Leukemia Research
Volume 26, Issue 3 , Pages 235-240, March 2002

Primary myelodysplastic syndrome with normal cytogenetics: utility of ‘FISH panel testing’ and M-FISH

Department of Laboratory Medicine and Pathology, Mayo Clinic/Foundation, 200 First Street S.W., Rochester, MN 55905, USA

Received 19 February 2001; accepted 10 June 2001.

Abstract 

The myelodysplastic syndromes (MDS) are a clinically heterogeneous group of hematologic disorders. Cytogenetic analysis is crucial as it can provide both diagnostic and prognostic information. Herein, 32 cytogenetically normal patients with primary MDS were analyzed both by multiple FISH probes on interphase nuclei (FISH panel testing) and by M-FISH (metaphase nuclei). One patient had a chromosome 13q-arm deletion, while the remaining 31 patients had normal results. These findings confirm standard cytogenetics as an excellent technique in identifying the common chromosomal abnormalities associated with MDS and suggest limited utility for either a FISH panel test or M-FISH in primary MDS.

Keywords:  FISH, Myelodysplastic syndrome, Cytogenetics, M-FISH, Chromosome, Hematology

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0145-2126(01)00117-5

Leukemia Research
Volume 26, Issue 3 , Pages 235-240, March 2002

Article Tools

* Image Usage & Resolution