Leukemia Research
Volume 27, Issue 1 , Pages 45-50 , January 2003

Dental abnormalities in children after chemotherapy treatment for acute lymphoid leukemia

  • Eliana Maria Minicucci

      Affiliations

    • Department of Pathology, School of Medicine of Botucatu, São Paulo State University, São Paulo, SP, Brazil
    • Corresponding Author InformationCorresponding author. Tel.: +55-14-8220982; fax: +55-14-8220982.
    • ,
  • Luiz Fernando Lopes

      Affiliations

    • Department of Pediatrics of the Cancer Hospital, São Paulo, SP, Brazil
    • ,
  • Adalberto José Crocci

      Affiliations

    • Department of Statistics, Bioscience Institute of Botucatu, São Paulo State University, São Paulo, SP, Brazil

Received 15 September 1998 ,Accepted 27 April 2002.

References 

  1. Kaste SC, Hopkins KP, Jenkins JJ. Abnormal odontogenesis in children treated with radiation and chemotherapy, imaging findings. Am. J. Roentgenol. 1994;162:1407
  2. Engelmeier RL, King GE. Complications of head and neck radiation therapy and their management. J. Prosthet. Dent. 1983;49:514
  3. Fromm M, Littman P, Raney RB, Nelson L, Handler S, Diamond G, et al.  Late effects after treatment of 20 children with soft tissue sarcomas of the head and neck. Cancer. 1986;57:2070
  4. Goho C. Chemoradiationtherapy: effect on dental development. Pediatr. Dent. 1993;15:6
  5. Goodman ED, Iuks AB. The effects of anti-leukemia therapy on the developing dentition: case report. Pediatr. Dent. 1985;7:318
  6. Gorlin RJ, Meskin LH. Severe irradiation during odontogenesis: report of a case. Oral Surg. Oral Med. Oral Pathol. 1963;16:35
  7. Hazra TA, Shipman B. Dental problems in pediatric patients with head and neck tumors undergoing multiple modality therapy. Med. Pediatr. Oncol. 1982;10:91
  8. Karim AC, Eddy EL. A light and electron microscopic study of osteodentin formation in the rat incisor after adriamycin administration. Am. J. Anat. 1984;169:207
  9. Maxymiw WG, Wood RE. The role of dentistry in head and neck radiation therapy. J. Can. Dent Assoc. 1989;55:193
  10. Petrokovski J, Menezel J. Tooth dwarfism and root underdevelopment following irradiation. Oral Surg. Oral Med. Oral Pathol. 1966;22:95
  11. Weyman J. The effect of irradiation on developing teeth. Oral Surg. Oral Med. Oral Pathol. 1968;25:263
  12. Rosemberg SW. Oral complications of cancer chemotherapy—a review of 398 patients. J. Oral Med. 1986;41:93
  13. Rosemberg SW, Kolodney H, Wong GY, Murphy ML. Altered dental root development in long-term survivors of pediatric acute lymphoblastic leukemia. Cancer. 1987;59:1640
  14. Williams MC, Martin MV. A longitudinal study of the effects on the oral mucosa of treatment for acute childhood leukemia. Int. J. Pediatr. Dent. 1992;2:73
  15. Dahllof G, Nasman M, Borgstrom A, Modeer T, Forsberg CM, Heimdahl A, et al.  Effect of chemotherapy on dental maturity in children with hematological malignancies. Pediatr. Dent. 1989;11:303
  16. Dahllof G, Rozell B, Forsberg CM, Borgstrom B. Histologic changes in dental morphology induced by high-dose chemotherapy and total body irradiation. Oral Surg. Oral Med. Oral Pathol. 1994;77:56
  17. Jaffe N, Toth BB, Hoar RE, Ried HL, Sullivan MP, McNeese MD. Dental and maxillofacial abnormalities in long-term survivors of childhood cancer. Effects of treatment with chemotherapy and radiation to the head and neck. Pediatrics. 1984;73:816
  18. Macleod RI, Welbury RR, Soames JV. Effects of cytotoxic chemotherapy on dental development. J. R. Soc. Med. 1987;80:207
  19. Maguire A, Craft AW, Evans RGB, Aminiddine H, Kernahan J, Macleod RI, et al.  The long-term effects of treatment on the dental condition of children surviving malignant diseases. Cancer. 1987;60:2570
  20. Purdell-Lewis DJ, Stalman MS, Leeuw JA, Humphrey GB, Kalsbeek H. Long-term results of chemotherapy on the developing dentition, caries risk and developmental aspects. Community Dent. Oral. Epidemiol. 1988;16:68
  21. Sonis LA, Tarbell N, Valochovic RW, Gelber R, Schwenn M, Sallan S. Dentofacial development in long-term survivors of acute lymphoblastic leukemia. A comparison of three treatment modalities. Cancer. 1990;66:2645
  22. Kosowicz J, Rzymski K. Abnormalities of tooth development in pituitary dwarfism. Oral Surg. Oral Med. Oral Pathol. 1977;44:853
  23. Sarnat H, Kaplan I, Pertzelan A, Laron Z. Comparisons of dental findings in patients with isolated growth hormone deficiency treated with human growth hormone (hGH) and in untreated patients with Laron-type dwarfism. Oral Surg. Oral Med. Oral Pathol. 1988;66:581
  24. Adatia AK. Response of the dental elements to chemotherapy of Burkitt’s tumor. Int. Dent. J. 1968;18:646
  25. Adatia AK. The effects of cyclophosphamide on odontogenesis in the rat. Arch. Oral. Biol. 1975;20:141
  26. Moxham BJ, Berkovitz BK. Interactions between thyroxine hydrocortisone and cyclophosphamide in their effects on the eruption of the rat mandibular incisor. Arch. Oral. Biol. 1983;28:1083
  27. Reade PC, Roberts ML. Some long-term effects of cyclophosphamide on the growth of rat incisor teeth. Arch. Oral. Biol. 1978;23:1001
  28. Vahlsing HL, Faringa ER, Britten AG, Kinning WR. Dental abnormalities in rats after a single large dose of cyclophsphamide. Cancer Res. 1975;35:2199
  29. Chiba M, Nakagawa K, Minura T. Estimation of mitotic rate and mitotic duration in the internal enamel epithelium of the rat maxillary incisor using a colchidine technique. Arch. Oral. Biol. 1966;11:803
  30. Robins MW. The proliferation of pulp cells in rat incisor. Arch. Oral. Biol. 1967;12:487
  31. Karim AC, Eddy EL. A light and electron microscopic study of osteodentin formation in the rat incisor after adriamycin administration. Am. J. Anat. 1984;169:207
  32. Karim AC. The initiation of osteodentin formation in the rat incisor after adriamycin administration. Anat. Rec. 1985;213:377
  33. Brandalise S, Odone V, Pereira W, Andrea W, Zanchelli M, Aranega V. Treatment results of three consecutive Brazilian cooperative childhood ALL Protocols, GBTLI-80, GBTLI-82 and GBTLI-85: ALL Brazilian Group. Leukemia. 1993;7(Suppl. 2):142
  34. Reiter A, Schrappe M, Ludwig WD, Hiddemann SS, Henze G, Zimmermann M, et al.  Chemotherapy in 998 selected childhood acute lymphoblastic leukemia patients. Results and conclusions of the multi-center trial ALL-BFM86. Blood. 1994;84:3122
  35. Goodman LA. Simultaneous confidence intervals for contrasts among multi-nodal populations. Ann. Math. Stat. 1964;35:716
  36. Kaste SC, Hopkins KP, Jones D, Crorn D, Greenwald CA, Santana VW. Dental abnormalities in children treated for acute lymphoblastic leukemia. Leukemia. 1997;11:792
  37. Welbury RR, Craft AW, Murray JJ, Kernahan J. Dental health of survivors of malignant disease. Arch. Dis. Child. 1984;59:1186
  38. Schroeder HE, Massler LA. The fine structure of the developing epithelial attachment of human teeth. In: Picosse M, editor. Anatomia Dentária. São Paulo: Sarvier, 1983. p. 200.

PII: S0145-2126(02)00080-2

Leukemia Research
Volume 27, Issue 1 , Pages 45-50 , January 2003

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