Leukemia Research
Volume 25, Issue 9 , Pages 749-755 , 1 September 2001

Molecular detection of tumor cells at diagnosis invading the bone marrow and peripheral blood of patients with aggressive or indolent lymphomas

  • Akihiko Yokohama

      Affiliations

    • Third Department of Internal Medicine, Gunma University, School of Medicine, 3-39-15 Showa-cho, Maebashi, Gunma 371-8511, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-27-2208166; fax: +81-27-2208173
  • ,
  • Masamitsu Karasawa

      Affiliations

    • Transfusion service, Gunma University, School of Medicine, 3-39-15 Showa-cho, Maebashi, Gunma 371-8511, Japan
  • ,
  • Hirotaka Sakai

      Affiliations

    • Third Department of Internal Medicine, Gunma University, School of Medicine, 3-39-15 Showa-cho, Maebashi, Gunma 371-8511, Japan
  • ,
  • Kiyoshi Okamoto

      Affiliations

    • Third Department of Internal Medicine, Gunma University, School of Medicine, 3-39-15 Showa-cho, Maebashi, Gunma 371-8511, Japan
  • ,
  • Tadashi Maehara

      Affiliations

    • Third Department of Internal Medicine, Gunma University, School of Medicine, 3-39-15 Showa-cho, Maebashi, Gunma 371-8511, Japan
  • ,
  • Norifumi Tsukamoto

      Affiliations

    • Third Department of Internal Medicine, Gunma University, School of Medicine, 3-39-15 Showa-cho, Maebashi, Gunma 371-8511, Japan
  • ,
  • Junichi Tamura

      Affiliations

    • Third Department of Internal Medicine, Gunma University, School of Medicine, 3-39-15 Showa-cho, Maebashi, Gunma 371-8511, Japan
  • ,
  • Takuji Naruse

      Affiliations

    • Third Department of Internal Medicine, Gunma University, School of Medicine, 3-39-15 Showa-cho, Maebashi, Gunma 371-8511, Japan
  • ,
  • Morio Sawamura

      Affiliations

    • National Nishigunma Hospital, Gunma 377-8511, Japan
  • ,
  • Shunichi Shimano

      Affiliations

    • Gunma Cancer Center, Gunma 373-8511, Japan

Received 27 June 2000 ,Accepted 30 December 2000.

References 

  1. Fisher R, Gaynor E, Dahlber S, Oken M, Grogan T, Mize E, et al. Comparison of a standard regimen (CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin's lymphoma. New Engl. J. Med. 1993;328:1002
  2. Hoppe R, Kushlan P, Kaplan H, Rosenberg S, Brown B. The treatment of advanced stage favorable histology non-Hodgkin's lymphoma: a preliminary report of a randomized trial comparing single agent chemotherapy, combination chemotherapy, and whole body irradiation. Blood. 1981;58:592
  3. Portlock C. Management of the low-grade non-Hodgkin's lymphoma. Semin. Oncol. 1990;17:51
  4. Freedman A, Neuberg D, Mauch P, Soiffer R, Anderson K, Fisher D, et al. Long-term follow-up of autologous bone marrow transplantation in patients with relapsed follicular lymphoma. Blood. 1999;94:3325
  5. Paryani S, Hoppe R, Cox R, Colby T, Kaplan H. The role of radiation therapy in the management of stage III follicular lymphoma. J. Clin. Oncol. 1984;2:841
  6. Amiot L, Onno M, Lamy T, Dauriac C, Prise P-YL, Fauchet R, et al. Loss of HLA molecules in B lymphomas is associated with an aggressive clinical course. Br. J. Haematol. 1998;100:655
  7. The International non-Hodgkin's Lymphoma Prognostic Factors Project, A predictive model for aggressive Non-Hodgkin's lymphoma. N Engl J Med 1993;329:987.
  8. Cassuto J, Krebs B, Viot G, Dujardin P, Masseyeff R. Beta-2-microglobulin, a tumor marker of lymphoproliferative disorders. Lancet. 1978;ii:108
  9. Hagberg H, Killander A, Simonsson B. Beta-2-microglobulin in malignant lymphoma. Cancer. 1983;51:2220
  10. Lopez-Guillermo A, Cabanillas F, McDonnel T, McLaughlin P, Smith T, Pugh W, et al. Correlation of bcl-2 rearrangement with clinical characteristics and outcome in indolent follicular lymphoma. Blood. 1999;93:3081
  11. Tonegawa S. Somatic generation of antibody diversity. Nature. 1983;302:575
  12. Yamada M, Hudson S, Tournay O, Bittenbender S, Shane S, Lange B, et al. Detection of minimal disease in hematopoietic malignancies of the B-cell lineage by using complementary determining region III (CDR-III)-specific probes. Proc. Natl. Acad. Sci. USA. 1989;86:5123
  13. Harris N, Jaffe E, Stein H, Banks P, Chan J, Cleary M, et al. A revised European–American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood. 1994;84:1361
  14. Bahler D, Swerdlow S. Clonal salivary gland infiltrates associated with myeloepithelial sialadenitis (Sjogren's Syndrome) benign as nonmalignant antigen-selected expansions. Blood. 1998;91:1864
  15. Zwicky C, Maddochs A, Andersen N, Gribben J. Eradication of polymerase chain reaction-detectable immunoglobulin gene rearrangement in non-Hodgkin's lymphoma associated with decreased relapse after autologous bone marrow transplantation. Blood. 1996;88:3314
  16. Maeda Y, Hopriguchi F, Morita S, Matsuda M, Shirakawa C, Masaki H, et al. Detection of minimal residual disease using clonospecific primers for CDRIII in patients with acute B lymphocytic leukemia with or without the Philadelphia chromosome: possibility of clinical application as a tool for improving prognosis. Exp. Hematol. 1994;22:881
  17. Brisco M, Sykes P, Hughes E, Dolman G, Neoh S-H, Peng L-M, et al. Monitoring minimal residual disease in peripheral blood in B-lineage acute lymphoblastic leukemia. Br. J. Haematol. 1997;99:314
  18. Langlands K, Craig J, Anthony R, Parker C. Clonal selection in acute lymphoblastic leukemia demonstrated by polymerase chain reaction analysis of immunoglobulin heavy chain and T-cell receptor beta chain rearrangements. Leukemia. 1993;7:1066
  19. Kurokawa T, Kitani T, Ito T, Taito H, Hotta T. Detection of minimal residual disease in B-cell lymphoma by a PCR-mediated RNase protection assay. Leukemia. 1996;10:1222
  20. Kurokawa T, Kinoshita T, Murata T, Nagasaka T, Kagami Y, Ogura M, et al. Complementary determining region III is a useful molecular marker for the evaluation of minimal residual disease in mantle cell lymphoma. Br. J. Haematol. 1997;98:408
  21. Coad J, Olson D, Christensen D, Lander T, Chibbar R, McGlennen R, et al. Correlation of PCR-detected clonal gene rearrangements with bone marrow morphology in patients with B-lineage lymphomas. Am. J. Surg. Pathol. 1997;12:1047
  22. Crotty P, Smith B, Tallini G. Morphologic, immunophenotypic, and molecular evaluation of bone marrow involvement in non-Hodgkin's lymphoma. Diagn. Mol. Pathol. 1998;7:90
  23. Linden A, Zankovich R, Theissen P, Diehl V, Schicha H. Malignant lymphoma: bone marrow imaging versus biopsy. Radiology. 1989;173:335
  24. Smith B, Weinberg D, Robert N, Towle M, Luther E, Pinkus G, et al. Circulating monoclonal B lymphocytes in non-Hodgkin's lymphoma. N. Engl. J. Med. 1984;311:1476
  25. Johnson A, Cavallin-Stahl E, Akerman M. Flow cytometric light chain analysis of peripheral blood lymphocytes in patients with non-Hodgkin's lymphoma. Br. J. Cancer. 1985;52:159
  26. Ligler F, Smith R, Kettman J, Hernandez J, Himes J, Vitetta E, et al. Detection of tumor cells in the peripheral blood of nonleukemic patients with B-cell lymphoma: analysis of ‘clonal excess’. Blood. 1980;55:792
  27. Horning S, Galili N, Cleary M, Sklar J. Detection of non-Hodgkin's lymphoma in the peripheral blood by analysis of antigen receptor gene rearrangements: results of a prospective study. Blood. 1990;75:1139
  28. Cleary M, Chao J, Warnke R, Sklar J. Immunoglobulin gene rearrangement as a diagnostic criterion of B-cell lymphoma. Proc. Natl. Acad. Sci. USA. 1984;81:593
  29. Lehman C, Sarago C, Nasim S, Comerford J, Karcher D, Garrett C. Comparison of PCR with Southern hybridization for the routine detection of immunoglobulin heavy chain gene rearrangements. Am. J. Clin. Pathol. 1995;103:171
  30. Beristein N, Reis M, Ngan B, Sawka C, Jamal H, Kuzniar B. Detection of occult lymphoma in the peripheral blood and bone marrow of patients with untreated early-stage and advanced-stage follicular lymphoma. J. Clin. Oncol. 1993;11:1344
  31. Döhner H, Gückel F, Knauf W, Semmler W, van Kaick G, Ho A, et al. Magnetic resonance image of bone marrow in lymphoproliferative disorders: correlation with bone marrow biopsy. Br. J. Haematol. 1989;73:12
  32. Moormeier J, Williams S, Golomb H. The staging of non-Hodgkin's lymphomas. Seminar Oncol. 1990;17:43
  33. Reimer R, Chabner B, Young R, Reddick R, Johnson R. Lymphoma presenting in bone: results of histopathology, staging, and therapy. Ann. Int. Med. 1977;87:50
  34. Hoane B, Shields A, Porter B, Shulman H. Detection of lymphomatous bone marrow involvement with magnetic resonance imaging. Blood. 1991;78:728
  35. Trainor K, Brisco M, Story C, Morley A. Monoclonality in B-lymphoproliferative disorders detected at the DNA level. Blood. 1990;75:2220
  36. Bahler D, Campbell M, Hart S, Miller R, Levy S, Levy R. Immunoglobulin VH gene expression among human follicular lymphoma. Blood. 1991;78:1561
  37. Biladeau D, Blackstadt M, Greipp P, Kyle R, Oken M, Kay N, et al. Analysis of B-lymphoid malignancy using allele-specific polymerase chain reaction: a technique for sequential quantitation of residual disease. Blood. 1991;78:3021
  38. Deane M, Norton N. Detection of immunoglobulin gene rearrangement in B lymphoid malignancies by polymerase chain reaction gene amplification. Br. J. Haematol. 1990;74:251
  39. Veelken H, Tycko B, Sklar J. Sensitive detection of clonal antigen receptor gene rearrangements for the diagnosis and monitoring of lymphoid neoplasms by a polymerase chain reaction-mediated ribonuclease protection assay. Blood. 1991;78:1318
  40. van Belzen N, Hupkes P, Doekharan D, Hoogeveen-Westerveld M, Dorssers L, van't Veer M. Detection of minimal disease using rearranged immunoglobulin heavy chain genes from intermediate- and high-grade malignant B cell non-Hodgkin's lymphoma. Leukemia. 1997;11:1742
  41. Segal G, Jorgensen T, Scott M, Braylan R. Optimal primer selection for clonality assessment by polymerase chain reaction analysis. Hum. Pathol. 1994;25:1276
  42. Chen Y-T, Whitney K, Chen Y. Clonality analysis of B-cell lymphoma in fresh-frozen and paraffin-embedded tissue: the effects of variable polymerase chain reaction parameters. Mod. Pathol. 1994;7:429
  43. Corbally N, Grogan L, Dervan P, Carney D. The detection of specific gene rearrangements in non-Hodgkin's lymphoma using the polymerase chain reaction. Br. J. Cancer. 1992;66:805
  44. Zelenetz A, Chen T, Levy R. Histologic transformation of follicular lymphoma to diffuse lymphoma represents tumor progression by a single malignant B cell. J. Exp. Med. 1991;173:197
  45. Ottensmeier C, Thompsett A, Zhu D, Wilkins B, Sweetenham J, Stevenson F. Analysis of VH gene in follicular and diffuse lymphoma showed ongoing somatic mutation and multiple isotype transcripts in early disease with changes during disease progression. Blood. 1998;91:4292
  46. Chapman C, Mockridge C, Rowe M, Rickinson A, Stevenson F. Analysis of VH genes used by neoplastic B cells in endemic Burkitt's lymphoma shows somatic hypermutation and intraclonal heterogeneity. Blood. 1995;85:2176
  47. Wasserman R, Felix C, McKenzie S, Shane S, Lange B, Finger L. Identification of an altered immunoglobulin heavy-chain gene rearrangement in the central nervous system in B-precursor acute lymphoblastic leukemia. Leukemia. 1993;7:1294
  48. Gribben J, Neuberg D, Freedman A, Gimmi C, Pesek K, Barber M, et al. Detection by polymerase chain reaction of residual cells with the bcl-2 translocation is associated with increased risk of relapse after autologous bone marrow transplantation for B-cell lymphoma. Blood. 1993;89:3449
  49. Bustin S, Gyselman V, Williams N, Dorudi S. Detection of cytokeratins 19/20 and guanylyl cyclase C in peripheral blood of colorectal cancer patients. Br. J. Cancer. 1999;79:1813

PII: S0145-2126(01)00015-7

Leukemia Research
Volume 25, Issue 9 , Pages 749-755 , 1 September 2001