Leukemia Research
Volume 25, Issue 12 , Pages 1059-1065 , December 2001

Novel T-cell receptor δ gene rearrangement involving a recombining element located 2.6 kb 3′ from the Vδ2 gene segment

  • G.K. Przybylski

      Affiliations

    • HU Berlin, UKRV, Abt. Hämatologie, Berlin, Germany
    • Institute of Human Genetics, Polish Academy of Sciences, Pozna, Poland
    • ,
  • H. Oettle

      Affiliations

    • HU Berlin, UKRV, Abt. Hämatologie, Berlin, Germany
    • ,
  • W. Siegert

      Affiliations

    • HU Berlin, UKRV, Abt. Hämatologie, Berlin, Germany
    • ,
  • C.A. Schmidt

      Affiliations

    • HU Berlin, UKRV, Abt. Hämatologie, Berlin, Germany
    • Corresponding Author InformationCorresponding author. Present address: Humboldt Universität Berlin, Charite Campus Virchow-Klinikum, Abt. Hämatologie und Onkologie, Mitelallee 11, Augustenburger Platz 1, 13353 Berlin, Germany. Tel.: +49-30-45055-3663; fax: +49-30-45055-3925

References 

  1. Loh EY, Lanier LL, Turck CW, Littman DR, Davis MM, Chien YH, et al.  Identification and sequence of a fourth human T cell antigen receptor chain. Nature. 1987;330:569–572
  2. Isobe M, Russo G, Haluska FG, Croce CM. Cloning of the gene encoding the δ subunit of the human T-cell receptor reveals its physical organization within the α-subunit locus and its involvement in chromosome translocations in T-cell malignancy. Proc Natl Acad Sci. 1988;85:3933–3937
  3. Takihara Y, Tkachuk D, Michalopoulos E, Champagne E, Reimann J, Minden M, et al.  Sequence and organization of the diversity, joining, and constant region genes of the humans T-cell δ-chain locus. Proc Natl Acad Sci. 1988;85:6097–6101
  4. Satyanarayana K, Hata S, Devlin P, Roncarola MG, De Vries JE, Spits H, et al.  Genomic organization of the human T-cell antigen-receptor α/δ locus. Proc Natl Acad Sci. 1988;85:8166–8170
  5. Loh EY, Cwirla S, Serafini AT, Philips JH, Lanier LL. Human T-cell-receptor δ chain. Genomic organization, diversity, and expression in populations of cells. Proc Natl Acad Sci. 1988;85:9714–9718
  6. Takihara Y, Reimann J, Michalopoulos E, Ciccone E, Moretta L, Mak TW. Diversity and structure of human T cell receptor δ chain genes in peripheral blood α/δ-bearing T lymphocytes. J Exp Med. 1989;169:393–405
  7. Havran WL, Allison JP. Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors. Nature. 1988;335:443–445
  8. Moretta L, Ciccone E, Ferrini S, Pelicci PG, Mingari MC, Zeromski J, et al.  Molecular and cellular analysis of human T lymphocytes expressing α/δ T-cell receptor. Immunol Rev. 1991;120:117–135
  9. Alt FW, Blackwell TK, DePinho RA, Reth MG, Yancopoulos GD. Regulation of genome rearrangement events during lymphocytic differentiation. Immunol Rev. 1986;89:5–30
  10. Dyer MJS. T-cell receptor δ/α rearrangements in lymphoid neoplasms. Blood. 1989;74:1073–1083
  11. Asou N, Hattori T, Matsuoka M, Kawano F, Takatsuki K. Rearrangements of T-cell antigen receptor δ chain gene in hematologic neoplasms. Blood. 1989;74:2707–2712
  12. Hara J, Kawa-Ha K, Takihara Y, Yumura-Yagi K, Ishihara S, Tawa A, et al.  Developmental process of the T-cell receptor α and δ gene assembly in B-cell precursor acute lymphoblastic leukaemia. Br J Haematol. 1991;78:180–186
  13. Davodeau F, Peyrat MA, Hallet MM, Vie H, Bonneville M. Characterization of a new functional TCR Jδ segment in humans. Evidence for a marked conservation of Jδ sequences between humans, mice, and sheep. J Immunol. 1994;153:137–142
  14. Breit TM, Wolvers-Tettero ILM, Beishuizen A, Verhoeven MAJ, van Wering ER, van Dongen JJM. Southern blot patterns, frequencies, and junctional diversity of T-cell receptor-δ gene rearrangements in acute lymphoblastic leukemia. Blood. 1993;82:3063–3074
  15. Chien YH, Iwashima M, Wettstein DA, Kaplan KB, Elliott JF, Born W, et al.  T-cell receptor δ gene rearrangements in early thymocytes. Nature. 1987;330:722–727
  16. Lindsten T, Fowlkes BJ, Samelson LE, Davis MM, Chien YH. Transient rearrangements of the T cell antigen receptor α locus in early thymocytes. J Exp Med. 1987;166:761–775
  17. Hata S, Satyanatrayana K, Devlin P, Band H, McLean J, Strominger JL, et al.  Extensive junctional diversity of rearranged human T cell receptor δ genes. Science. 1988;240:1544–1551
  18. Biondi A, Champagne E, Rossi V, Giudici G, Cantu-Rajnoldi A, Masera G, et al.  T-cell receptor δ gene rearrangement in childhood T-cell acute lymphoblastic leukemia. Blood. 1989;73:2133–2138
  19. Biondi A, diCelle PF, Rossi V, Casorati G, Matullo G, Giudici G, et al.  High prevalence of T-cell receptor Vδ2-(D)-Dδ3 or Dδ1/2-Dδ3 rearrangements in B-precursor acute lymphoblastic leukemias. Blood. 1990;75:1834–1840
  20. Fontenay M, Flandrin G, Baurman H, Loiseau P, Valensi F, Daniel M-T, et al.  T cell receptor δ gene rearrangements occur predominantly in immature myeloid leukemias exhibiting lineage promiscuity. Leukemia. 1990;4:100–105
  21. Yumura-Yagi K, Hara J, Kurahashi H, Okamura J, Koizumi S, Toyoda Y, et al.  Clinical significance of CD/7-positive stem cell leukemia. A distinct subtype of mixed lineage leukemia. Cancer. 1991;68:2273–2280
  22. Adriaansen HJ, Soeting PWC, Wolvers-Tettero ILM, van Dongen JJM. Immunoglobulin and T-cell receptor gene rearrangements in acute non-lymphocytic leukemias. Analysis of 54 cases and a review of the literature. Leukemia. 1991;5:744–751
  23. Schmidt CA, Oettle H, Neubauer A, Seeger K, Thiel E, Huhn D, et al.  Rearrangements of T-cell receptor δ, γ and β genes in acute myeloid leukemia coexpressing T-lymphoid features. Leukemia. 1992;6:1263–1267
  24. Przybylski G, Oettle H, Ludwig WD, Siegert W, Schmidt CA. Molecular Characterization of illegitimate TCRδ gene rearrangements in acute myeloid leukemia. Br J Haematol. 1994;87:301–307
  25. Schmidt CA, Przybylski G, Tietze A, Oettle H, Siegert W, Ludwig WD. Acute myeloid and T-cell acute lymphoblastic leukaemia with aberrant antigen expression exhibit similar TCRδ gene rearrangements. Br J Haematol. 1996;92:929–936
  26. Boehm T, Baer R, Lavenir I, Forster A, Waters JJ, Nacheva E, et al.  The mechanism of chromosomal translocation t(11;14) involving the T-cell receptor Cδ locus on human chromosome 14q11 and a transcribed region of chromosome 11p15. Embo J. 1988;7:385–394
  27. Yokota S, Hansen-Hagge TE, Ludwig WD, Reiter A, Raghavachar A, Kleihauer E, et al.  Use of polymerase chain reaction to monitor minimal residual disease in acute lymphoblastic leukemia patients. Blood. 1991;77:331–339
  28. Saiki RK, Gelfand DH, Stoffel S, Scharf SJ, Higuchi R, Horn GT, et al.  Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science. 1988;239:487–491
  29. Schmidt CA, Przybylski G, Oettle H, Seeger KH, Ludwig WD, Siegert W. Heterogeneity of Vδ2 TCRδ gene rearrangements in acute myeloid leukemia. Leuk Lymphoma. 1994;16:73–77
  30. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ. Basic local alignment search tool. J Mol Biol. 1990;215:403–410
  31. Boysen C, Simon MI, Hood L. Analysis of the 1.1-Mb human α/δ T-cell receptor locus with bacterial artifical chromosome clones. Genome Res. 1997;7:330–338
  32. Tonegawa S. Somatic generation of antibody diversity. Nature. 1983;302:575–581
  33. Hesse JE, Lieber MR, Mizuuchi K, Gellert M. V(D)J recombination: a functional definition of of the joining signals. Genes Dev. 1989;3:1053–1061
  34. Ramsden DA, Baetz K, Wu GE. Conservation of sequence in recombination signal sequence spacers. Nucleic Acids Res. 1994;22:1785–1796
  35. De Villartay J-P, Hockett RD, Coran D, Korsmeyer SJ, Cohen DI. Deletion of the human T-cell receptor δ-gene by a site-specific recombination. Nature. 1988;335:170–174
  36. Hocket RD, Villartay J-P, Pollock K, Poplack DG, Cohen DI, Korsmeyer SJ. Human T-cell antigen receptor (TCR) δ-chain locus and elements responsible for its deletion are within the TCR α-chain locus. Proc Natl Acad Sci. 1988;85:9694–9698
  37. Hara J, Takihara Y, Yumura-Yagi K, Ishihara S, Tawa A, Mak TW, et al.  Differential usage of δ recombining element and Vδ genes during T-cell ontogeny. Blood. 1991;78:20752081
  38. Verschuren MCM, Wolvers-Tettero ILM, Breit TM, Noordzij J, van Wering ER, van Dongen JJM. Preferential rearrangements of the T cell receptor-δ-deleting elements in human T cells. J Immunol. 1997;158:1208–1216

PII: S0145-2126(01)00081-9

Leukemia Research
Volume 25, Issue 12 , Pages 1059-1065 , December 2001

Article Tools

* Image Usage & Resolution