Leukemia Research
Volume 27, Issue 1 , Pages 13-17 , January 2003

Elevated thrombopoietin levels in patients with myelofibrosis may not be due to enhanced production of thrombopoietin by bone marrow

  • Jen C Wang

      Affiliations

    • Corresponding Author InformationCorresponding author. Present address: Maimonides Hospital Medical Center, Department of Hematology/Oncology, 953 49th Street, 5th Floor, Brooklyn, NY 11219, USA. Tel.: +1-718-283-8297; fax: 1-718-635-7110.
    • ,
  • Ghazala Hashmi

Received 20 February 2002 ,Accepted 9 April 2002.

References 

  1. Lok S, Kaushansky K, Holly RD, Kuijper JL, Lofton-Day CE, Oort PJ, et al.  Cloning and expression of murine thrombopoietin and stimulation of platelet production in vivo. Nature. 1994;369:565
  2. de Sauvage FJ, Hass PE, Spencer SD, Malloy BE, Gurney AL, Spencer SA, et al.  Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-MPL ligand. Nature. 1994;369:533
  3. Bartley TD, Bogenberger J, Hunt P, Li YS, Lu HS, Martin F, et al.  Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell. 1994;77:1117
  4. Wendling F, Marakovsky E, Debili N, Florindo C, Teepe M, Titeux M, et al.  c-MPL ligand is a humoral regulator of megakaryocytopoiesis. Nature. 1994;369:571
  5. Yang C, Li YC, Kuter DJ. The physiological response of thrombopoietin (c-MPL ligand) to thrombocytopenia in the rat. Br. J. Haematol. 1999;105:478
  6. Fielder PJ, Gurney AL, Stefanich E, Marian M, Moore MW, Carver-Moore K, et al.  Regulation of thrombopoietin levels by c-MPL-mediated binding to platelets. Blood. 1996;87:2154
  7. Fielder PJ, Hass P, Nagel M, Stefanich E, Widmer R, Bennett GL, et al.  Human platelets as a model for the binding and degradation of thrombopoietin. Blood. 1997;89:2782
  8. Hoe M, Andersson PO, Stockelberg D, Mellqvist UH, Ridell B, Wadenvik H. Plasma thrombopoietin levels in thrombocytopenic states: implication for a regulatory role of bone marrow megakaryocytes. Br. J. Haematol. 1998;101:420
  9. Yuka N, Yuka S, Hiroshi N, Toshiro N, Tsukasa A, Kazuo T. Serum Thrombopoietin level is not regulated by transcription but by the total counts of both megakaryocytes and platelets during thrombocytopenia and thrombocytosis. Thromb. Haemost. 1997;77:808
  10. Cohen-Solal K, Villeval J-L, Titeux M, Lok S, Vainchenker W, Wendling F. Constitutive expression of Mpl transcripts during thrombocytopenia or thrombocytosis. Blood. 1996;88:2578
  11. Hirayama Y, Sakamaki S, Matsunaga T, Kuga T, Kuroda H, Kusakabe T, et al.  Concentrations of thrombopoietin in bone marrow in normal subjects and in patients with idiopathic thrombocytopenic purpura, aplastic anemia, and essential thrombocythemia correlate with its mRNA expression of bone marrow stromal cells. Blood. 1998;92:46
  12. McCarty JM, Sprugel KH, Fox NE, Sabath DE, Kaushansky K. Murine thrombopoietin mRNA levels are modulated by platelet count. Blood. 1995;86:3668
  13. Sungaran R, Markovic B, Chong BH. Localization and regulation of thrombopoietin mRNA expression in human kidney, liver, bone marrow and spleen using in situ hybridization. Blood. 1997;89:101
  14. Stoffel R, Wiestner A, Skoda RC. Thrombopoietin in thrombocytopenic mice: evidence against regulation at the mRNA level and for a direct regulatory role of platelets. Blood. 1996;87:567
  15. Wang JC, Chen C, Lou L-H, Mora M. Blood thrombopoietin, IL-6 and IL-11 levels in patients with agnogenic myeloid metaplasia. Leukemia. 1997;11:1827
  16. Wang JC, Chen C, Novetsky AD, Lichter SM, Ahmed F, Friedberg NM. Blood thrombopoietin levels in clonal thrombocytosis and reactive thrombocytosis. Am J. Med. 1998;104:451
  17. Nichol JL. Serum levels of thrombopoietin in health and disease. In: Kuter DJ, Hunt P, Sheridan W, Zucker-Eranklin D, editors. Thrombopoiesis and thrombopoietin. Totowa, NJ: Humanae Press, 1997. p. 359.
  18. Cerutti A, Custodi P, Duranti M, Noris P, Balduini CL. Thrombopoietin levels in patients with primary and reactive thrombocytosis. Br. J. Haematol. 1997;99:281
  19. Moliterno AR, Hankins WD, Spivak JL. Impaired expression of the thrombopoietin receptor by platelets from patients with polycythemia vera. N. Eng. J. Med. 1998;338:572
  20. Horikawa Y, Matsumura I, Hashimoto K, Shiraga M, Kosugi S, Tadokoro S, et al.  Markedly reduced expression of platelet c-MPL receptor in essential thrombocythemia. Blood. 1997;90:4031
  21. Clarks DA, Williams WL. Myelofibrosis. In: Lee GR, Foerster J, Lukens J, Paraskevas F, Greer JP, Rogers GM, editors. Wintrobe’s clinical hematology. Baltimore: Willams and Wilkins, 1998. p. 2390.
  22. Wang JC, Lang H-D, Lichter S, Weinstein M, Benn P. Cytogenetic studies of bone marrow fibroblasts cultured from patients with myelofibrosis and myeloid metaplasia. Br. J. Haematol. 1992;80:184
  23. Dodd F, et al.  l-Arginine inhibits apoptosis via a NO-dependent mechanism in Nb2 lymphoma cells. J. Cell Biochem. 2000;77:624
  24. Hakak Y, Walker JR, Li C, Wong WH, Davis KL, Buxbaum JD, et al.  Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia. Proc. Natl. Acad. Sci. U.S.A. 2001;98:4746
  25. Li Z, et al.  A role for timeless in epithelial morphogenesis during kidney development. Proc. Natl. Acad. Sci. U.S.A. 2000;97:10038
  26. Oh SK, et al.  Molecular cloning, expression, and functional analysis of a cis-prenyltransferase from arabidopsis thaliana. J. Biol. Chem. 2000;275:18482
  27. Begum NA, Shibuta K, Mori M, Barnard GF. Reduced expression of the CXCR4 receptor mRNA in hepatocellular carcinoma and lack of inducibility of its ligand α-chemokine hIRH/SDF1α/PBSF in vitro. Int. J. Oncol. 1999;14:927
  28. Guerriero A, Worford L, Holand H-K, Guo G-R, Shehan K, Waller E-K. Thrombopoietin is synthesized by bone marrow stromal cells. Blood. 1997;90:3444
  29. Raeymaekers L. A commentary on the practical applications of competitive PCR. Genet. Res. 1995;5:91
  30. Saglio G, Pane F, Gottardi E, Frigeri F, Buonaoitp MR, Guerrasio A, et al.  Consistent amounts of acute leukemia-associate P190BCR/ABL transcripts are expressed by chornic myelogenous leukemia patients at diagnosis. Blood. 1996;87:1075
  31. Nomura S, Ogami K, Kawamura K, Tsukamoto I, Kudo Y, Kanakura Y, et al.  Cellular localization of thrombopoietin mRNA in the liver by in situ hybridization. Exp. Hematol. 1997;25:565
  32. Foster DC, Sprecher CA, Grant FJ, Kramer JM, Kuijper JL, Holly RD, et al.  Human thrombopoietin: gene structure, cDNA sequence, expression and chromosomal localization. Proc. Natl. Acad. Sci. U.S.A. 1994;91:13023
  33. Kiladjian II, Elkassar N, Hetet G, Briere J, Grandchamp B, Gardin C. Study of the thrombopoietin receptor in essential thrombocythemia. Leukemia. 1997;11:1821
  34. Yan X-Q, Lacey D, Hill D, Chen Y, Fletcher F, Hawley RG, et al.  A model of myelofibrosis and osteosclerosis in mice induced by overexpressing thrombopoietin c-MPL ligand: reversal of disease by bone marrow transplantation. Blood. 1996;88:102
  35. Villeval JL, Cohen-Solal K, Tulliez M, Giraudier S, Guichard J, Burstein SA, et al.  High thrombopoietin production by hematopoietic cells induces a fatal myeloproliferative syndrome in mice. Blood. 1997;90:4369

PII: S0145-2126(02)00069-3

Leukemia Research
Volume 27, Issue 1 , Pages 13-17 , January 2003

Article Tools

* Image Usage & Resolution