A unique case of splenic marginal zone-cell lymphoma with synchronous clonal T-cell large granular lymphocyte proliferation: an immunologic, immunohistochemical and genotypic study

Received 4 March 2002; accepted 30 March 2002.

Abstract

We describe a case of synchronous splenic marginal zone-cell lymphoma (SMZL) and T-cell large granular lymphocyte leukemia involving the spleen, liver, bone marrow and peripheral blood. The synchronous occurrence of these two processes was documented by morphological, immunophenotypical and molecular (PCR) analyses of all affected tissues. The pathogenetic mechanisms which may be responsible for the concomitant appearance of these two rather infrequent entities in the same anatomic sites are discussed.

Keywords: Non-Hodgkin’s lymphoma, Large granular lymphocyte leukemia

a Hemopathology Department and Immunology Laboratory, Evangelismos Hospital, Athens University, Athens, Greece

b First Department of Medicine, University of Athens, Laikon General Hospital, Athens, Greece

c Immunology Laboratory, Evangelismos Hospital, Athens, Greece

d Second Department of Propaedentic Medicine, University of Athens, Evangelismos Hospital, Athens, Greece

Corresponding author. Present address: P.O. Box 51, 57010 Asvestohori, Thessaloniki, Greece. Tel.: +30-310-359172; fax: +30-310-359172.

PII: S0145-2126(02)00128-5

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