Leukemia Research
Volume 25, Issue 12 , Pages 1089-1094 , December 2001

Extramedullary T lymphoid blast crisis representing an additional translocation, t(6;8)(q25;q22) in a patient with Philadelphia-positive chronic myelogenous leukemia after allogeneic bone marrow transplantation

  • Kiyoshi Okazuka

      Affiliations

    • First Department of Internal Medicine, Niigata University School of Medicine, Asahimachi-dori 1, Niigata City 951-8520, Japan
    • ,
  • Ken Toba

      Affiliations

    • First Department of Internal Medicine, Niigata University School of Medicine, Asahimachi-dori 1, Niigata City 951-8520, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-25-2272185; fax: +81-25-2270774
    • ,
  • Kazuhiro Kawai

      Affiliations

    • Department of Dermatology, Niigata University School of Medicine, Asahimachi-dori 1, Niigata City 951-8520, Japan
    • ,
  • Koji Nikkuni

      Affiliations

    • First Department of Internal Medicine, Niigata University School of Medicine, Asahimachi-dori 1, Niigata City 951-8520, Japan
    • ,
  • Junjiro Tsuchiyama

      Affiliations

    • First Department of Internal Medicine, Niigata University School of Medicine, Asahimachi-dori 1, Niigata City 951-8520, Japan
    • ,
  • Akihito Momoi

      Affiliations

    • First Department of Internal Medicine, Niigata University School of Medicine, Asahimachi-dori 1, Niigata City 951-8520, Japan
    • ,
  • Naoko Kanazawa

      Affiliations

    • First Department of Internal Medicine, Niigata University School of Medicine, Asahimachi-dori 1, Niigata City 951-8520, Japan
    • ,
  • Koich Nagai

      Affiliations

    • Department of Internal Medicine, Niigata Prefectural Central Hospital, Joetsu City, Japan
    • ,
  • Noriatsu Suzuki

      Affiliations

    • Department of Internal Medicine, Niigata Prefectural Central Hospital, Joetsu City, Japan
    • ,
  • Yoshifusa Aizawa

      Affiliations

    • First Department of Internal Medicine, Niigata University School of Medicine, Asahimachi-dori 1, Niigata City 951-8520, Japan

Received 8 January 2001 ,Accepted 5 April 2001.

References 

  1. Hernandez P, Carnot J, Cruz C. Chronic myeloid leukaemia blast crisis with T-cell features. Br. J. Haematol. 1982;51:175–177
  2. Palutke M, Eisenberg L, Nathan L. Ph1-positive T lymphoblastic transformation of chronic granulocytic leukaemia in a lymphnode. Lancet. 1982;6:1053
  3. Griffin JD, Tantravahi R, Canellos GP, Wisch JS, Reinherz EL, Sherwood G, et al.  T-cell surface antigens in a patient with blast crisis of chronic myeloid leukemia. Blood. 1983;61:640–643
  4. Herrmann F, Komischke B, Kolecki P, Ludwig WD, Sieber G, Teichmann H, et al.  Ph1(+) positive blast crisis of chronic myelogenous leukaemia exhibiting features characteristic of early T blasts. Scand. J. Haematol. 1984;32:411–416
  5. Jacobs P, Greaves M. Ph1-positive T lymphoblastic transformation. Leuk. Res. 1984;8:737–739
  6. Neame PB, Soamboonsrup P, Benger A, Brain MC. T cell surface antigens in blast crisis of CML. Blood. 1984;63:970–971
  7. Taniguchi C, Yamaguchi K, Yoshioka R, Takifuji N, Matsui K, Nishimura H, et al.  Blast crisis of chronic myelogenous leukemia with tumor formation characterized by T-cell features: a case report. Jpn. J. Clin. Oncol. 1984;14:123–127
  8. Allouche M, Bourinbaiar A, Georgoulias V, Consolini R, Salvatore A, Auclair H, et al.  T cell lineage involvement in lymphoid blast crisis of chronic myeloid leukemia. Blood. 1985;66:1155–1161
  9. Cervantes F, Anegon I, Rozman C, Gallart T, Pereira A, Vives-Corrons JL, et al.  Early T-cell features in blast crisis of Ph1-positive chronic myelogenous leukaemia. Scand. J. Haematol. 1985;35:71–76
  10. Ohyashiki K, Oshimura M, Uchida H, Shirota T, Sakai N, Hirame N, et al.  Characterization of extramedullary tumors in a case of Ph1-positive chronic myelogenous leukemia: possible involvement of immature T lymphocytes. Cancer. Genet. Cytogenet. 1985;15:119–127
  11. Chan LC, Furley AJ, Ford AM, Yardumian DA, Greaves MF. Clonal rearrangement and expression of the T cell receptor b gene and involvement of the breakpoint cluster region in blast crisis of CGL. Blood. 1986;67:533–536
  12. Falini B, Tabilio A, Pelicci PG, Dalla Favera R, Donti E, Rambotti P, et al.  T-cell receptor β-chain gene rearrangement in a case of Ph1-positive chronic myelogenous leukaemia blast crisis. Br. J. Haematol. 1986;62:776–779
  13. Gramatzki M, Bartram CR, Mueller D, Walter M, Tittelbach H, Kalden JR. Early T cell differentiated chronic myeloid leukemia blast crisis with rearrangement of the breakpoint cluster region but not of the T cell receptor β chain genes. Blood. 1987;69:1082–1086
  14. Yasukawa M, Iwamasa K, Kawamura S, Murakami S, Takada K, Hato T, et al.  Phenotypic and genotypic analysis of chronic myelogenous leukaemia with T lymphoblastic and megakaryoblastic mixed crisis. Br. J. Haematol. 1987;66:331–336
  15. Fermand JP, Sigaux F, Tsapis A, Mathieu-Mahul D, Schmitt C, Daniel MT, et al.  T cell-derived blast crisis in chronic myelogenous leukemia. Leukemia. 1987;1:210–212
  16. Kuriyama K, Gale RP, Tomonaga M, Ikeda S, Yao E, Klisak I, et al.  CML-T1: a cell line derived from T-lymphocyte acute phase of chronic myelogenous leukemia. Blood. 1989;74:1381–1387
  17. Advani SF, Malhotra H, Kadam PR, Iyer RS, Nanjangud G, Balsara B, et al.  T-lymphoid blast crisis in chronic myeloid leukemia. Am. J. Hematol. 1991;36:86–92
  18. Sun T, Susin M, Koduru P, Coffey EL, Dittmar K, Weiss R, et al.  Extramedullary blast crisis in chronic myelogenous leukemia: demonstration of T-cell lineage and Philadelphia chromosome in a paraspinal tumor. Cancer. 1991;68:605–610
  19. Smith MR, Mohamed AN, Karanes C. CD7+ TdT+ chronic myelogeneous leukemia blast crisis with null genotype. Leukemia. 1993;7:177–180
  20. Akashi K, Mizuno S, Harada M, Kimura N, Kinjyo M, Shibuya T, et al.  T lymphoid/myeloid bilineal crisis in chronic myelogenous leukemia. Exp. Hematol. 1993;21:743–748
  21. Matsushita K, Arima N, Fukumori J, Daitoku Y, Hidaka S, Ohtsubo H, et al.  Ph1 positive myeloblastic crisis followed by Ph1 negative, bcr rearrangement positive T lymphoid crisis in a CML. Jpn. J. Clin. Hematol. 1993;34:348–354
  22. Konaka Y, Namiuchi S. Extramedullary blast crisis of mixed precursor T lymphoblastic and myeloblastic features in a patient with chronic myelogenous leukemia successfully treated with low dose oral etoposide. Jpn. J. Clin. Hematol. 1993;34:1556–1561
  23. Van Dorpe J, Van Damme S, Jacobs V, Van Den Berghe H, Criel A, Michielssen P, et al.  T-lymphoid extramedullary (lymphadenopathic) blast crisis in CML. Acta. Clinica. Belgica. 1995;50:121–125
  24. Watanabe T, Kataoka T, Mizuta S, Kobayashi M, Uchida T, Imai K, et al.  Establishment and characterization of a novel cell line, TK-6, derived from T cell blast crisis of chronic myelogenous leukemia, with the secretion of parathyroid hormone-related protein. Leukemia. 1995;9:1926–1934
  25. Dorfman DM, Longtine JA, Fox EA, Weinberg DS, Pinkus GS. T-cell blast crisis in chronic myelogenous leukemia: immunophenotypic and molecular biologic findings. Hematopathology. 1997;107:168–176
  26. Kell J, Booth M, Jones B, Appleton M, Lim S. Extramedullary T lymphoblastic transformation of chronic myeloid leukaemia occuring after double allogeneic transplantation. Bone Marrow Transplantation. 1998;22:813–816
  27. Hossain D, Weisberger J, Speekantaiah C, Seiter K. Biphenotypic (Mixed myeloid/T-cell) extramedullary myeloid cell tumor. Leukemia Lymphoma. 1999;33:399–402
  28. Aguayo A, Cortes JE, Kantarjian HM, Beran M, Gandhi V, Plunkett W, et al.  Complete hematologic and cytogenetic response to 2-amino-9-b-D-arabinosyl-6-methoxy-9H-guanine in a patient with chronic myelogeneous leukemia in T-cell blastic phase. Cancer. 1999;85:58–64
  29. Gouttefangeas C, Bensuran A, Boumsell L. Study of the CD-3 associated T-cell receptors reveals further differences between T-cell acute lymphoblastic lymphoma and leukemia. Blood. 1990;75:931–934

PII: S0145-2126(01)00078-9

Leukemia Research
Volume 25, Issue 12 , Pages 1089-1094 , December 2001

Article Tools

* Image Usage & Resolution