Leukemia Research
Volume 27, Issue 1 , Pages 51-56 , January 2003

Cyclic AMP induces activation of extracellular signal-regulated kinases in HL-60 cells: role in cAMP-induced differentiation

  • Young-Jin Cho

      Affiliations

    • Department of Pharmacology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul 137-701, South Korea
    • ,
  • Ju-Young Kim

      Affiliations

    • Department of Pharmacology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul 137-701, South Korea
    • ,
  • Seong-Whan Jeong

      Affiliations

    • Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul, South Korea
    • ,
  • Sang Bok Lee

      Affiliations

    • Department of Pharmacology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul 137-701, South Korea
    • ,
  • Ok Nyu Kim

      Affiliations

    • Department of Pharmacology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul 137-701, South Korea
    • Corresponding Author InformationCorresponding author. Tel.: +82-2-590-1202; fax: +82-2-536-2485.

Received 20 July 2001 ,Accepted 11 March 2002.

References 

  1. Nonaka T, Mio M, Doi M, Tasaka K. Histamine-induced differentiation of HL-60 cells. Biochem. Pharmacol. 1992;44:1115–1121
  2. Jiang L, Foster FM, Ward P, Tasevski V, Luttrell BM, Conigrave AD. Extracellular ATP triggers cyclic AMP-dependent differentiation of HL-60 cells. Biochem. Biophys. Res. Commun. 1997;232:626–630
  3. Bang BE, Ericsen C, Aarbakke J. Effects of cAMP and cGMP elevating agents on HL-60 cell differentiation. Pharmacol. Toxicol. 1994;75:108–112
  4. Chaplinski TJ, Niedel JE. Cyclic nucleotide-induced maturation of human promyelocytic leukemia cells. J. Clin. Invest. 1982;70:953–964
  5. Das D, Pintucci G, Stern A. MAPK-dependent expression of p21WAF and p27kip1 in PMA-induced differentiation of HL-60 cells. FEBS Lett. 2000;472:50–52
  6. Marcinkowska E, Widlocha A, Radzikowski C. 1,25-Dihydroxyvitamin D3-induced activation and subsequent nuclear translocation of MAPK is upstream regulated by PKC in HL-60 cells. Biochem. Biophys. Res. Commun. 1997;241:419–426
  7. Yen A, Roberson MS, Varvayanis S, Lee AT. Retinoic acid-induced mitogen-activated protein (MAP)/extracellular-signal-regulated kinase (ERK) kinase-dependent MAP kinase activation needed to elicit HL-60 cell differentiation and growth arrest. Cancer Res. 1998;58:3163–3172
  8. Häfner S, Adler HS, Mischak H, Janosch P, Heidecker G, Wolfman A, et al.  Mechanism of inhibition of Raf-1 by protein kinase A. Mol. Cell. Biol. 1994;14:6696–6703
  9. Vossler MR, Yao H, York RD, Pan MG, Rim CS, Stork PJ. cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway. Cell. 1997;89:73–82
  10. de Rooij J, Zwartkruis FJ, Verheijen MH, Cool RH, Nijman SM, Wittinghofer A, et al.  Epac is a Rap1 guanine–nucleotide-exchange factor directly activated by cyclic AMP. Nature. 1998;396:474–477
  11. Kawasaki H, Springett GM, Mochizuki N, Toki S, Nakaya M, Matsuda M, et al.  A family of cAMP-binding proteins that directly activate Rap1. Science. 1998;282:2275–2279
  12. Choi JW, Cho Y-J, Cha SH, Lee KH, Lee SB. Distributional patterns of phospholipase C isozymes in heart and brain of spontaneously hypertensive rats. Korean J. Physiol. Pharmacol. 1997;1:385–392
  13. Cho Y-J, Ahn WS, Cha SH, Lee KH, Kim WI, Chung MH. Hydroxyl radical-mediated commitment of HL-60 cells to differentiation: modulation of differentiation process by phospholipase inhibitors. Korean J. Physiol. Pharmacol. 1998;2:369–376
  14. Yamashiro S, Takayama K, Shiku H, Furukawa K. Up-regulation of small GTP-binding proteins smg P21A and ras P21S during TPA-induced differentiation of human leukemia cell lines. Leuk. Res. 1993;17:129–136
  15. Kurachi H, Wada Y, Tsukamoto N, Maeda M, Kubota H, Hattori M, et al.  Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. J. Biol. Chem. 1997;272:28081–28088
  16. Scheele JS, Pilz RB, von Lintig FC, Boss GR. Deficient post-translational processing of Rap1A in variant HL-60 cells. Oncogene. 1998;17:2211–2223
  17. von Lintig FC, Pilz RB, Boss GR. Quantitative determination of Rap1 activation in cyclic nucleotide-treated HL-60 leukemic cells: lack of Rap1 activation in variant cells. Oncogene. 2000;19:4029–4034
  18. Yao H, York RD, Misra-Press A, Carr DW, Stork PJ. The cyclic adenosine monophosphate-dependent protein kinase (PKA) is required for the sustained activation of mitogen-activated kinases and gene expression by nerve growth factor. J. Biol. Chem. 1998;273:8240–8247
  19. Qiu W, Zhuang S, Lintig FC, Boss GR, Pilz RB. Cell type-specific regulation of B-Raf kinase by cAMP and 14-3-3 proteins. J. Biol. Chem. 2000;275:31921–31929
  20. Marshall CJ. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular-signal-regulated kinase activation. Cell. 1995;80:179–185
  21. Traverse S, Gomez N, Paterson H, Marshall C, Cohen P. Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor. Biochem. J. 1992;288:351–355

PII: S0145-2126(02)00057-7

Leukemia Research
Volume 27, Issue 1 , Pages 51-56 , January 2003

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