Leukemia Research
Volume 25, Issue 12 , Pages 1075-1083 , December 2001

Oligoclonal T cell expansion in myelodysplastic syndrome: evidence for an autoimmune process

Received 9 January 2001 ,Accepted 30 April 2001.

References 

  1. Raza A, Mundle S, Shetty V, Alvi S, Chopra H, Span L, et al. Novel insights into the biology of myelodysplastic syndrome: excessive apoptosis and the role of cytokines. Int. J. Hematol. 1996;63:265
  2. Barrett J, Saunthararajah Y, Molldrem J. Myelodysplastic syndrome and aplastic anemia; distinct entities or disease linked by a common pathophysiology?. Semin. Hematol. 2000;37:15
  3. Hamblin TJ. Immunological abnormalities in myelodysplastic syndromes. Semin. Hematol. 1996;33:150
  4. Saunthararajah Y, Molldrem J, Rivera M, Williams A, Stetler-Stevenson M, Sorbara L, Young NS, Barrett JA. Coincident Myelodysplastic Syndrome and T-cell Large Granular Lymphocytic Disease: Clinical and Pathophysiological Features, Br J Haematol, in press.
  5. Smith MA, Smith JG. The occurrence subtype and significance of haemopoietic inhibitory T cells (HIT cells) in myelodysplasia: an in vitro study. Leuk. Res. 1991;15:597
  6. Sugawara T, Endo K, Shishido T, Sato A, Kameoka J, Fukuhara O, et al. T-cell mediated inhibition of erythropoiesis in myelodysplastic syndromes. Am. J. Hematol. 1992;41:304
  7. Molldrem JJ, Jiang YZ, Stetler-Stevenson MA, Mavroudis D, Hensel N, Barrett AJ. Haematological response of patients with myelodysplastic syndrome to antithymocyte globulin is associated wit a loss of lymphocyte-mediated inhibition of CFU-GM and alterations in T-cell receptor V beta profiles. Br. J. Haematol. 1998;102:1314
  8. Molldrem JJ, Caples M, Mavroudis D, Plante M, Young NS, Barrett Al. Antithymocyte globulin for patients with myelodysplastic syndrome. Br. J. Haematol. 1997;99:699
  9. Jonasova A, Neuwirtova R, Cermak J, Vozobulova V, Mocikova K, Siskova M, et al. Cyclosporine A therapy in hypoplastic MDS patients and certain refractory anaemias without hypoplastic bone marrow. Br. J. Haematol. 1998;100:304
  10. Maslanka K, Piatek T, Gorski J, Yassai M, Gorski J. Molecular analysis of T cell repertoires: spectratypes generated by multiplex polymerase chain reaction and evaluated by radioactivity or fluorescence. Hum. Immunol. 1995;44:28
  11. Yassai M, Naumova E, Gorski J. Generation of TCR spectratypes by multiplex PCR for T cell repertoire analysis. In:  Oksenberg JR editors. The antigen T cell receptor: selected protocols and applications.. New York: Chapman & Hall; 1997;p. 326
  12. Genevee C, Diu A, Nierat J, Caignard A, Dietrich PY, Ferradini L, et al. An experimentally validated panel of subfamily-specific oligonucleotide primers (V alpha 1-w29/V beta 1-w24) for the study of human T cell receptor variable V gene segment usage by PCR. Eur. J. Immunol. 1992;22:1261
  13. Hawes GE, Struyk L, Van den Elsen PJ. Differential usage of T cell receptor V gene segments in CD4+ and CD8+ subsets of T lymphocytes in monozygotic twins. J. Immunol. 1993;150:2033
  14. Even J, Lim A, Puisieux I, Ferradini L, Dietrich PY, Toubert A, et al. T-cell repertoires in healthy and diseased human tissues analysed by T-cell receptor β-chain CDR3 size determination: evidence for oligoclonal expansions in tumors and inflammatory diseases. Res. Immunol. 2001;112:195–200
  15. Clark DM, Lampert I. A apoptosis is a common histopathological finding in myelodysplasia; the correlate of ineffective hematopoiesis. Leuk. Lymphoma. 1990;2:415
  16. Gersuk GM, Beckham C, Loken MR, Kiener P, Anderson JE, Farrand A, et al. A role for tumor necrosis factor-alpha, Fas and Fas-ligand in marrow failure associated with myelodysplastic syndrome. Br. J. Haematol. 1998;103:176
  17. Kitagawa M, Saito I, Kuwata T, Yoshida S, Yamaguchi S, Takahashi M, et al. Overexpression of tumor necrosis factor (ThW)-alpha and interferon (IFN)-gamma by bone marrow cells from patients with myelodysplastic syndromes. Leukemia. 1997;11:2049
  18. Young NS, Maciejewski J. The pathophysiology of acquired aplastic anemia. New Engl. J. Med. 1997;336:1365
  19. Schwab R, Szabo P, Manavalan JS, Weksler ME, Posnett DN, Pannetier C, et al. Expanded CD4+ and CD8+ T cell clones in elderly humans. J. Immunol. 1997;158:4493
  20. Wack A, Cossarizza A, Heltai S, Barbieri D, D'Addato S, Fransceschi C, et al. Age-related modifications of the human T cell repertoire due to differential clonal expansions in the CD4+ and CD8+ subsets. Int. Immunol. 1998;10:1281
  21. Raza A. Hypothesis: myelodysplastic syndromes may have a viral etiology. Int. J. Hematol. 1998;68:245
  22. Zeng W, Nakao S, Takamatsu H, Yachie A, Takami A, Kondo Y, et al. Characterization of T-cell repertoire of the bone marrow in immune-mediated aplastic anemia: evidence for the involvement of antigen-driven T-cell response in cyclosporine-dependent aplastic anemia. Blood. 1999;93:3008
  23. Saunthararajah Y, Nakamura R, Robyn J, Loberiza F, Brown K, Young NS, et al. HLA DR15 (DR2) is over-presented in myelodysplastic syndrome (MDS) and is associated with a response to immunosuppression [Abstract]. Blood. 2000;96:546a

PII: S0145-2126(01)00083-2

Leukemia Research
Volume 25, Issue 12 , Pages 1075-1083 , December 2001

Article Tools

* Image Usage & Resolution