Leukemia Research
Volume 26, Issue 10 , Pages 887-892 , October 2002

Clinical significance of IL-18 gene over-expression in AML

  • Bin Zhang

      Affiliations

    • Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Hematology, National Laboratory of Experimental Hematology, 288 Nanjing Road, Tianjin 300020, China
    • ,
  • Yong Wang

      Affiliations

    • Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Hematology, National Laboratory of Experimental Hematology, 288 Nanjing Road, Tianjin 300020, China
    • ,
  • Guo-Guang Zheng

      Affiliations

    • Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Hematology, National Laboratory of Experimental Hematology, 288 Nanjing Road, Tianjin 300020, China
    • ,
  • Xiao-Tong Ma

      Affiliations

    • Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Hematology, National Laboratory of Experimental Hematology, 288 Nanjing Road, Tianjin 300020, China
    • ,
  • Ge Li

      Affiliations

    • Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Hematology, National Laboratory of Experimental Hematology, 288 Nanjing Road, Tianjin 300020, China
    • ,
  • Feng-Kui Zhang

      Affiliations

    • Chinese Academy of Medical Sciences & Peking Union Medical College, Blood Diseases Hospital, Tianjin, China
    • ,
  • Ke-Fu Wu

      Affiliations

    • Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Hematology, National Laboratory of Experimental Hematology, 288 Nanjing Road, Tianjin 300020, China
    • Corresponding Author InformationCorresponding author. Tel.: +86-22-27230400; fax: +86-22-27306542

Received 23 October 2001 ,Accepted 11 January 2002.

References 

  1. Okamura H, Tsutsui H, Komastu T, Yutsudo M, Hakura A, Takimito T, et al.  Cloning of a new cytokine that induces IFN-γ production by T cells. Nature. 1995;378:88–91
  2. Okamura H, Tsutsui H, Kashiwamura S, Yoshimoto T, Nakanishi K. Regulation of interferon-γ production by IL-12 and IL-18. Curr Opin Immunol. 1998;10:259–264
  3. Gillespie MT, Horwood NJ. Interleukin-18: perspectives on the newest interleukin. Cytokine Growth Factor Rev. 1998;9:109–116
  4. Tsutsui H, Nakanishi K, Matsui K, Higasino K, Okamura H, Miyazzawa Y, et al.  IFN-γ inducing factor up-regulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones. J. Immunol. 1996;157:3967–3973
  5. Okamura H, Tsutsui H, Kashiwamura S, Yoshimoto T, Nakanishi K. Interleukin-18: a novel cytokine that augments both innate and acquired immunity. Adv Immunol. 1998;70:281–312
  6. Gu Y, Kuida K, Tsutsui H, Ku G, Hsiao K, Fleming MA, et al.  Activation of interferon-γ inducing factor mediated by interleukin-1β converting enzyme. Science. 1997;275:206–209
  7. Rothe H, Jenkins NA, Copeland NG, Kolb H. Active stage of auto-immune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2. J. Clin. Invest. 1997;99:469–474
  8. Olee T, Hashimoto S, Quach J, Lotz M. IL-18 is produced by articular chondrocytes and induces proinflammatory and catabolic responses. J. Immunol. 1999;162:1096–1100
  9. Bohn E, Sing A, Zumbihl R, Bielfeldt C, Okamura H, Kurimoto M, et al.  IL-18 (IFN-γ inducing factor) regulates early cytokine production in, and promotes resolution of bacterial infection in mice. J. Immunol. 1998;160:299–307
  10. Kawakami K, Qureshi MH, Zhang T, Okamura H, Kurimoto M, Saito A, et al.  IL-18 protects mice against pulmonary and disseminated infection with Cryptococcus neoformans by inducing IFN-γ production. J. Immunol. 1997;159:5528–5534
  11. Mastroeni P, Clare S, Khan S, Harrison JA, Hormaeche CE, Okamura H, et al.  IL-18 contributes to host resistance and γ interferon production in mice infected with virulent Salmanella typhimurium. Infect. Immunol. 1999;67:478–483
  12. Nakata A, Tsujimura T, Sugihara A, Okamura H, Iuasaki T, Shinkai K, et al.  Inhibition by interleukin-18 of osteolytic bone metastasis of human breast cancer cells. Anticancer Res. 1999;19:4131–4138
  13. Taniguchi M, Nagaoka K, Kunikata T, Kayano T, Ymauchi H, Nakamura S, et al.  Characterization of anti-human interleukin-18/interferon-γ inducing factor (IGIF) monoclonal antibodies and their application in the measurement of human IL-18 by ELISA. J Immunol Methods. 1997;206:107–113
  14. Wang Y, Li G, Zheng GG, Song YH, Wu KF. Detection and sequencing analysis of IL-18 expression in J6-1 leukemic cells. Leukemia Res. 2001;25:273–274
  15. Wu KF, Zheng YQ, Song YH, Feng BZ, Liu ZD, Bai JF. Establishment and characterization of human leukemia cell lines (J6-1, J6-2 and J6-3). Proc. CAMS PUMC. 1986;1:218–223
  16. Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, et al.  Proposed revised criteria for the classification of acute myeloid leukemia: a report of the French–American–British Cooperative Group. Ann. Intern. Med. 1985;103:620–625
  17. Wu KF, Rao Q, Zheng GG, Geng YQ, Li M, Kong J, et al.  Enhancement of J6-1 human leukemic cell proliferation by cell-cell contact: role of an M-CSF-like membrane-associated growth factor. Leukemia Res. 1994;18:843–849
  18. Wu KF, Rao Q, Zheng GG, He ZH, Ying HG, Song YH, et al.  Enhancement of J6-1 human leukemic cell proliferation by MAF-J6-1 through a cell–cell contact mechanism. II. Role of an M-CSF receptor-like membrane protein. Leukemia Res. 1998;22:55–60
  19. Fauth F, Weidmann E, Martin H, Schneider B, Sonnhoff S, Hoelzer D, et al.  AC133 expression on acute myeloid leukemia blasts: correlation to FAB and to CD34 expression and possible implications for peripheral blood progenitor cell purging in AML. Leukemia Res. 2001;25:191–196
  20. Geller RB, Zanurak M, Hurwitz CA, Berke PJ, Karp JE, Piantadosi S, et al.  Prognostic importance of immunophenotyoing in adults with acute myelocytic leukemia: the significance of the stem-cell glycoprotein CD34 (MY10). Br. J. Haematol. 1990;76:340–347
  21. Leith CP, Kopecky KJ, Godwin JE, McConnell T, Skovak M, Chen IM, et al.  Assessment of multi-drug resistance (MDR1) and cytogenetics distinguishes biologic subgroups. Blood. 1997;89:3323–3328
  22. Becker S, Quay J, Soukup J. Cytokine (tumor necrosis factor, IL-6 and IL-8) production by respiratory syncytical virus infected human alveolar macrophages. J. Immunol. 1991;147:4307–4312
  23. Zheng GG, Wu KF, Geng YQ, Kong J, Ayad A-K, Maria D, et al.  Expression of membrane-bound M-CSF in Hodgkin’s disease and other hematologic malignancies. Leukemia & Lymphoma. 1999;32:339–344
  24. Osaki T, Peron JM, Cai Q, Okamura A, Robbins PD, Kurimoto M, et al.  IFN-γ inducing factor/IL-18 administration mediates IFN-γ and IL-12-independent antitumor effects. J. Immunol. 1998;160:1742–1749
  25. Micallef MJ, Tanimoto T, Kohno K, Ikeda M, Kurimoto M. Interleukin-18 induces the sequential activation of natural killer cells and cytotoxic T lymphocytes to protect syngetic mice from transplantation with Meth A sarcoma. Cancer Res. 1997;57:4557–4563
  26. Takada H, Chga S, Mizuno Y, Suminoe A, Matsuzak A, Ihara K, et al.  Oversecretion of IL-18 in haemophagocytic lymphohistiocytosis: a novel marker of disease activity. Br. J. Haematol. 1999;106:182–189
  27. Fujimori Y, Takatsuka H, Takemoto Y, Hara H, Okamura H, Nakanishi K, et al.  Elevated interleukin (IL)-18 levels during acute graft-versus-host disease after allogenetic bone marrow transplantation. Br. J. Haematol. 2000;109:652–657
  28. Wang Y, Zhang B, Zheng GG, Wu KF. Characterization of interleukin-18 expression in human leukemia cell lines and hematological diseases. Exp. Hematol. 2001;29:56
  29. Takubo T, Kumora T, Nakao T, Nakamne H, Aoyama Y, Nishiki S, et al.  Comparative study on complete remission rate and overall survival in three groups classified based on the serum interleukin-18 level in non-Hodgkin’s lymphoma patients. Acta Haematol. 2000;104:220–222
  30. Drexler HG. Classification of acute myeloid leukemia: a comparison of FAB and immunophenotyping. Leukemia. 1987;1:697–705
  31. Dastugue N, Payen C, Lafage-Pochitaloff M, Bernard P, Leroux D, Huguet-Rigal F, et al.  Prognostic significance of karyotype in de novo adult acute myeloid leukemia. Leukemia. 1995;9:1491–1498
  32. Baer MR, Stewart CC, Lawrence D, Arthur DC, Mrozek K, Strout MP, et al.  Acute myeloid leukemia with 11q23 translocations: myelomonocytic immunophenotype by multiparameter flow cytometry. Leukemia. 1998;12:317–325
  33. Tang SS, Zheng GG, Wu KF, Chen GB, Liu HZ, Rao Q. Autocrine and possible intracrine regulation of HL-60 cell proliferation by macrophage colony-stimulating factor. Leukemia Res. 2001;25:1107–1114
  34. Cozzolino F, Rubartelli A, Alddinnucci D, Sitia R, Torcia M, Shaw A, et al.  Interleukin-1 as an autocrine growth factor for acute myeloid leukemia cells. Proc. Natl. Acad. Sci. USA. 1989;86:2369–2373
  35. Hoang T, Levy B, Onetto N, Haman A, Rodrigucz-Cimadevilla JC. Tumor necrosis factor α stimulates the growth of the clonogenic cells of acute myeloblastic leukemia in synergy with granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 1989;170:15–26
  36. Takubo T, Kumura T, Nakao T, Nakamae H, Aoyama Y, Kinoshita Y, et al.  Expression of human interleukin-18 antigen in leukemia cells of a patient with acute mixed lineage leukemia. Haematologia. 2001;31:69–71
  37. Lowenberg B, Putten WV, Touw IP, Delwel R, Santini V. Autonomous proliferation of leukemic cells in vitro as a determinant of prognosis in adult acute myeloid leukemia. New Engl J Med. 1993;328:614–619

PII: S0145-2126(02)00025-5

Leukemia Research
Volume 26, Issue 10 , Pages 887-892 , October 2002

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