Leukemia Research
Volume 26, Issue 8 , Pages 745-755, August 2002

Human B-cell lymphoma cell lines are highly sensitive to apoptosis induced by all-trans retinoic acid and interferon-γ

  • Nozomi Niitsu

      Affiliations

    • Department of Hematology and Internal Medicine IV, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara-shi, Kanagawa 228-8555, Japan
    • Saitama Cancer Center and Research Institute, Saitama, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-42-778-8111; fax: +81-42-778-9847
    • ,
  • Masaaki Higashihara

      Affiliations

    • Department of Hematology and Internal Medicine IV, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara-shi, Kanagawa 228-8555, Japan
    • ,
  • Yoshio Honma

      Affiliations

    • Saitama Cancer Center and Research Institute, Saitama, Japan

Received 11 September 2001; accepted 4 December 2001.

Abstract 

When cells were incubated in the presence of both interferon-γ (IFN-γ) and all-trans retinoic acid (ATRA), the concentration of IFN-γ required to induce apoptosis of B-cell lymphoma cells was much lower than that required for myeloid or erythroid cell lines. The concentration of IFN-γ that effectively inhibited the proliferation of BALM-3 cells was 1/40 of that required for BALM-1 cells. STAT-1 phosphorylation, IRF-1 mRNA and protein expression and RAR-β expression were enhanced to a greater degree in BALM-3 cells treated with IFN-γ and ATRA than in BALM-1 cells treated with IFN-γ and ATRA, suggesting that these IFN-γ related genes were involved in the induction of apoptosis of BALM-3 cells.

B-cell lymphoma, Interferon-γ, All-trans retinoic acid, Apoptosis

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PII: S0145-2126(01)00202-8

Leukemia Research
Volume 26, Issue 8 , Pages 745-755, August 2002

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