Leukemia Research
Volume 27, Issue 3 , Pages 215-220 , March 2003

Hematopoietic recovery after unrelated umbilical cord-blood allogeneic transplantation in adults treated with in vivo stem cell factor (R-MetHuSCF) and filgrastim administration

  • Punit D Wadhwa

      Affiliations

    • Allogeneic Transplant Program, Case Western Reserve University, Department of Medicine, Ireland Comprehensive Cancer Center, University Hospitals of Cleveland, 11100 Euclid Avenue, Wearn 433, Cleveland, OH 44106-5065, USA
  • ,
  • Hillard M Lazarus

      Affiliations

    • Allogeneic Transplant Program, Case Western Reserve University, Department of Medicine, Ireland Comprehensive Cancer Center, University Hospitals of Cleveland, 11100 Euclid Avenue, Wearn 433, Cleveland, OH 44106-5065, USA
  • ,
  • Omer N Koc

      Affiliations

    • Allogeneic Transplant Program, Case Western Reserve University, Department of Medicine, Ireland Comprehensive Cancer Center, University Hospitals of Cleveland, 11100 Euclid Avenue, Wearn 433, Cleveland, OH 44106-5065, USA
  • ,
  • Jennifer Jaroscak

      Affiliations

    • Department of Paediatrics, University Hospital of Cleveland, Case Western Reserve University, Cleveland, OH 44106-5065, USA
  • ,
  • David Woo

      Affiliations

    • Amgen Inc., Thousand Oaks, CA 91320, USA
  • ,
  • Cladd E Stevens

      Affiliations

    • Placental Blood Program, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10021, USA
  • ,
  • Pablo Rubinstein

      Affiliations

    • Placental Blood Program, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10021, USA
  • ,
  • Mary J Laughlin

      Affiliations

    • Allogeneic Transplant Program, Case Western Reserve University, Department of Medicine, Ireland Comprehensive Cancer Center, University Hospitals of Cleveland, 11100 Euclid Avenue, Wearn 433, Cleveland, OH 44106-5065, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-216-844-4766; fax: +1-216-844-3616.

Received 29 October 2001 ,Accepted 8 May 2002.

References 

  1. Rubinstein P, Carrier C, Scaradavou A, et al.  Outcomes among 562 recipients of placental-blood transplants from unrelated donors. New Engl. J. Med. 1998;339:1565–1577
  2. Gluckman E, Rocha V, Boyer-Chammard A, et al.  Outcome of cord-blood transplantation from related and unrelated donors. New Engl. J. Med. 1997;337:373–381
  3. Kurtzberg J, Laughlin M, Graham M, et al.  Placental blood as a source of hematopoetic stem cells for transplantation into unrelated recipients. New Engl. J. Med. 1996;335:155–166
  4. Wagner J, Rosenthal J, Sweetman R, et al.  Successful transplantation of HLA-matched and HLA-mismatched umbilical cord blood from unrelated donors: analysis of engraftment and acute graft-versus-host disease. Blood. 1996;88:795–802
  5. Laughlin MJ, Barker J, Bambach B, et al.  Hematopoietic engraftment and survival after unrelated donor umbilical cord-blood transplantation in adult recipients. New Engl. J. Med. 2001;344:1815–1822
  6. McNiece I, Kubegov D, Kerzic P, et al.  Increased expansion and differentiation of cord-blood products using a two-step expansion culture. Exp. Hematol. 2000;28:1181–1186
  7. Koller MR, Manchel I, Maher RJ, et al.  Clinical-scale human umbilical cord-blood cell expansion in a novel automated perfusion culture system. Bone Marrow Transplant. 1998;21:653–663
  8. Pecora AL, Stiff P, Jennis A, et al.  Prompt and durable engraftment in two older adult patients with high risk chronic myelogeneous leukemia (CML) using ex vivo expanded and unmanipulated unrelated umbilical cord blood. Bone Marrow Transplant. 2000;25:797–799
  9. Stiff P, Pecora A, Parthasarthy M, et al.  Umbilical cord-blood transplants in adults using a combination of unexpanded and ex vivo expanded cells: preliminary clinical observations. Blood. 1998;92:646a
  10. Barker J, McGlave P, Weisdorf D, et al.  Creation of a double chimera by transplantation of two unrelated donor umbilical cord-blood units. Blood. 2000;96:207a
  11. Brandt J, Briddell RA, Srour EF, et al.  Role of c-kit ligand in the expansion of human hematopoietic progenitor cells. Blood. 1992;79:634–641
  12. Duarte RF, Frank DA. SCF and G-CSF lead to the synergistic induction of proliferation and gene expression through complementary signaling pathways. Blood. 2000;96:3422–3430
  13. Rubinstein P, Dobrila L, Rosenfield RE, et al.  Processing and cryopreservation of placental/umbilical cord blood for unrelated bone marrow reconstitution. Proc. Natl. Acad. Sci. U.S.A. 1995;92:10119–10122
  14. Dewald G, Stallard R, Al Saadi A, et al.  A multicenter investigation with interphase fluorescence in situ hybridization using X- and Y-chromosome probes. Am. J. Med. Genet. 1998;67:216–318
  15. Sullivan BA, Jenkins LS, Karson EM, et al.  Evidence for structural heterogeneity from molecular cytogenetic analysis of dicentric Robertsonian translocations. Am. J. Hum. Genet. 1996;59:167–175
  16. Przepiorka D, Weisdorf D, Martin P, et al.  Consensus conference on acute GVHD grading. Bone Marrow Transplant. 1994;13:389–396
  17. Flowers M, Kansu E, Sullivan K. Pathophysiology and treatment of graft-versus-host disease. Hematol. Oncol. Clin. North Am. 1999;13:1091–1112
  18. Laughlin MJ. Umbilical cord blood for allogeneic transplantation in children and adults. Bone Marrow Transplant. 2001;27:1–6
  19. Andrews RG, Knitter GH, Bartelmez SH, et al.  Recombinant human stem cell factor, a c-kit ligand, stimulates hematopoiesis in primates. Blood. 1991;78:1975–1980
  20. Avraham H, Vannier E, Cowley S, et al.  Effects of the stem cell factor, c-kit ligand, on human megakaryocytic cells. Blood. 1992;79:365–371
  21. Andrews RG, Bensinger WI, Knitter GH, et al.  The ligand for c-kit, stem cell factor, stimulates the circulation of cells that engraft lethally irradiated baboons. Blood. 1992;80:2715–2720
  22. Andrews RG, Briddell RA, Knitter GH, et al.  In vivo synergy between recombinant human stem cell factor and recombinant human granulocyte colony-stimulating factor in baboons enhanced circulation of progenitor cells. Blood. 1994;84:800–810
  23. Crawford J, Lau D, Erwin R, et al.  A phase I trial of recombinant methionyl human stem cell factor (SCF) in patients with advanced non-small cell lung carcinoma (NSCLC). Proc. Ann. Meet. Am. Soc. Clin. Oncol. 1993;12:338a
  24. Kurtzberg J, Meyers F, Mcguire B, Crawford J. Mobilization of peripheral blood progenitor cells in patients given recombinant methionyl human stem cell factor. Proc. Ann. Meet. Am. Assoc. Cancer Res. 1993;34:1257a
  25. Moskowitz CH, Stiff P, Gordon MS, et al.  Recombinant methionyl human stem cell factor and filgrastim for peripheral blood progenitor cell mobilization and transplantation in non-Hodgkin’s lymphoma patients: results of a phase I/II trial. Blood. 1997;89:3136–3147
  26. Facon T, Harousseau JL, Maloisel F, et al.  Stem cell factor in combination with filgrastim after chemotherapy improves peripheral blood progenitor cell yield and reduces apheresis requirements in multiple myeloma patients: a randomized, controlled trial. Blood. 1999;94:1218–1225
  27. Kurtzberg J, Jaroscak J, Martin PL, et al.  Augmentation of umbilical cord-blood (UCB) transplantation with ex vivo expanded cells: a phase I trial using the replicell system. Blood. 1999;94:571a
  28. Shpall E, Quinones R, Giller R, et al.  Transplantation of adult and paediatric cancer patients with cord-blood progenitors expanded ex vivo. Blood. 2000;96:206a

PII: S0145-2126(02)00090-5

Leukemia Research
Volume 27, Issue 3 , Pages 215-220 , March 2003