et al.  Progression from myelodysplastic syndrome with monosomy 7 to acute monoblastic leukemia with MLL gene rearrangement. Int. J. Hematol. 1998;67:23–26

PII: S0145-2126(02)00176-5

Leukemia Research
Volume 27, Issue 3 , Pages 285-290 , March 2003

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