Leukemia Research
Volume 25, Issue 12 , Pages 1085-1088 , December 2001

Quantitative, real-time polymerase chain reactions for FLT3 internal tandem duplications are highly sensitive and specific

  • Derek L. Stirewalt

      Affiliations

    • Program in Genetics and Genomics, Clinical Research Division, Fred Hutchinson Cancer Research Center, D4-100, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    • Division of Oncology, University of Washington, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-206-667-5113; fax: +1-206-667-2917
    • ,
  • Cheryl L. Willman

      Affiliations

    • Southwest Oncology Group Leukemia Biology Committee, San Antonio, TX 78245, USA
    • Department of Pathology and Cell Biology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    • ,
  • Jerald P. Radich

      Affiliations

    • Program in Genetics and Genomics, Clinical Research Division, Fred Hutchinson Cancer Research Center, D4-100, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    • Division of Oncology, University of Washington, USA
    • Southwest Oncology Group Leukemia Biology Committee, San Antonio, TX 78245, USA

Received 20 February 2001 ,Accepted 20 April 2001.

References 

  1. Radich JP. Clinical applicability of the evaluation of minimal residual disease in acute leukemia. Curr Opin Oncol. 2000;12:36
  2. Dastugue N, Payen C, Lafage-Pochitaloff M, et al.  Prognostic significance of karyotype in de novo adult acute myeloid leukemia. The BGMT group. Leukemia. 1995;9:1491
  3. Kiyoi H, Naoe T, Nakano Y, et al.  Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia. Blood. 1999;93:3074
  4. Stirewalt DL, Kopecky KJ, Meshinchi S, et al.  FLT3, ras, and p53 mutations in elderly patients with acute myeloid leukemia. Blood. 2001;97:3589
  5. Rajyalakshmi L, McBride JA, Cabanillas F, et al.  Novel 5′ exonuclease-based real-time pcr assay for the detection of t(14;18)(q32;q21) in patients with follicular lymphoma. Am J Path. 1998;153:63
  6. Brisco MJ, Condon J, Hughes E, et al.  Outcome prediction in childhood acute lymphoblastic leukaemia by molecular quantification of residual disease at the end of induction. Lancet. 1994;343:196
  7. Nakano Y, Kiyoi H, Miyawaki S, et al.  Molecular evolution of acute myeloid leukaemia in relapse: unstable N-ras and FLT3 genes compared with p53 gene. Br J Haematol. 1999;104:659
  8. Radich JP, Gehly G, Gooley T, et al.  Polymerase chain reaction detection of the bcr-abl fusion transcript after allogeneic marrow transplantation for chronic myeloid leukemia: results and implications in 346 patients. Blood. 1995;85:2632

PII: S0145-2126(01)00087-X

Leukemia Research
Volume 25, Issue 12 , Pages 1085-1088 , December 2001

Article Tools

* Image Usage & Resolution