Leukemia Research
Volume 26, Issue 3 , Pages 241-248, March 2002

High serum soluble CD44 is correlated with a poor outcome of aggressive non-Hodgkin's lymphoma

  • Nozomi Niitsu

      Affiliations

    • Department of Hematology and Internal Medicine, Internal Medicin IV, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara-Shi, Kanagawa 228-8555, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-42-778-8811; Fax: +81-42-778-9847
    • ,
  • Kimiko Iijima

      Affiliations

    • First Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan

Received 20 February 2001; accepted 25 June 2001.

Abstract 

We measured soluble CD44 (sCD44) by enzyme-linked immunosorbent assay in 216 patients with non-Hodgkin's lymphoma (NHL). The sCD44 level was significantly elevated in patients with NHL. A sCD44 level of ≥500 ng/ml showed a significantly decreased overall survival (OS) rate and progression free survival (PFS) rate. In the high–intermediate+high risk group (international prognostic index (IPI)), both the OS rate and the PFS rate were significantly decreased when the sCD44 level was ≥1000 ng/ml. Moreover, the results of a multivariate analysis showed that the five IPI prognostic factors and the sCD44 level were independent prognostic factors, thus suggesting that sCD44 levels could be a useful prognostic marker for aggressive lymphoma

Keywords:  Non-Hodgkin's lymphoma, Soluble CD44, Prognostic factor, International prognostic index

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PII: S0145-2126(01)00122-9

Leukemia Research
Volume 26, Issue 3 , Pages 241-248, March 2002

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