Leukemia Research
Volume 25, Issue 12 , Pages 1115-1125 , December 2001

Direct effect of bispecific anti-CD33×anti-CD64 antibody on proliferation and signaling in myeloid cells

  • Larisa Balaian

      Affiliations

    • Department of Medicine and Cancer Center, University of California, San Diego School of Medicine, La Jolla, CA, USA
    • ,
  • Edward D. Ball

      Affiliations

    • Blood and Marrow Transplantation Division, University of California, 9500 Gilman Drive, San Diego, La Jolla, CA 92093-0960, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-858-657-7053; fax: +1-858-657-6837

Received 22 January 2001 ,Accepted 27 April 2001.

References 

  1. Griffin JD, Linch D, Sabbath K, Larcom P, Schlossman SF. A monoclonal antibody reactive with normal and leukemic human myeloid progenitor cells. Leuk. Res. 1984;8:521
  2. Ball ED, McDermott JM, Griffin JD, Davey FR, Davis R, Bloomfield CD. Expression of the three myeloid cell-associated immunoglobulin G Fc receptors defined by murine monoclonal antibodies on normal bone marrow and acute leukemia cells. Blood. 1989;73:1951
  3. Ball ED. Immunophenotyping of acute myeloid leukemia cells. Clin. Lab. Med. 1990;110:721
  4. Applebaum FR. Antibody-targeted therapy for myeloid leukemia. Semin. Hematol. 1999;36:2
  5. Fanger MW, Morganelli PM, Guyre PM. Bispecific antibodies. Crit. Rev. Immunol. 1992;12:101
  6. Chen J, Zhou JH, Ball ED. Monocyte-mediated lysis of acute myeloid leukemia cells in the presence of the bisspecific antibody 251x22 (anti-CD33×anti-CD64). Clin. Cancer Res. 1995;1:319
  7. Glennie MY, McBride HM, Worth AT, Stevenson GT. Preparation and performance of bispecific F(ab′gamma)2 antibody containing thioether linked Fab′ gamma ftagments. J. Immunol. 1987;139:2367
  8. Ball ED, Guyre PM, Mills L, Fisher J, Dinces NB, Fanger MW. Initial trial of bispecific antibody-mediated immunotherapy of CD15-bearing tumors: cytotoxicity of human tumor cells using a bispecific antibody comprised of anti-CD15 (MoAb PM81) and anti-CD64/Fc-gamma RI (MoAb32). J. Hematother. 1992;1:85
  9. Silla LM, Chen J, Zhong RK, Whiteside TM, Ball ED. Potentiation of lysis of leukemia cells by a bispecific aantibody to CD33 and CD16 (Fc gamma RIII) expressed by human natural killer (NK) cells. Br. J. Haematol. 1995;89:712
  10. Cambier JC. Antigen and Fc receptor signaling. The awesome power of the immunoreceptor tyrosine-based activation motif (ITAM). J. Immunol. 1995;155:3281
  11. Duchemin AM, Ernst LK, Anderson CL. Clustering of the high affinity Fc receptor for immunoglobulin G (Fc gamma RI) results in phosphorylation of its associated gamma chain. J. Biol. Chem. 1994;269:12111
  12. Indik ZK, Park JG, Hunter S, Schreiber AD. The molecular dissection of Fc gamma receptor mediated phagocytosis. Blood. 1995;86:4389
  13. Wang AV, Scholl PR, Geha RS. Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn. J. Exp. Med. 1994;180:1165
  14. Pan XQ, Darby C, Indik ZK, Schreiber AD. Activation of three classes of nonreceptor tyrosine kinases following Fc gamma receptor crosslinking in human monocytes. Clin. Immunol. 1999;90:55
  15. Kiener PA, Rankin BM, Burkhardt AL, Shieven GL, Gilliard LK, Rowley RB, et al. Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activated a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase. J. Biol. Chem. 1993;268:24442
  16. Taylor A, Jahn T, Smith S, Lamkin T, Uribe L, Liu J, et al. Differential activation of the tyrosine kinases ZAP-70 and Syk after Fc gamma RI stimulation. Blood. 1997;87:388
  17. Marcilla A, Rivero-Lezcano OM, Agarwal A, Robbins KC. Identification of the major tyrosine kinase substrate in signaling complexes formed after engagement of Fc gamma receptor. J. Biol. Chem. 1995;270:9115
  18. Brizzi MF, Rosso A, Dentelli P, Ferrero D, Lanfancne L, Pegoraro L. C-Cbl tyrosine phosphorylation and subcellular localization in human primary leukemia cells. Exp. Hemat. 1998;26:1228
  19. Liao F, Shin HS, Rhee SG. Tyrosine phosphorylation of phospholipase C-gamma induced by cross-linking of the high-affinity Fc receptor for IgG in U-937 cells. Proc. Natl. Acad. Sci. USA. 1992;89:3659
  20. Fanger NA, Cosman D, Peterson L, Braddy SC, Maliszewski CR, Borges L. The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes. Eur. J. Immunol. 1998;28:3423
  21. Ulyanova T, Blasioli J, Woodford-Thomas TA, Thomas ML. The sialoadhesin CD33 is a myeloid-specific inhibitory receptor. Eur. J. Immunol. 1999;29:3440
  22. Taylor VC, Buckley CD, Douglas M, Cody AJ, Simmons DL, Freeman SD. The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein tyrosine phosphatases, SHP-1 and SHP-2. J. Biol. Chem. 1999;274:11505
  23. Paul SP, Taylor LS, Stansbury EK, McVicar DW. Myeloid specific human CD33 is an inhibitory receptor with differential ITIM function in recruiting the phosphatases SHP-1 and SHP-2. Blood. 2000;96:483
  24. Edelson PJ, Cohn ZA. Purification and cultivation of monocytes and macrophages. In:  Bloom BA,  David JR editor. In vitro Methods in Cell-mediated and Tumor Immunity. San Diego, CA: Academic Press; 1976;p. 333
  25. Pike BL, Robinson WA. Human bone marrow colony growth in agar gel. J. Cell. Physiol. 1970;78:77
  26. Vitale C, Romagnani C, Falco M, Ponte M, Vitale M, Moretta A, et al. Engagement of p75/AIRMI or CD33 inhibits the proliferation of normal or leukemic myeloid cells. Proc. Natl. Acad. Sci. USA. 1999;96:15091
  27. Ferlazzo G, Spaggiari GM, Semino C, Melioli G, Moretta L. Engagement of CD33 surface molecules prevents the generation of dendritic cells from both monocytes and CD34+ myeloid precursors. Eur. J. Immunol. 2000;30:827
  28. Strzelecka A, Kwiatkowska K, Sobota A. Tyrosine phosphorylation and Fc gamma receptor-mediated phagocytosis. FEBS Lett. 1997;400:11
  29. Ravetch JV, Kinet JP. Fc receptors. Annu. Rev. Immunol. 1991;9:457
  30. Brooks D, Ravetch JV. Fc receptor signaling. Adv. Exp. Med. Biol. 1994;365:185
  31. Crowley MT, Costello PS, Fitzer-Attas CJ, Turnre M, Meng F, Lowell C, et al. A critical role for Syk in signal tranduction and phagocytosis mediated by Fcγ receptors in macrophages. J. Exp. Med. 1997;186:1027
  32. Kiefer F, Brumell J, Al-Alawi N, Latour S, Cheng A, Veillette A, et al. The Syk protein tyrosine kinase is essential for Fc gamma receptor signaling in macrophages and neutrophils. Mol. Cell. Biol. 1998;18:4209
  33. Ravetch JV. Fc receptors:rubor redux. Cell. 1994;78:553
  34. Park RK, Kyono WT, Liu Y, Durden DL. Cbl–Crb2 interaction in myeloid immunoreceptor tyrosine activation motif signaling. J. Immunol. 1998;160:5018
  35. Erdreich-Epstein A, Liu M, Kant AM, Izadi KD, Nolta JA, Durden DL. Cbl functions downstream of Src kinases in Fc gamma RI signaling in primary human macrophages. J. Leukoc. Biol. 1999;65:523
  36. Pawson T. Protein modules and signaling networks. Nature. 1995;373:573
  37. Boyle WJ. Growth factors and tyrosine kinase receptors during development and cancer. Curr. Opin. Oncol. 1992;4:156
  38. Shannon K. The Ras signaling pathway and the molecular basis of myeloid leukemogenesis. Curr. Opin. Hemat. 1995;2:305
  39. Zanke B, Squire J, Griesser H, Henry M, Suzuki H, Patterson B, et al. A hematopoietic protein tyrosine phosphatase (HePTP) gene that is amplified and overexpressed in myeloid malignancies maps to chromosome 1q32.1. Leukemia. 1994;8:236
  40. Sievers EL. Targeted therapy of acute myeloid leukemia with monoclonal antibodies and immunoconjugates. Cancer Chemother. Pharmacol. 2000;46(Suppl.):S18
  41. Caron PC, Lai LT, Scheinberg DA. Interleukin-2 enhancement of cytotoxicity by humanized monoclonal antibody M195 (anti-CD33) in myelogenous leukemia. Clin. Cancer Res. 1995;1:63

PII: S0145-2126(01)00084-4

Leukemia Research
Volume 25, Issue 12 , Pages 1115-1125 , December 2001

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