Leukemia Research
Volume 27, Issue 1 , Pages 85-87, January 2003

A unique case of splenic marginal zone-cell lymphoma with synchronous clonal T-cell large granular lymphocyte proliferation: an immunologic, immunohistochemical and genotypic study

  • T Papadaki

      Affiliations

    • Hemopathology Department and Immunology Laboratory, Evangelismos Hospital, Athens University, Athens, Greece
    • ,
  • K Stamatopoulos

      Affiliations

    • First Department of Medicine, University of Athens, Laikon General Hospital, Athens, Greece
    • Corresponding Author InformationCorresponding author. Present address: P.O. Box 51, 57010 Asvestohori, Thessaloniki, Greece. Tel.: +30-310-359172; fax: +30-310-359172.
    • ,
  • C Kosmas

      Affiliations

    • First Department of Medicine, University of Athens, Laikon General Hospital, Athens, Greece
    • ,
  • V Kapsimali

      Affiliations

    • Immunology Laboratory, Evangelismos Hospital, Athens, Greece
    • ,
  • T Economopoulos

      Affiliations

    • Second Department of Propaedentic Medicine, University of Athens, Evangelismos Hospital, Athens, Greece

Received 4 March 2002; accepted 30 March 2002.

Abstract 

We describe a case of synchronous splenic marginal zone-cell lymphoma (SMZL) and T-cell large granular lymphocyte leukemia involving the spleen, liver, bone marrow and peripheral blood. The synchronous occurrence of these two processes was documented by morphological, immunophenotypical and molecular (PCR) analyses of all affected tissues. The pathogenetic mechanisms which may be responsible for the concomitant appearance of these two rather infrequent entities in the same anatomic sites are discussed.

Keywords:  Non-Hodgkin’s lymphoma, Large granular lymphocyte leukemia

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0145-2126(02)00128-5

Leukemia Research
Volume 27, Issue 1 , Pages 85-87, January 2003

Article Tools