Lymphoid blastic crisis of chronic myelogenous leukaemia with inv(16)(p13;q22)

Tsuboi, Kazuya; Komatsu, Hirokazu; Miwa, Hiroshi; Iida, Shinsuke; Banno, Shogo; Wakita, Atsushi; Nitta, Masakazu; Ueda, Ryuzo

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Volume 26, Issue 8 , Pages 771-774, August 2002

Lymphoid blastic crisis of chronic myelogenous leukaemia with inv(16)(p13;q22)

Kazuya Tsuboi
- Second Department of Internal Medicine, Nagoya City University Medical School, Mizuho-ku, Nagoya 467-8601, Japan
- Department of Internal Medicine, Division of Haematology, Aichi Medical University, Nagakute-cho, Aichi-gun, Aichi 480-1195, Japan
- Corresponding author. Tel.: +81-561-62-3311; fax: +81-561-63-3401
Hirokazu Komatsu
- Second Department of Internal Medicine, Nagoya City University Medical School, Mizuho-ku, Nagoya 467-8601, Japan
Hiroshi Miwa
- Department of Internal Medicine, Division of Haematology, Aichi Medical University, Nagakute-cho, Aichi-gun, Aichi 480-1195, Japan
Shinsuke Iida
- Second Department of Internal Medicine, Nagoya City University Medical School, Mizuho-ku, Nagoya 467-8601, Japan
Shogo Banno
- Second Department of Internal Medicine, Nagoya City University Medical School, Mizuho-ku, Nagoya 467-8601, Japan
Atsushi Wakita
- Second Department of Internal Medicine, Nagoya City University Medical School, Mizuho-ku, Nagoya 467-8601, Japan
Masakazu Nitta
- Department of Internal Medicine, Division of Haematology, Aichi Medical University, Nagakute-cho, Aichi-gun, Aichi 480-1195, Japan
Ryuzo Ueda
- Second Department of Internal Medicine, Nagoya City University Medical School, Mizuho-ku, Nagoya 467-8601, Japan

Received 20 September 2001; accepted 1 November 2001.

Abstract

We report a case of chronic myelogeneous leukaemia (CML) in B-lineage lymphoid blastic crisis (BC) having chromosome abnormality, inv(16)(p13;q22) in addition to Philadelphia chromosome, in 20/20 marrow metaphase. Inv(16)(p13;q22) was not observed in cells of chronic phase or accelerate phase. Abnormalities of chromosome 16, including inv(16)(p13;q22), del(16)(q22) and t(16;16)(p13;q22), have been reported mostly in acute myelomonocytic leukaemia (AML), (FAB M4-Eo), and some in CML–BC and myelodysplastic syndrome (MDS) cases. Most of the cases showed increase of myelomonocytic components and abnormal eosinophils with dysplastic granules in the bone marrow (BM). However, our case was diagnosed as lymphoid BC without increase of myelomonocytic components, although some abnormal eosinophilia was seen. To date, lymphoid BC of CML having inv(16)(p13;q22) abnormality has not been reported. The case presented here could be a clue to understand the pathophysiology of inv(16)(p13;q22) leukaemia.

Lymphoid crisis, CML, Inv(16)