Leukemia Research
Volume 25, Issue 9 , Pages 821-825 , 1 September 2001

Inhibition of protein kinase C δ has negative effect on anchorage-independent growth of BCR-ABL-transformed Rat1 cells

Received 17 October 2000 ,Accepted 21 January 2001.

References 

  1. Maru Y, Witte ON. How does the chimeric BCR-ABL oncogene function in chronic myelogenous leukemia?. In:  Thomas DE editors. Application of Basic Science to Hematopoiesis and Treatment of Disease. New York: Raven Press; 1993;p. 123–143
  2. Sun X, Wu F, Datta R, Kharbanda S, Kufe D. Interaction between protein kinase C-delta and the c-Abl tyrosine kinase in the cellular response to oxidative stress. J. Biol. Chem. 2000;275:7470–7473
  3. Yuan ZM, Shioya H, Ishiko T, Sun X, Gu J, Huang Y, et al. p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage. Nature. 1999;399:814–817
  4. Baskaran R, Wood LD, Whitaker LL, Canman CE, Morgan SE, Xu Y, et al. Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation. Nature. 1997;387:516–519
  5. Yuan ZM, Utsugisawa T, Ishiko T, Nakada S, Huang Y, Kharbanda S, et al. Activation of protein kinase C-delta by the c-Abl tyrosine kinase in response to ionizing radiation. Oncogene. 1998;16:1643–1648
  6. Bharti A, Kraeft SK, Gounder M, Pandey P, Jin S, Yuan ZM, et al. Inactivation of DNA-dependent protein kinase by protein kinase C-delta: implications for apoptosis. Mol. Cell. Biol. 1998;18:6719–6728
  7. Pendergast AM, Traugh JA, Witte ON. Normal cellular and transformation-associated abl protein share common sites for protein kinase C phosphorylation. Mol. Cell. Biol. 1987;7:4280–4289
  8. Nishizuka Y. Protein kinase C and lipid signaling for sustained cellular responses. FASEB J. (Review). 1995;9:484–496
  9. Mizuno K, Kubo K, Saido T, Akita Y, Osada S, Kuroki T, et al. Structure and properties of a ubiquitously expressed protein kinase c, nPKC-delta. Eur. J. Biochem. 1991;202:931–940
  10. Lu Z, Hornia A, Jiang Y, Zang Q, Ohno S, Foster DA. Tumor promotion by depleting cells of protein kinase C-delta. Mol. Cell. Biol. 1997;17:3418–3428
  11. Goga A, McLaughlin J, Afar DEH, Saffran DC, Witte ON. Alternative signals to Ras for hematopoietic transformation by the BCR-ABL oncogene. Cell. 1995;82:981–988
  12. Sawyers CL, Callahan W, Witte ON. Dominant negative MYC blocks transformation by ABL oncogene. Cell. 1992;70:901–910
  13. Skorski T, Bellacosa A, Nieborowska-Skorska M, Majewski M, Martinez R, Choi JK, et al. Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway. EMBO J. 1997;16:6151–6161
  14. Jamienson L, Carpenter L, Binden TJ, Fields AP. Protein kinase C-iota activity is necessary for Bcr-Abl-mediated resistance to drug-induced apoptosis. J. Biol. Chem. 1999;274:3927–3930
  15. Maru Y, Afar DE, Witte ON, Shibuya M. The dimerization property of glutathione S-transferase partially reactivates BCR-ABL lacking the oligomerization domain. J. Biol. Chem. 1996;271:15353–15357
  16. Maru Y, Yamaguchi S, Takahashi T, Ueno H, Shibuya M. Virally activated Ras cooperates with integrin to induce tubulogenesis in sinusoidal endothelial cell lines. J. Cell. Physiol. 1998;176:223–234
  17. Matiny-Barton G, Kazanietz MG, Mischak H, Blumberg PM, Kochs G, Hug H, et al. Selective inhibition of protein kinase C isozymes by the indolocarbazole Go6976. J. Biol. Chem. 1993;268:9194–9197
  18. Qatsha KA, Rudolph C, Marme D, Schachtele C, May WS. Go6976, a selective inhibitor of protein kinase C, is a potent antagonist of human immunodeficiency virus 1 induction from latent/low-level-producing reservoir cells in vitro. Proc. Natl. Acad. USA. 1993;90:4674–4678
  19. Toullec D, Pianetti P, Coste H, Bellevergue P, Grand-Perret T, Ajakane M, et al. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J. Biol. Chem. 1991;266:15771–15781
  20. Gschwendt M, Muller HJ, Kielbassa K, Zang R, Kittstein W, Rincke G, et al. Rottlerin, a novel protein kinase inhibitor. Biochem. Biophys. Res. Commun. 1994;199:93–98
  21. Acs P, Wang QJ, Bogi K, Marquez AM, Lorenzo PS, Biro T, et al. Both the catalytic and regulatory domains of protein kinase C chimeras modulate the proliferative properties of NIH3T3 cells. J. Biol. Chem. 1997;272:28793–228799
  22. Kiley SC, Clark KJ, Duddy SK, Welch DR, Jaken S. Increased protein kinase C delta in mammary tumor cells: relationship to transformation and metastatic progression. Oncogene. 1999;18:6748–6757
  23. Liao L, Ramsay K, Jaken S. Protein kinase C isozymes in progressively transformed rat embryo fibroblasts. Cell. Growth Differ. 1994;5:1185–1194
  24. Gschwendt M, Kittstein W, Marks F. Elongation factor-2 kinase: effective inhibition by the novel protein kinase inhibitor rottlerin and relative insensitivity towards staurosporine. FEBS lett. 1994;338:855–888
  25. Denning MF, Dlugosz AA, Threadgill DW, Magnuson T, Yuspa SH. Activation of the epidermal growth factor receptor signal transduction pathway stimulates tyrosine phosphorylation of protein kinase C delta. J. Biol. Chem. 1996;271:5325–5331
  26. Downward J. Lipid-regulated kinases: some common themes at last. Science. 1998;279:673–674
  27. Good JA, Zeigler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science. 1998;281:2042–2045
  28. Popoff IJ, Deans JP. Activation and tyrosine phosphorylation of protein kinase C delta in response to B cell antigen receptor stimulation. Mol. Immunol. 1999;36:1005–1016
  29. Irani K, Xia Y, zweier JL, Sollott SJ, Der CJ, Fearon ER, et al. Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts. Science. 1997;275:1649–1652
  30. Skorski T, Wlodarski P, Daheron L, Salomoni P, Nieborowska-Skorska M, Majewski M, et al. BCR/ABL-mediated leukemogenesis requires the activity of the small GTP-binding protein Rac. Proc. Natl. Acad. USA. 1998;95:11858–11862

PII: S0145-2126(01)00031-5

Leukemia Research
Volume 25, Issue 9 , Pages 821-825 , 1 September 2001