Leukemia Research
Volume 27, Issue 3 , Pages 231-234, March 2003

The spectrum of acute lymphoblastic leukemia with mature B-cell phenotype

  • Natalie P.H. Chan

      Affiliations

    • Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    • ,
  • Edmond S.K. Ma

      Affiliations

    • Division of Hematology, Department of Pathology, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong
    • Corresponding Author InformationCorresponding author. Tel.: +852-2855-4570; fax: +852-2817-7565.
    • ,
  • Thomas S.K. Wan

      Affiliations

    • Division of Hematology, Department of Pathology, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong
    • ,
  • Li Chong Chan

      Affiliations

    • Division of Hematology, Department of Pathology, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong

Received 21 May 2002; accepted 1 June 2002.

Abstract 

We showed heterogeneous disease spectrum among 15 acute lymphoblastic leukemia (ALL) cases with mature B-cell phenotype diagnosed over the past 7 years at our institution. Besides those with typical L3 morphology and 8q24 (c-myc) translocation (n=6), there were cases showing L1 or L2 morphology without 8q24 translocation (n=6), unusually large L3 blasts in hyperdiploid clone (n=2) and blastoid variant of mantle cell lymphoma (n=1). The expression of CD5 and cyclin D1 may need to be routinely determined on ALL cases with mature B-cell phenotype and non-L3 morphology to facilitate timely diagnosis of blastoid MCL and institution of suitable management.

Abbreviations: ALL, acute lymphoblastic leukemia, FAB, French American British classification, MCL, mantle cell lymphoma, SmIg, surface membrane immunoglobulin

Keywords: Acute lymphoblastic leukemia, Mature B-cell, Morphology, Immunophenotype, Cytogenetics

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PII: S0145-2126(02)00129-7

Leukemia Research
Volume 27, Issue 3 , Pages 231-234, March 2003

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