Leukemia Research
Volume 27, Issue 1 , Pages 85-87 , January 2003

A unique case of splenic marginal zone-cell lymphoma with synchronous clonal T-cell large granular lymphocyte proliferation: an immunologic, immunohistochemical and genotypic study

  • T Papadaki

      Affiliations

    • Hemopathology Department and Immunology Laboratory, Evangelismos Hospital, Athens University, Athens, Greece
    • ,
  • K Stamatopoulos

      Affiliations

    • First Department of Medicine, University of Athens, Laikon General Hospital, Athens, Greece
    • Corresponding Author InformationCorresponding author. Present address: P.O. Box 51, 57010 Asvestohori, Thessaloniki, Greece. Tel.: +30-310-359172; fax: +30-310-359172.
    • ,
  • C Kosmas

      Affiliations

    • First Department of Medicine, University of Athens, Laikon General Hospital, Athens, Greece
    • ,
  • V Kapsimali

      Affiliations

    • Immunology Laboratory, Evangelismos Hospital, Athens, Greece
    • ,
  • T Economopoulos

      Affiliations

    • Second Department of Propaedentic Medicine, University of Athens, Evangelismos Hospital, Athens, Greece

Received 4 March 2002 ,Accepted 30 March 2002.

References 

  1. De Wolf-Peters C, Marginal zone-related lymphomas. Abstract book, B-Cell lymphoproliferative disorders II meeting. Amsterdam, 2001. p 55.
  2. Lamy T, Loughran TP. Current concepts: large granular lymphocyte leukemia. Blood Rev. 1999;13:230–240
  3. Xiros N, Economopoulos T, Fountzilas G, Pavlidis N, Samantas E, Raptis S. A phase II study with idarubicin, etoposide and prednisone (IVPP) in patients with refractory or early relapsed intermediate or high grade non-Hodgkin’s lymphoma. Haematologica. 1999;84:189–190
  4. Stamatopoulos K, Kosmas C, Belessi C, Papadaki Th, Afendaki S, Anagnostou D, et al.  t(14;18) in follicular lymphoma: an event occurring with almost equal frequency both at the D to JH and at later stages in the rearrangement process of the immunoglobulin heavy chain gene locus. Br. J. Haematol. 1997;99:866–872
  5. Diss TC, Peng H, Wotherspoon AC, Isaacson PG, Pan L. Detection of monoclonality in low-grade B-cell lymphomas using the polymerase chain reaction is dependent on primer selection and lymphoma type. J. Pathol. 1993;169:291–295
  6. Diss TC, Watts M, Pan LX, Burke M, Linch D, Isaacson PG. The polymerase chain reaction in the demonstration of monoclonality in T-cell lymphomas. J. Clin. Pathol. 1995;48:1045–1050
  7. Neale GA, Menarguez J, Kitchingman GR, Fitzgerald TJ, Koehler M, Mirro J, et al.  Detection of minimal residual disease in T-acute lymphoblastic leukemia using polymerase chain reaction predicts impending relapse. Blood. 1991;78:739–747
  8. Bassan R, Pronesti M, Buzzetti M, Allavena P, Rambaldi A, Mantovani A, et al.  Autoimmunity and B-cell disfunction in chronic proliferative disorders of large granular lymphocytes. Cancer. 1989;63:90–95
  9. Moss PA, Gillespie G. Clonal populations of T-cells in patients with B-cell malignancies. Leuk Lymhoma. 1997;27:231–238

PII: S0145-2126(02)00128-5

Leukemia Research
Volume 27, Issue 1 , Pages 85-87 , January 2003

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