Leukemia Research
Volume 25, Issue 12 , Pages 1033-1045 , December 2001

Detailed clonality analysis of relapsing precursor B acute lymphoblastic leukemia: implications for minimal residual disease detection

  • Ai-Hong Li

      Affiliations

    • Department of Medical Biosciences, Pathology, Umeå University, 90187 Umeå, Sweden
  • ,
  • Richard Rosenquist

      Affiliations

    • Department of Medical Biosciences, Pathology, Umeå University, 90187 Umeå, Sweden
  • ,
  • Erik Forestier

      Affiliations

    • Department of Clinical Sciences, Pediatrics, Umeå University, 90187 Umeå, Sweden
  • ,
  • Jack Lindh

      Affiliations

    • Department of Radiation Sciences, Oncology, Umeå University, 90187 Umeå, Sweden
  • ,
  • Göran Roos

      Affiliations

    • Department of Medical Biosciences, Pathology, Umeå University, 90187 Umeå, Sweden
    • Corresponding Author InformationCorresponding author. Tel: +46-90-7851801; fax: +46-90-7852829

Received 16 January 2001 ,Accepted 7 April 2001.

References 

  1. Taylor JJ, Rowe D, Williamson IK, Christmas SE, Proctor SJ, Middleton PG. Detection of T-cell receptor gamma chain V gene rearrangements using the polymerase chain reaction: application to the study of clonal disease cells in acute lymphoblastic leukemia. Blood. 1991;77:1989–1995
  2. Potter MN, Steward CG, Oakhill A. The significance of detection of minimal residual disease in childhood acute lymphoblastic leukaemia. Br. J. Haematol. 1993;83:412–418
  3. Steward CG, Goulden NJ, Katz F, et al.  A polymerase chain reaction study of the stability of Ig heavy-chain and T-cell receptor delta gene rearrangements between presentation and relapse of childhood B-lineage acute lymphoblastic leukemia. Blood. 1994;83:1355–1362
  4. Li AH, Rosenquist R, Forestier E, et al.  Clonal rearrangements in childhood and adult precursor B acute lymphoblastic leukemia: a comparative polymerase chain reaction study using multiple sets of primers. Eur. J. Haematol. 1999;63:211–218
  5. Campana D, Pui CH. Detection of minimal residual disease in acute leukemia: methodologic advances and clinical significance. Blood. 1995;85:1416–1434 (see comments)
  6. Campana D, Coustan-Smith E. Detection of minimal residual disease in acute leukemia by flow cytometry. Cytometry. 1999;38:139–152
  7. van Dongen JJ, Szczepanski T, de Bruijn MA, et al.  Detection of minimal residual disease in acute leukemia patients. Cytokines Mol. Ther. 1996;2:121–133
  8. van Dongen JJ, Seriu T, Panzer-Grumayer ER, et al.  Prognostic value of minimal residual disease in acute lymphoblastic leukaemia in childhood. Lancet. 1998;352:1731–1738 (see comments)
  9. van Dongen JJ, Macintyre EA, Gabert JA, et al.  Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukemia. Leukemia. 1999;13:1901–1928
  10. Cave H, van der Werff ten Bosch J, Suciu S, et al.  Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia. European Organization for Research and Treatment of Cancer — Childhood Leukemia Cooperative Group. New Engl. J. Med. 1998;339:591–598 (see comments)
  11. Roberts WM, Zipf TF, Kitchingman GR, Tubergen DG, Estrov Z. Monitoring residual disease in acute lymphoblastic leukemia: therapeutic implications. Cytokines Mol. Ther. 1995;1:65–69
  12. Panzer-Grumayer ER, Schneider M, Panzer S, Fasching K, Gadner H. Rapid molecular response during early induction chemotherapy predicts a good outcome in childhood acute lymphoblastic leukemia. Blood. ;95. 2000;95:790–794 (published erratum appeared in Blood May 15;95(10):3010)
  13. Coustan-Smith E, Behm FG, Sanchez J, et al.  Immunological detection of minimal residual disease in children with acute lymphoblastic leukaemia. Lancet. 1998;351:550–554 (see comments)
  14. Cave H, Guidal C, Rohrlich P, et al.  Prospective monitoring and quantitation of residual blasts in childhood acute lymphoblastic leukemia by polymerase chain reaction study of delta and gamma T-cell receptor genes. Blood. 1994;83:1892–1902
  15. Roberts WM, Estrov Z, Kitchingman GR, Zipf TF. Detection of minimal residual disease in all: biology, methods, and applications. Cancer Treat. Res. 1996;84:149–166
  16. Macintyre E, d'Auriol L, Amesland F, et al.  Analysis of junctional diversity in the preferential V delta 1-J delta 1 rearrangement of fresh T-acute lymphoblastic leukemia cells by in vitro gene amplification and direct sequencing. Blood. 1989;74:2053–2061
  17. Macintyre EA, d'Auriol L, Duparc N, Leverger G, Galibert F, Sigaux F. Use of oligonucleotide probes directed against T cell antigen receptor gamma delta variable-(diversity)-joining junctional sequences as a general method for detecting minimal residual disease in acute lymphoblastic leukemias. J. Clin. Invest. 1990;86:2125–2135
  18. Beishuizen A, Verhoeven MA, van Wering ER, Hahlen K, Hooijkaas H, van Dongen JJ. Analysis of Ig and T-cell receptor genes in 40 childhood acute lymphoblastic leukemias at diagnosis and subsequent relapse: implications for the detection of minimal residual disease by polymerase chain reaction analysis. Blood. 1994;83:2238–2247
  19. Marshall GM, Kwan E, Haber M, et al.  Characterization of clonal immunoglobulin heavy chain and T cell receptor gamma gene rearrangements during progression of childhood acute lymphoblastic leukemia. Leukemia. 1995;9:1847–1850
  20. Rosenquist R, Thunberg U, Li AH, et al.  Clonal evolution as judged by immunoglobulin heavy chain gene rearrangements in relapsing precursor-B acute lymphoblastic leukemia. Eur. J. Haematol. 1999;63:171–179
  21. Kitchingman GR. Immunoglobulin heavy chain gene VH–D junctional diversity at diagnosis in patients with acute lymphoblastic leukemia. Blood. 1993;81:775–782
  22. Steenbergen EJ, Verhagen OJ, van Leeuwen EF, von dem Borne AE, van der Schoot CE. Distinct ongoing Ig heavy chain rearrangement processes in childhood B-precursor acute lymphoblastic leukemia. Blood. 1993;82:581–589
  23. Steenbergen EJ, Verhagen OJ, van Leeuwen EF, van den Berg H, von dem Borne AE, van der Schoot CE. Frequent ongoing T-cell receptor rearrangements in childhood B-precursor acute lymphoblastic leukemia: implications for monitoring minimal residual disease. Blood. 1995;86:692–702
  24. Choi Y, Greenberg SJ, Du TL, et al.  Clonal evolution in B-lineage acute lymphoblastic leukemia by contemporaneous VH–VH gene replacements and VH–DJH gene rearrangements. Blood. 1996;87:2506–2512
  25. Davi F, Gocke C, Smith S, Sklar J. Lymphocytic progenitor cell origin and clonal evolution of human B-lineage acute lymphoblastic leukemia. Blood. 1996;88:609–621
  26. Kuppers R, Zhao M, Rajewsky K, Hansmann ML. Detection of clonal B cell populations in paraffin-embedded tissues by polymerase chain reaction. Am. J. Pathol. 1993;143:230–239
  27. Kuppers R, Willenbrock K, Rajewsky K, Hansmann ML. Detection of clonal lambda light chain gene rearrangements in frozen and paraffin-embedded tissues by polymerase chain reaction. Am. J. Pathol. 1995;147:806–814
  28. Wasserman R, Yamada M, Ito Y, et al.  VH gene rearrangement events can modify the immunoglobulin heavy chain during progression of B-lineage acute lymphoblastic leukemia. Blood. 1992;79:223–228 (see comments)
  29. Deane M, Pappas H, Norton JD. Immunoglobulin heavy chain gene fingerprinting reveals widespread oligoclonality in B-lineage acute lymphoblastic leukaemia. Leukemia. 1991;5:832–838
  30. Forestier E, Nordenson I, Lindstrom A, Roos G, Lindh J. Simultaneous immunoglobulin/T-cell receptor gene rearrangements and multiclonality in childhood acute lymphoblastic leukemia. Acta Paediatr. 1994;83:319–326
  31. Kleinfield R, Hardy RR, Tarlinton D, Dangl J, Herzenberg LA, Weigert M. Recombination between an expressed immunoglobulin heavy-chain gene and a germline variable gene segment in a Ly 1+ B-cell lymphoma. Nature. 1986;322:843–846
  32. Reth M, Gehrmann P, Petrac E, Wiese P. A novel VH to VHDJH joining mechanism in heavy-chain-negative (null) pre-B cells results in heavy-chain production. Nature. 1986;322:840–842
  33. Vora A, Frost L, Goodeve A, et al.  Late relapsing childhood lymphoblastic leukemia. Blood. 1998;92:2334–2337
  34. Lo Nigro L, Cazzaniga G, Di Cataldo A, et al.  Clonal stability in children with acute lymphoblastic leukemia (ALL) who relapsed five or more years after diagnosis. Leukemia. 1999;13:190–195
  35. Stolz F, Panzer S, Fischer S, Panzer-Grumayer ER. Oligoclonal immunoglobulin heavy-chain and T-cell receptor delta rearrangements persist in a recurrent acute lymphoblastic leukemia with one immunoglobulin kappa rearrangement as a clonal marker. Mod. Pathol. 1999;12:819–826
  36. Kubagawa H, Cooper MD, Carroll AJ, Burrows PD. Light-chain gene expression before heavy-chain gene rearrangement in pre-B cells transformed by Epstein-Barr virus. Proc. Natl. Acad. Sci. USA. 1989;86:2356–2360
  37. Beishuizen A, Hahlen K, Hagemeijer A, et al.  Multiple rearranged immunoglobulin genes in childhood acute lymphoblastic leukemia of precursor B-cell origin. Leukemia. 1991;5:657–667
  38. Green E, McConville CM, Powell JE, et al.  Clonal diversity of Ig and T-cell-receptor gene rearrangements identifies a subset of childhood B-precursor acute lymphoblastic leukemia with increased risk of relapse. Blood. 1998;92:952–958

PII: S0145-2126(01)00072-8

Leukemia Research
Volume 25, Issue 12 , Pages 1033-1045 , December 2001