Current Issue June 2012, Vol. 36, No. 6

Issue Highlights

Review Article

Evolution of clinical trial endpoints in chronic myeloid leukemia: Efficacious therapies require sensitive monitoring techniques
June 2012(Vol. 36 | No. 6 | Pages 664-671)
Raoul Tibes, Ruben A. Mesa

Commissioned Editorial Debate

“Should all eligible patients with multiple myeloma receive autologous stem-cell transplant as part of initial treatment?”
June 2012(Vol. 36 | No. 6 | Pages 677-681)
Philippe Moreau, S. Vincent Rajkumar
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Comments on Published Paper

Combination of azacitidine and ESA in myelodysplastic patients: The need for prospective studies
June 2012(Vol. 36 | No. 6 | Pages 682-683)
Massimo Breccia, Giuseppina Loglisci, Adriano Salaroli, Alessandra Serrao, Luigi Petrucci, Irene Zacheo, Giuliana Alimena
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ALK-positive anaplastic large cell lymphoma with TPM3-ALK translocation
16 May 2012
Saeam Shin, Juwon Kim, Sun Och Yoon, Yu Ri Kim, Kyung-A. Lee
Anaplastic large cell lymphoma (ALCL) is a T cell lymphoma consisting of large cells that express CD30 . Anaplastic lymphoma kinase (ALK) is expressed in 50–80% of ALCLs, with a higher frequency of AL...
Casitas B-cell lymphoma mutation in childhood T-cell acute lymphoblastic leukemia
16 May 2012
Yuka Saito, Yoko Aoki, Hideki Muramatsu, Hideki Makishima, Jaroslaw P. Maciejewski, Masue Imaizumi, Takeshi Rikiishi, Yoji Sasahara, Shigeo Kure, Tetsuya Niihori, Shigeru Tsuchiya, Seiji Kojima, Yoichi Matsubara
Abstract: Somatic CBL mutations have been reported in a variety of myeloid neoplasms but are rare in acute lymphoblastic leukemia (ALL). We analyzed 77 samples from hematologic malignancies, identifyi...
Src, Akt, NF-κB, BCL-2 and c-IAP1 may be involved in an anti-apoptotic effect in patients with BCR-ABL positive and BCR-ABL negative acute lymphoblastic leukemia
16 May 2012
José E. Vázquez-Franco, Elba Reyes-Maldonado, Jorge Vela-Ojeda, Maria L. Domínguez-López, Ruth A. Lezama
Abstract: BCR-ABL kinase has been observed to be potentially related to leukemic cell development. Adult patients with acute lymphoblastic leukemia (ALL) were evaluated to determine whether presence/a...
A novel prognosis of acute myeloid leukemia: AML-M2 complicate with thrombocythemia after complete remission
14 May 2012
Yi-xin Chen, Ying Li, Ling-yan Zhang, Bin Liu
In February 2008, a 79-year-old man was admitted into the hospital with a 3-month history of smothered cough and fatigue. The patient had obvious tender pain in the middle and lower sternum and crude ...
A patient with acute megakaryoblastic leukaemia who achieved CRi after decitabine treatment
14 May 2012
Cong Lu, Guangsheng He, Song Jin, Xuhui Zhang, Xiaohui Hu, Depei Wu, Aining Sun, Changgeng Ruan
Acute megakaryoblastic leukaemia (AML-M7) is a rare subtype of acute myeloid leukaemia (<5%), which was first described in 1931 by Von Boros and Koreny . It can occur in both adults and children. A...

View More Articles in Press...

Update on developments in the diagnosis and prognostic evaluation of patients with myelodysplastic syndromes (MDS): Consensus statements and report from an expert workshop
March 2012 (Vol. 36 | No. 3 | Pages 264-270)
Uwe Platzbecker, Valeria Santini, Ghulam J. Mufti, Claudia Haferlach, Jaroslaw P. Maciejewski, Sophie Park, Francesc Solé, Arjan A. van de Loosdrecht, Detlef Haase
The degree of neutropenia has a prognostic impact in low risk myelodysplastic syndrome
March 2012 (Vol. 36 | No. 3 | Pages 287-292)
I. Cordoba, J.R. Gonzalez-Porras, E. Such, B. Nomdedeu, E. Luño, R. de Paz, F. Carbonell, T. Vallespi, M. Ardanaz, F. Ramos, V. Marco, S. Bonanad, M. Sanchez-Barba, D. Costa, T. Bernal, G.F. Sanz, M.C. Cañizo
Clomiphene as a novel modality for the treatment of acute myeloid leukemia: A pilot phase II study
January 2012 (Vol. 36 | No. 1 | Pages 42-45)
G. Yom-Tov, I. Nathan, O. Shpilberg, A. Polliack, I. Levi
The discovery and early understanding of leukemia
January 2012 (Vol. 36 | No. 1 | Pages 6-13)
Kim R. Kampen
Blastic plasmacytoid dendritic cell neoplasm with leukemic presentation, lacking cutaneous involvement: Case series and literature review
January 2012 (Vol. 36 | No. 1 | Pages 81-86)
Michael J. Rauh, Fazlur Rahman, David Good, Jeffrey Silverman, Michael K. Brennan, Nikolay Dimov, Jane Liesveld, Daniel H. Ryan, W. Richard Burack, John M. Bennett

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Publishing Information

Leukemia Research is published by Elsevier.

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About Leukemia Research

Leukemia Research an international journal which brings comprehensive and current information to all health care professionals involved in basic and (or) applied clinical research in leukemias, lymphomas, multiple myeloma and other hematologic malignancies. The editors encourage the submission of articles relevant to normal and leukemic hemopoiesis, biochemistry, cell biology, immunology and molecular biology as well as epidemiologic and clinical studies.

Specifically, of major interest will be articles that encompass the application of oncogenes, growth factors, cell markers, cell cycle and differentiation agents, novel therapeutics and clinical trials in both the acute and chronic leukemias as well as the myelodysplastic syndromes. In addition we solicit selected articles on the rapidly increasing specialty of marrow or stem cell reconstitution after high dose therapy with curative attempt in patients with a wide range of neoplasms.

MDS Foundation Information

The MDS Foundation is a multidisciplinary, international organization devoted to the prevention, treatment, and study of the myelodysplastic syndromes. The organization is based upon the premise that international cooperation will accelerate the process leading to the control and cure of these diseases.