Leukemia Research
Volume 27, Issue 1 , Pages 57-64 , January 2003

Cytotoxic and inhibitory effects of 4,4′-dihydroxy chalcone (RVC-588) on proliferation of human leukemic HL-60 cells

  • Guray Saydam

      Affiliations

    • Department of Hematology, School of Medicine, Ege University, Bornova, Izmir, Turkey
  • ,
  • H.Hakan Aydin

      Affiliations

    • Department of Biochemistry, School of Medicine, Ege University, Bornova, Izmir, Turkey
  • ,
  • Fahri Sahin

      Affiliations

    • Department of Hematology, School of Medicine, Ege University, Bornova, Izmir, Turkey
  • ,
  • Ozlem Kucukoglu

      Affiliations

    • Department of Pharmaceutical Chemistry, School of Pharmacy, Ege University, Bornova, Izmir, Turkey
  • ,
  • Ercin Erciyas

      Affiliations

    • Department of Pharmaceutical Chemistry, School of Pharmacy, Ege University, Bornova, Izmir, Turkey
  • ,
  • Ender Terzioglu

      Affiliations

    • Department of Immunology, School of Medicine, Ege University, Bornova, Izmir, Turkey
  • ,
  • Filiz Buyukkececi

      Affiliations

    • Department of Hematology, School of Medicine, Ege University, Bornova, Izmir, Turkey
  • ,
  • Serdar Bedii Omay

      Affiliations

    • Department of Hematology, School of Medicine, Ege University, Bornova, Izmir, Turkey
    • Corresponding Author InformationCorresponding author. Tel.: +90-232-374-7321; fax: +90-232-374-7321.

Received 1 August 2001 ,Accepted 19 February 2002.

References 

  1. Hsieh HK, Lee TH, Wang JP, Way JJ, Lin CN. Synthesis and anti-inflammatory effect of chalcones and related compounds. Pharmacol. Res. 1998;15:39
  2. Torigoo T, Arisawa M, Iloch S, Fujiu M, Mayuyama HB. Anti-mutagenic chalcones: antagonising the mutagenicity of benzo(a)pyrene in Salmonella typhymurium. Biochem. Biophys. Res. Commun. 1983;112:833
  3. Satyanarayana K, Rao MNA. Anti-inflammatory, analgesic and anti-pyretic activities of 3-(4-(3-(4-dimethylaminophenyl)-1-oxo-2-propenyl) phenyle)sydrone. Indian Drugs. 1993;30:313
  4. Torigoo T, Arisawa M, Iloch S, Fujiu M, Mayuyama HB. Anti-mutagenic chalcones: antagonising the mutagenicity of benzo(a)pyrene in Salmonella typhymurium. Biochem Biophys Res Commun 1983;112:833.
  5. Anto RJ, Sukumaran K, Kuttan G, Rao MNA, Subbaraju V, Kuttan R. Anticancer and anti-oxidant activity of synthetic chalcones and related compounds. Cancer Lett. 1995;97:33
  6. Haruguchi H, Ishikawa H, Mizutani K, Tamura Y, Kinoshita T. Anti-oxidative and superoxide scavering activities of retrochalcones in Glycyrrhiza inflata. Bioorg. Med. Chem. 1998;6:339
  7. Ruby AJ, Kuttan G, Sathyanarayama K, Rao MNA. Tumor reducing and anti-oxidant activities of synthane-substituted chalcones. J. Clin. Biochem. Nutr. 1994;17:73
  8. Wattenberg LW, Coccia JB, Galhaith AR. Inhibition of carcinogen-induced pulmonary and mammary carcinogenesis by chalcones administered after carcinogen exposure. Cancer Lett. 1994;83:165.
  9. Edwards ML, Stemerick DM, Sunkara SP. Chalcone derivatives useful in controlling growth of tumor tissue and their preparation. Eur Pat Appl EP 288,794, 2 November 1988; Chem Abstr 111, 17706t.
  10. Vincenzo RD, Ferlini C, Distefano M, Gaggini C, Riva A, Bombardelli E, et al.  In vitro evaluation of newly developed chalcone analogues in human cancer cells. Cancer Chem. Pharmacol. 2000;46:305
  11. Sukumaran K, Kuttan R. Screening of 11 ferns of cytotoxic and antitumor potential with special reference of Pityrogramma calomelanos. J. Ethnopharmacol. 1991;36:93
  12. Kelloff GJ, Boone CW, Crowell JA, Steele VE, Lubet R, Sigman CC. Chemopreventive drug development; perspective and progress. Cancer Epidemiol, Biomark Prev 1994;3:85.
  13. Dimmock JR, Kumar P. Anticancer and cytotoxic properties of Mannich bases. Curr. Med. Chem. 1997;4:1
  14. Dimmock JR, Kandepu NM, Hetherington M, Quail JW, Pugazhenti U, Sudom AM, et al.  Cytotoxic activities of mannich bases of chalcones and related compounds. J. Med. Chem. 1998;41:1014
  15. Gordon LT, Weitzman SA. Inflammation and cancer. Cancer J. 1993;6:257
  16. Suolinna EM, Buchsbaum RN, Recker E. The effect of flavonoids on aerobic glycolysis and growth of tumor cells. Cancer Res. 1975;35:1865
  17. Chiou GC, Yao QS, Varma RS. Inhibition of ocular inflammation by chalcone derivatives and prednisolone. J. Ocular Pharmacol. 1992;8:213
  18. Böhme H, Hartke K. Über die Spaltung von aminalen und α-dialkylamino-athern mit carbonsaurehalogeniden. Chem. Ber. 1960;93:1305
  19. Vorlander D. Acid, salt, ester and addition product. Ber. Dtsch. Chem. 1925;58:118
  20. Yit CC, Das NP. Cytotoxic effect of butein on human colon adenocarcinoma cell proliferation. Cancer Lett. 1994;82:65
  21. Collins SJ, Bonder A, Ting R, Gallo RC. Induction of morphological and functional differentiation of human promyelocyte leukemia cells (HL-60) by compound which induce differentiation of murine leukemia cells. Int. J. Cancer. 1980;25:213
  22. Murao S, Gemmell MA, Callaham MF, Anderson NL, Huberman E. Control of macrophage cell differentiation in human promyelocytic HL-60 cells by 1, 25-dihydroxyvitamin D3 and phorbol-12-myristate-13 acetate. Cancer Res. 1983;43:4989
  23. Foon KA, Schroff MA, Gale RP. Surface markers on leukemia and lymphoma: recent advancer. Blood. 1982;60:1
  24. Takahashi T, Kobori M, Shinmoto H, Tsushida T. Structure–activity relationship of flavonoids and the induction of granulocytic-or monocytic-differentiation in HL-60 human myleoid leukemia cells. Biosci. Biotechnol. Biochem. 1998;62:2199
  25. Lee SK, Song L, Mata-Greenwood E, Kelloff GJ, Steele VE, Pezzuto JM. Modulation of in vitro biomarkers of the carcinogenic process by chemopreventive agents. Anticancer Res. 1999;19:35
  26. Iwashita K, Kobori M, Yamaki K, Tsushida T. Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells. Biosci. Biotechnol. Biochem. 2000;64:1813

PII: S0145-2126(02)00058-9

Leukemia Research
Volume 27, Issue 1 , Pages 57-64 , January 2003