Expression and prognostic significance of the apoptotic genes BCL2L13, Livin, and CASP8AP2 in childhood acute lymphoblastic leukemia

Yang, Yung-Li; Lin, Shu-Rung; Chen, Jiann-Shiuh; Lin, Shu-Wha; Yu, Sung-Liang; Chen, Hsuan-Yu; Yen, Ching-Tzu; Lin, Chien-Yu; Lin, Jing-Fang; Lin, Kai-Hsin; Jou, Shiann-Tarng; Hu, Chung-Yi; Chang, Sheng-Kai; Lu, Meng-Yao; Chang, Hsiu-Hao; Chang, Wan-Hui; Lin, Kuo-Sin; Lin, Dong-Tsamn

doi:10.1016/j.leukres.2009.07.023

« Previous Next »Leukemia Research
Volume 34, Issue 1 , Pages 18-23, January 2010

Expression and prognostic significance of the apoptotic genes BCL2L13, Livin, and CASP8AP2 in childhood acute lymphoblastic leukemia

Yung-Li Yang
- Department of Laboratory Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
- Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan
Shu-Rung Lin
- Department of Bioscience Technology, College of Science, Chung-Yuan Christian University, Taoyuan, Taiwan
Jiann-Shiuh Chen
- Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
- Department of Pediatrics, National Cheng Kung University Hospital, Tainan, Taiwan
Shu-Wha Lin
- Department of Medical Research, College of Medicine, National Taiwan University, Taipei, Taiwan
- National Taiwan University Hospital, Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan
Sung-Liang Yu
- Department of Laboratory Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
- Department of Medical Research, College of Medicine, National Taiwan University, Taipei, Taiwan
- National Taiwan University Hospital, Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan
- NTU Center for Genomic Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
Hsuan-Yu Chen
- Institute of Statistical Science Academia Sinica, Taiwan
Ching-Tzu Yen
- National Taiwan University Hospital, Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan
Chien-Yu Lin
- Institute of Statistical Science Academia Sinica, Taiwan
Jing-Fang Lin
- National Taiwan University Hospital, Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan
Kai-Hsin Lin
- Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan
Shiann-Tarng Jou
- Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan
Chung-Yi Hu
- National Taiwan University Hospital, Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan
Sheng-Kai Chang
- National Taiwan University Hospital, Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan
Meng-Yao Lu
- Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan
Hsiu-Hao Chang
- Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan
Wan-Hui Chang
- Taiwan Childhood Cancer Foundation, Taipei, Taiwan
Kuo-Sin Lin
- Taiwan Childhood Cancer Foundation, Taipei, Taiwan
Dong-Tsamn Lin
- Department of Laboratory Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
- Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan
- Corresponding author at: Department of Laboratory Medicine and Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, No. 7 Chung-San S. Rd., Sec. 1, Taipei 100, Taiwan. Tel.: +886 2 23123456x65399; fax: +886 2 23224263.

Received 15 January 2009; received in revised form 12 July 2009; accepted 14 July 2009.

Abstract

Improved treatment of childhood acute lymphoblastic leukemia (ALL) depends on the identification of new molecular markers that are able to predict treatment response and clinical outcome. The development of impaired apoptosis in leukemic cells is one factor that may influence their response to treatment. We investigated the expression of three apoptosis related genes, BCL2L13, CASP8AP2, and Livin, as well as their prognostic significance, in a retrospective study of 90 pediatric ALL patients diagnosed between 1996 and 2007 in Taiwan. Univariant analysis revealed that high expression of BCL2L13 was associated with inferior event-free survival and overall survival (p<0.001 and 0.005, respectively). Multivariate analysis for EFS and OS demonstrated that high expression of BCL2L13 was an independent prognostic factor for childhood ALL in this ethnic group.