Leukemia Research
Volume 24, Issue 7 , Pages 575-582 , July 2000

Pattern of immunoglobulin (Ig) and T-cell receptor (TCR) gene rearrangements in childhood acute lymphoblastic leukemia in India

  • Sudha Sazawal

      Affiliations

    • Department of Haematology, All India Institute of Medical Sciences, IRCH Building (1st Floor), AIIMS, New Delhi 110029, India
    • ,
  • Kishor Bhatia

      Affiliations

    • Lymphoma Biology Section, Paediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, MA, USA
    • ,
  • Sandeep Gurbuxani

      Affiliations

    • Department of Haematology, All India Institute of Medical Sciences, IRCH Building (1st Floor), AIIMS, New Delhi 110029, India
    • ,
  • Laxman Singh Arya

      Affiliations

    • Department of Paediatrics, All India Institute of Medical Sciences, New Delhi, India
    • ,
  • Vinod Raina

      Affiliations

    • Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India
    • ,
  • Anshu Khattar

      Affiliations

    • Department of Haematology, All India Institute of Medical Sciences, IRCH Building (1st Floor), AIIMS, New Delhi 110029, India
    • ,
  • Tribhawan Vats

      Affiliations

    • Department of Paediatrics, Texas Tech University Health Sciences Centre, Amarillo, TX, USA
    • ,
  • Ian Magrath

      Affiliations

    • Lymphoma Biology Section, Paediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, MA, USA
    • ,
  • Manorama Bhargava

      Affiliations

    • Department of Haematology, All India Institute of Medical Sciences, IRCH Building (1st Floor), AIIMS, New Delhi 110029, India
    • Corresponding Author InformationCorresponding author. Tel.: +91-11-6523147; fax: +91-11-6862663

Received 27 August 1999 ,Accepted 5 February 2000.

References 

  1. Ramot B, Magrath I. Hypothesis: the environment is a major determinant of the immunological subtype of lymphomas and acute lymphoblastic leukaemia in children. Br. J. Haematol. 1982;52:183
  2. O’Conor GT. Geography of lymphoid neoplasia: an overview. In:  Magrath IT,  O’Conor GT,  Ramot B editor. Pathogenesis of Leukemias and Lymphomas: Environmental influences. New York: Raven Press; 1984;p. 1–8
  3. Rajalekshmy KR, Abitha AR, Pramila R, et al.  Immunophenotyping of acute lymphoblastic leukemia in Madras, India. Leuk. Res. 1984;18:183
  4. Bhargava M, Kumar R, Karak A, et al.  Immunological subtypes of acute lymphoblastic leukemia in north India. Leuk. Res. 1988;12:673
  5. Kamat DM, Gopal R, Advani SH, et al.  Pattern of subtypes of acute lymphoblastic leukemia in India. Leuk. Res. 1985;9:927
  6. Advani SH, Rao DN, Gopal R, Nair CN, Bhattacharya M. Acute lymphoblastic leukemia: end result analysis of treatment and prognostic factors in Indian patients. Am. J. Hematol. 1993;15:35
  7. Greaves MF. Stem cell origin of leukemia and curability. Br. J. Cancer. 1993;6:413
  8. Maniatis T, Fritsch EF, Sambrook J. Molecular Cloning: A Laboratory Manual. 2nd ed.. New York: Cold Spring Harbor Laboratory Press; 1989;
  9. Southern EM. Detection of specific sequences among DNA fragments seperated by gel electrophoresis. J. Mol. Biol. 1975;98:503
  10. Felix CA, Poplack DG, Reaman GH, et al.  Characterization of immunoglobulin and T-cell receptor gene patterns in B cell precursor acute lymphoblastic leukemia of childhood. J. Clin. Oncol. 1990;8:431
  11. Murre C, Waldman RA, Mortan CC, et al.  Human γ-chain genes are rearranged in leukemic T cells and map to the short arm of chromosome 7. Nature. 1985;316:549
  12. Beishuizen A, Hahlen K, Hagemeijer A, et al.  Multiple rearranged immunoglobulin genes in childhood acute lymphoblastic leukemia of precursor B-cell origin. Leukemia. 1991;5:657
  13. Katz F, Ball L, Gibbons B, Chessells J. The use of DNA probes to monitor minimal residual disease in childhood acute lymphoblastic leukaemia. Br. J. Haematol. 1989;73:173
  14. Bird J, Galili N, Link M, Stites D, Sklar J. Continuing rearrangement but absence of somatic hypermutation in immunoglobulin genes of human B cell precursor leukemia. J. Exp. Med. 1988;168:229
  15. Kitchingman GR, Mirro J, Stass S, et al.  Biologic and prognostic significance of the presence of more than two μ heavy-chain genes in childhood acute lymphoblastic leukemia of B precursor cell origin. Blood. 1986;67:698
  16. Kitchingman GR. Immunoglobulin heavy chain gene VĤ-D junctional diversity at diagnosis in patients with acute lymphoblastic leukemia. Blood. 1993;81:775
  17. Steenbergen EJ, Verhagen OJHM, Van Leeuwen EF, Von dem Borne AGG, Van der Schoot CE. Distinct ongoing Ig heavy chain rearrangement processes in childhood B-precursor acute lymphoblastic leukemia. Blood. 1993;82:581
  18. Wasserman R, Yamada M, Ito Y, et al.  VĤ gene rearrangement events can modify the immunoglobulin heavy chain during progression of B-lineage acute lymphoblastic leukemia. Blood. 1992;79:223
  19. Kleinfield R, Hardy RR, Tarlinton D, et al.  Recombination between an expressed immunoglobulin heavy-chain gene and a germline variable gene segment in a Ly 1+B-cell lymphoma. Nature. 1986;322:843
  20. Reth M, Gehrmann P, Petrac E, Wiese P. A novel VĤ to VĤDJĤ joining mechanism in heavy-chain-negative (null) pre-B cells results in heavy-chain production. Nature. 1986;322:840
  21. Reth MG, Jackson S, Alt FW. VĤDJĤ formation and DJĤ replacement during pre-B differentiation: non-random usage of gene segments. EMBO J. 1986;5:2131
  22. Aisenberg AC, Wilkes BM, Jacobson JO. Different T-cell receptor gene configurations in T-cell neoplasms and acute lymphoblastic leukemia. Cancer Res. 1991;51:6103
  23. Tawa A, Benedict SH, Hara J, Hozumi N, Gelfand EW. Rearrangement of the T-cell receptor γ-chain gene in childhood acute lymphoblastic leukemia. Blood. 1987;70:1933
  24. Hamdy N, Bhatia K, Shaker H, et al.  Molecular epidemiology of acute lymphoblastic leukemia in Egypt. Leukemia. 1995;9:194
  25. Felix CA, Wright JJ, Poplack DG, et al.  T cell receptor α-,β- & γ-genes in T cell and Pre-B cell acute lymphoblastic leukemia. J. Clin. Invest. 1987;80:545
  26. Hara J, Benedict SH, Champagne E, et al.  T cell receptor δ gene rearrangements in acute lymphoblastic leukemia. J. Clin. Invest. 1988;82:1974
  27. Shanta V, Maitreyan V, Sagar TG, Gajalakshmi CK, Rajalekshmi KR. Prognostic variables and survival in pediatric acute lymphoblastic leukemias: Cancer Institute Experience. Pediatr. Hematol. Oncol. 1996;13:205
  28. Advani S, Pai S, Venzon D, et al.  Acute lymphoblastic leukemia in India: an analysis of prognostic factors using a single treatment regimen. Ann. Oncol. 1999;10:167

PII: S0145-2126(00)00025-4

Leukemia Research
Volume 24, Issue 7 , Pages 575-582 , July 2000

Article Tools

* Image Usage & Resolution