Leukemia Research
Volume 27, Issue 1 , Pages 45-50, January 2003

Dental abnormalities in children after chemotherapy treatment for acute lymphoid leukemia

  • Eliana Maria Minicucci

      Affiliations

    • Department of Pathology, School of Medicine of Botucatu, São Paulo State University, São Paulo, SP, Brazil
    • Corresponding Author InformationCorresponding author. Tel.: +55-14-8220982; fax: +55-14-8220982.
    • ,
  • Luiz Fernando Lopes

      Affiliations

    • Department of Pediatrics of the Cancer Hospital, São Paulo, SP, Brazil
    • ,
  • Adalberto José Crocci

      Affiliations

    • Department of Statistics, Bioscience Institute of Botucatu, São Paulo State University, São Paulo, SP, Brazil

Received 15 September 1998; accepted 27 April 2002.

Abstract 

The frequency of dental abnormalities, such as delayed dental development, microdontia, hypoplasia, agenesis, V-shaped root and shortened root was evaluated in 76 acute lymphoblastic leukemia (ALL) pediatric patients who had been off chemotherapy for 6 months. These children had been subjected to one of the three Brazilian Protocols or the BFM86 Protocol. The patients were divided into three groups: Group I (GI; high risk) treated with one of the three Brazilian Protocols who received high-dose chemotherapy, intensive maintenance and cranial radiotherapy; Group II (GII; low risk) who were also treated with one of the three Brazilian Protocols using low-intensive chemotherapy with no radiotherapy; and Group III (GIII) based on the BFM86 Protocol.

Of 76 children, 13 showed no dental abnormalities (8 were at the age of tooth formation). The remaining 63 children (82.9%) showed at least one dental anomaly.

The abnormalities were probably caused by the type, intensity, frequency of the treatment and age of the patients at ALL diagnosis and this might have important consequences for the children’s dental development.

Keywords:  Odontogenesis drugs effects, Antineoplastic agents adverse effects, Chemotherapy dental abnormalities, Late effects of ALL treatment

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0145-2126(02)00080-2

Leukemia Research
Volume 27, Issue 1 , Pages 45-50, January 2003

Article Tools

* Image Usage & Resolution